View in EDS

Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study

Saved in:
Bibliographic Details
Title: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study
Contributors: Jung Min Moon, Hyun Jung Lee, Kyungdo Han, Da Hye Kim, Seung Wook Hong, Hosim Soh, Seona Park, Eun Ae Kang, Jooyoung Lee, Seong-Joon Koh, Jong Pil Im, Joo Sung Kim, Kang, Eun Ae
Publisher Information: Wiley-Blackwell
Publication Year: 2021
Subject Terms: Cause of Death, Colorectal Neoplasms* / diagnosis, Colorectal Neoplasms* / epidemiology, Correlation of Data, Early Detection of Cancer* / methods, Early Detection of Cancer* / statistics & numerical data, Female, Humans, Immunochemistry, Ischemic Stroke* / diagnosis, Ischemic Stroke* / epidemiology, Male, Middle Aged, Myocardial Infarction* / diagnosis, Myocardial Infarction* / epidemiology, Occult Blood, Population Surveillance / methods, Predictive Value of Tests, Republic of Korea / epidemiology, cardiovascular diseases, cohort, fecal immunochemical test, myocardial infarction, stroke
Description: Background Although occult hemoglobin in feces is universally valued as a screening tool for colorectal cancer (CRC), only few studies investigated the clinical meaning of fecal immunochemical test (FIT) in other diseases. We evaluated the clinical utility of FIT in patients with cardiovascular diseases (namely, ischemic stroke and myocardial infarction [MI]). Methods and Results Using the National Health Insurance database, participants (aged >50 years) with CRC screening records from 2009 to 2012 were screened and followed up. Subjects with a history of cardiovascular diseases and CRC were excluded. Ischemic stroke, MI, and other comorbidities were defined by International Classification of Diseases, Tenth Revision (ICD-10), codes. Age, sex, smoking, alcohol consumption, regular exercise, diabetes mellitus, hypertension, dyslipidemia, and body mass index were adjusted in a multivariate analysis. A total of 6 277 446 subjects were eligible for analysis. During the mean 6.79 years of follow-up, 168 570 participants developed ischemic stroke, 105 983 developed MI, and 11 253 deaths were observed. A multivariate-adjusted model revealed that the risk of ischemic stroke was higher in the FIT-positive population (adjusted hazard ratio [HR], 1.09; 95% CI, 1.07-1.11). Similarly, FIT-positive subjects were at an increased risk of MI (adjusted HR, 1.09; 95% CI, 1.06-1.12). Moreover, increased all-cause mortality was observed in the FIT-positive population (adjusted HR, 1.15; 95% CI, 1.07-1.23). The increased risk remained consistent in the stratified analysis on anemia and CRC status. Conclusions Positive FIT findings were associated with ischemic stroke, MI, and mortality. Occult blood in feces may offer more clinical information than its well-known conventional role in CRC screening. ; open
Document Type: article in journal/newspaper
Language: English
ISSN: 33372535
Relation: JOURNAL OF THE AMERICAN HEART ASSOCIATION; J01774; https://ir.ymlib.yonsei.ac.kr/handle/22282913/191066; T9992022472
DOI: 10.1161/JAHA.120.017783
Availability: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191066
https://doi.org/10.1161/JAHA.120.017783
Rights: CC BY-NC-ND 2.0 KR
Accession Number: edsbas.F2002A8F
Database: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191066#
    Name: EDS - BASE (s4221598)
    Category: fullText
    Text: View record from BASE
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Moon%20JM
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsbas
DbLabel: BASE
An: edsbas.F2002A8F
RelevancyScore: 919
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 918.9462890625
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study
– Name: Author
  Label: Contributors
  Group: Au
  Data: Jung Min Moon<br />Hyun Jung Lee<br />Kyungdo Han<br />Da Hye Kim<br />Seung Wook Hong<br />Hosim Soh<br />Seona Park<br />Eun Ae Kang<br />Jooyoung Lee<br />Seong-Joon Koh<br />Jong Pil Im<br />Joo Sung Kim<br />Kang, Eun Ae
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Wiley-Blackwell
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2021
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cause+of+Death%22">Cause of Death</searchLink><br /><searchLink fieldCode="DE" term="%22Colorectal+Neoplasms*+%2F+diagnosis%22">Colorectal Neoplasms* / diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Colorectal+Neoplasms*+%2F+epidemiology%22">Colorectal Neoplasms* / epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Correlation+of+Data%22">Correlation of Data</searchLink><br /><searchLink fieldCode="DE" term="%22Early+Detection+of+Cancer*+%2F+methods%22">Early Detection of Cancer* / methods</searchLink><br /><searchLink fieldCode="DE" term="%22Early+Detection+of+Cancer*+%2F+statistics+%26+numerical+data%22">Early Detection of Cancer* / statistics & numerical data</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Immunochemistry%22">Immunochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+Stroke*+%2F+diagnosis%22">Ischemic Stroke* / diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+Stroke*+%2F+epidemiology%22">Ischemic Stroke* / epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Myocardial+Infarction*+%2F+diagnosis%22">Myocardial Infarction* / diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Myocardial+Infarction*+%2F+epidemiology%22">Myocardial Infarction* / epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Occult+Blood%22">Occult Blood</searchLink><br /><searchLink fieldCode="DE" term="%22Population+Surveillance+%2F+methods%22">Population Surveillance / methods</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+Value+of+Tests%22">Predictive Value of Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Republic+of+Korea+%2F+epidemiology%22">Republic