Cancer risks of hematopoietic/lymphatic and urinary system in pharmaceutical plant workers: a systematic review and meta-analysis
Saved in:
| Title: | Cancer risks of hematopoietic/lymphatic and urinary system in pharmaceutical plant workers: a systematic review and meta-analysis |
|---|---|
| Authors: | Jinyoung Moon, Yongseok Mun |
| Source: | BMC Public Health, Vol 25, Iss 1, Pp 1-15 (2025) |
| Publisher Information: | BMC, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Public aspects of medicine |
| Subject Terms: | Pharmaceutical plant workers, Cancer incidence, Cancer mortality, Hematopoietic system, Lymphatic system, Urinary system, Public aspects of medicine, RA1-1270 |
| Description: | Abstract Introduction In this study, we will investigate the risk of hematopoietic/lymphatic system and urinary system cancers in pharmaceutical plant workers. Methods Six pre-defined inclusion criteria were applied. The quality of all included studies was assessed based on the National Toxicology Program Office of Health Assessment and Translation Risk of Bias tool. Conventional meta-analysis was conducted for hematopoietic/lymphatic system and urinary system cancers. Between-study heterogeneity and publication bias were investigated. Results In this systematic review and meta-analysis, four cohort studies of a single pharmaceutical plant, one case-control study, and one cohort study with a nested case-control study were included. For publication bias, the p-value for Egger’s regression test was 0.51 and 0.38 for hematopoietic/lymphatic and urinary system cancer, respectively. Pharmaceutical plant workers showed a 3.19 (95% confidence interval, CI 1.53–6.64) times higher risk of hematopoietic/lymphatic system cancers than the general population. They also showed a 4.86 (95% CI 1.71–13.80) times higher risk of urinary system cancers compared to the general population. Higgins’ I-squared value for between-study heterogeneity was 61.77% (95% CI 0.00–99.06%) and 58.00% (95% CI 0.00–98.67%), respectively. Conclusion From this systematic review and meta-analysis, the authors concluded that potential hazardous occupational exposures of workers in pharmaceutical plants could pose an increased risk of hematopoietic/lymphatic system and urinary system cancer. Future studies should be conducted with a more thorough dose-response relationship distinction. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1471-2458 |
| Relation: | https://doaj.org/toc/1471-2458 |
| DOI: | 10.1186/s12889-025-24408-2 |
| Access URL: | https://doaj.org/article/aad0c69b607a47b2bb12efe4b68aecd6 |
| Accession Number: | edsdoj.0c69b607a47b2bb12efe4b68aecd6 |
| Database: | Directory of Open Access Journals |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science Be the first to leave a comment!