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Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study

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Title: Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study
Contributors: Dirga Kumar Lamichhane, Dal-Young Jung, Yee-Jin Shin, Kyung-Sook Lee, So-Yeon Lee, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo-Jong Hong, Hwan-Cheol Kim, Kim, Kyung Won
Publisher Information: Urban & Fischer
Publication Year: 2021
Subject Terms: Air Pollutants* / analysis, Air Pollutants* / toxicity, Air Pollution* / analysis, Air Pollution* / statistics & numerical data, Anxiety / epidemiology, Cohort Studies, Environmental Exposure / analysis, Environmental Exposure / statistics & numerical data, Female, Humans, Nitrogen Dioxide / analysis, Nitrogen Dioxide / toxicity, Particulate Matter / analysis, Particulate Matter / toxicity, Pregnancy, Pregnant Women, Prospective Studies, Air pollution, Anxiety, Depression, Environment
Description: Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM10 RR = 1.13, 95% CI: 1.04, 1.23; NO2 RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women. ; open
Document Type: article in journal/newspaper
Language: English
Relation: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH; J03007; https://ir.ymlib.yonsei.ac.kr/handle/22282913/187772; T202125299
DOI: 10.1016/j.ijheh.2021.113823
Availability: https://ir.ymlib.yonsei.ac.kr/handle/22282913/187772
https://doi.org/10.1016/j.ijheh.2021.113823
Rights: CC BY-NC-ND 2.0 KR
Accession Number: edsbas.F132BF3E
Database: BASE
Description
Abstract:Background: Air pollution is associated with depressive and anxiety symptoms in the general population. However, this relationship among pregnant women remains largely unknown. Objective: To evaluate the association between pregnancy air pollution exposure and maternal depressive and anxiety symptoms during the third trimester assessed using the Center for Epidemiologic Studies-Depression and State-Trait Anxiety Inventory scales, respectively. Methods: We analyzed 1481 pregnant women from a cohort study in Seoul. Maternal exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) and <10 μm (PM10), as well as to nitrogen dioxide (NO2) and ozone (O3) for each trimester and the entire pregnancy was assessed at participant's residential address by land use regression models. We estimated the relative risk (RR) and corresponding confidence interval (CI) of the depressive and anxiety symptoms associated with an interquartile range (IQR) increase in PM2.5, PM10, NO2, and O3 using modified Poisson regression. Results: In single-pollutant models, an IQR increase in PM2.5, PM10, and NO2 during the second trimester was associated with an increased risk of depressive symptoms (PM2.5 RR = 1.15, 95% CI: 1.04, 1.27; PM10 RR = 1.13, 95% CI: 1.04, 1.23; NO2 RR = 1.15, 95% CI: 1.03, 1.29) after adjusting for relevant covariates. Similarly, an IQR increase in O3 during the third trimester was associated with an increased risk of depressive symptoms (RR = 1.09, 95% CI: 1.01, 1.18), while the IQR increase in O3 during the first trimester was associated with a decreased risk (RR = 0.89, 95% CI: 0.82, 0.96). Exposure to PM2.5, PM10, and NO2 during the second trimester was significantly associated with anxiety symptoms. The associations with PM2.5 and O3 in single-and multi-pollutant models were consistent. Conclusions: Our findings indicate that increased levels of particulate matter, NO2, and O3 during pregnancy may elevate the risk of depression or anxiety in pregnant women. ; open
DOI:10.1016/j.ijheh.2021.113823