of Korea / epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22cardiovascular+diseases%22">cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22cohort%22">cohort</searchLink><br /><searchLink fieldCode="DE" term="%22fecal+immunochemical+test%22">fecal immunochemical test</searchLink><br /><searchLink fieldCode="DE" term="%22myocardial+infarction%22">myocardial infarction</searchLink><br /><searchLink fieldCode="DE" term="%22stroke%22">stroke</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background Although occult hemoglobin in feces is universally valued as a screening tool for colorectal cancer (CRC), only few studies investigated the clinical meaning of fecal immunochemical test (FIT) in other diseases. We evaluated the clinical utility of FIT in patients with cardiovascular diseases (namely, ischemic stroke and myocardial infarction [MI]). Methods and Results Using the National Health Insurance database, participants (aged >50 years) with CRC screening records from 2009 to 2012 were screened and followed up. Subjects with a history of cardiovascular diseases and CRC were excluded. Ischemic stroke, MI, and other comorbidities were defined by International Classification of Diseases, Tenth Revision (ICD-10), codes. Age, sex, smoking, alcohol consumption, regular exercise, diabetes mellitus, hypertension, dyslipidemia, and body mass index were adjusted in a multivariate analysis. A total of 6 277 446 subjects were eligible for analysis. During the mean 6.79 years of follow-up, 168 570 participants developed ischemic stroke, 105 983 developed MI, and 11 253 deaths were observed. A multivariate-adjusted model revealed that the risk of ischemic stroke was higher in the FIT-positive population (adjusted hazard ratio [HR], 1.09; 95% CI, 1.07-1.11). Similarly, FIT-positive subjects were at an increased risk of MI (adjusted HR, 1.09; 95% CI, 1.06-1.12). Moreover, increased all-cause mortality was observed in the FIT-positive population (adjusted HR, 1.15; 95% CI, 1.07-1.23). The increased risk remained consistent in the stratified analysis on anemia and CRC status. Conclusions Positive FIT findings were associated with ischemic stroke, MI, and mortality. Occult blood in feces may offer more clinical information than its well-known conventional role in CRC screening. ; open
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 33372535
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: JOURNAL OF THE AMERICAN HEART ASSOCIATION; J01774; https://ir.ymlib.yonsei.ac.kr/handle/22282913/191066; T9992022472
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1161/JAHA.120.017783
– Name: URL
  Label: Availability
  Group: URL
  Data: https://ir.ymlib.yonsei.ac.kr/handle/22282913/191066<br />https://doi.org/10.1161/JAHA.120.017783
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: CC BY-NC-ND 2.0 KR
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.F2002A8F
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.F2002A8F
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1161/JAHA.120.017783
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Cause of Death
        Type: general
      – SubjectFull: Colorectal Neoplasms* / diagnosis
        Type: general
      – SubjectFull: Colorectal Neoplasms* / epidemiology
        Type: general
      – SubjectFull: Correlation of Data
        Type: general
      – SubjectFull: Early Detection of Cancer* / methods
        Type: general
      – SubjectFull: Early Detection of Cancer* / statistics & numerical data
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Immunochemistry
        Type: general
      – SubjectFull: Ischemic Stroke* / diagnosis
        Type: general
      – SubjectFull: Ischemic Stroke* / epidemiology
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Myocardial Infarction* / diagnosis
        Type: general
      – SubjectFull: Myocardial Infarction* / epidemiology
        Type: general
      – SubjectFull: Occult Blood
        Type: general
      – SubjectFull: Population Surveillance / methods
        Type: general
      – SubjectFull: Predictive Value of Tests
        Type: general
      – SubjectFull: Republic of Korea / epidemiology
        Type: general
      – SubjectFull: cardiovascular diseases
        Type: general
      – SubjectFull: cohort
        Type: general
      – SubjectFull: fecal immunochemical test
        Type: general
      – SubjectFull: myocardial infarction
        Type: general
      – SubjectFull: stroke
        Type: general
    Titles:
      – TitleFull: Occult Blood in Feces Is Associated With an Increased Risk of Ischemic Stroke and Myocardial Infarction: A Nationwide Population Study
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jung Min Moon
      – PersonEntity:
          Name:
            NameFull: Hyun Jung Lee
      – PersonEntity:
          Name:
            NameFull: Kyungdo Han
      – PersonEntity:
          Name:
            NameFull: Da Hye Kim
      – PersonEntity:
          Name:
            NameFull: Seung Wook Hong
      – PersonEntity:
          Name:
            NameFull: Hosim Soh
      – PersonEntity:
          Name:
            NameFull: Seona Park
      – PersonEntity:
          Name:
            NameFull: Eun Ae Kang
      – PersonEntity:
          Name:
            NameFull: Jooyoung Lee
      – PersonEntity:
          Name:
            NameFull: Seong-Joon Koh
      – PersonEntity:
          Name:
            NameFull: Jong Pil Im
      – PersonEntity:
          Name:
            NameFull: Joo Sung Kim
      – PersonEntity:
          Name:
            NameFull: Kang, Eun Ae
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 33372535
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1