Zobrazit v EDS

Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients

Uloženo v:
Podrobná bibliografie
Název: Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients
Autoři: Adianes Herrera-Diaz, Rober Boshra, Richard Kolesar, Netri Pajankar, Paniz Tavakoli, Chia-Yu Lin, Alison Fox-Robichaud, John F. Connolly
Zdroj: Brain Sciences ; Volume 15 ; Issue 2 ; Pages: 189
Informace o vydavateli: Multidisciplinary Digital Publishing Institute
Rok vydání: 2025
Sbírka: MDPI Open Access Publishing
Témata: event-related potentials, ERP, coma, disorders of consciousness, multivariate decoding, MVPA, mismatch negativity (MMN)
Popis: Background/Objectives: Coma prognosis is challenging, as patient presentation can be misleading or uninformative when using behavioral assessments only. Event-related potentials have been shown to provide valuable information about a patient’s chance of survival and emergence from coma. Our prior work revealed that the mismatch negativity (MMN) in particular waxes and wanes across 24 h in some coma patients. This “cycling” aspect of the presence/absence of neurophysiological responses may require fine-grained tools to increase the chances of detecting levels of neural processing in coma. This study implements multivariate pattern analysis (MVPA) to automatically quantify patterns of neural discrimination between duration deviant and standard tones over time at the single-subject level in seventeen healthy controls and in three comatose patients. Methods: One EEG recording, containing up to five blocks of an auditory oddball paradigm, was performed in controls over a 12 h period. For patients, two EEG sessions were conducted 3 days apart for up to 24 h, denoted as day 0 and day 3, respectively. MVPA was performed using a support-vector machine classifier. Results: Healthy controls exhibited reliable discrimination or classification performance during the latency intervals associated with MMN and P3a components. Two patients showed some intervals with significant discrimination around the second half of day 0, and all had significant results on day 3. Conclusions: These findings suggest that decoding analyses can accurately classify neural responses at a single-subject level in healthy controls and provide evidence of small but significant changes in auditory discrimination over time in coma patients. Further research is needed to confirm whether this approach represents an improved technology for assessing cognitive processing in coma.
Druh dokumentu: text
Popis souboru: application/pdf
Jazyk: English
Relation: Neurorehabilitation; https://dx.doi.org/10.3390/brainsci15020189
DOI: 10.3390/brainsci15020189
Dostupnost: https://doi.org/10.3390/brainsci15020189
Rights: https://creativecommons.org/licenses/by/4.0/
Přístupové číslo: edsbas.C4D33483
Databáze: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doi.org/10.3390/brainsci15020189#
    Name: EDS - BASE (s4221598)
    Category: fullText
    Text: View record from BASE
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Herrera-Diaz%20A
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsbas
DbLabel: BASE
An: edsbas.C4D33483
RelevancyScore: 997
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 996.707214355469
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Adianes+Herrera-Diaz%22">Adianes Herrera-Diaz</searchLink><br /><searchLink fieldCode="AR" term="%22Rober+Boshra%22">Rober Boshra</searchLink><br /><searchLink fieldCode="AR" term="%22Richard+Kolesar%22">Richard Kolesar</searchLink><br /><searchLink fieldCode="AR" term="%22Netri+Pajankar%22">Netri Pajankar</searchLink><br /><searchLink fieldCode="AR" term="%22Paniz+Tavakoli%22">Paniz Tavakoli</searchLink><br /><searchLink fieldCode="AR" term="%22Chia-Yu+Lin%22">Chia-Yu Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Alison+Fox-Robichaud%22">Alison Fox-Robichaud</searchLink><br /><searchLink fieldCode="AR" term="%22John+F%2E+Connolly%22">John F. Connolly</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Brain Sciences ; Volume 15 ; Issue 2 ; Pages: 189
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Multidisciplinary Digital Publishing Institute
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: MDPI Open Access Publishing
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22event-related+potentials%22">event-related potentials</searchLink><br /><searchLink fieldCode="DE" term="%22ERP%22">ERP</searchLink><br /><searchLink fieldCode="DE" term="%22coma%22">coma</searchLink><br /><searchLink fieldCode="DE" term="%22disorders+of+consciousness%22">disorders of consciousness</searchLink><br /><searchLink fieldCode="DE" term="%22multivariate+decoding%22">multivariate decoding</searchLink><br /><searchLink fieldCode="DE" term="%22MVPA%22">MVPA</searchLink><br /><searchLink fieldCode="DE" term="%22mismatch+negativity+%28MMN%29%22">mismatch negativity (MMN)</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background/Objectives: Coma prognosis is challenging, as patient presentation can be misleading or uninformative when using behavioral assessments only. Event-related potentials have been shown to provide valuable information about a patient’s chance of survival and emergence from coma. Our prior work revealed that the mismatch negativity (MMN) in particular waxes and wanes across 24 h in some coma patients. This “cycling” aspect of the presence/absence of neurophysiological responses may require fine-grained tools to increase the chances of detecting levels of neural processing in coma. This study implements multivariate pattern analysis (MVPA) to automatically quantify patterns of neural discrimination between duration deviant and standard tones over time at the single-subject level in seventeen healthy controls and in three comatose patients. Methods: One EEG recording, containing up to five blocks of an auditory oddball paradigm, was performed in controls over a 12 h period. For patients, two EEG sessions were conducted 3 days apart for up to 24 h, denoted as day 0 and day 3, respectively. MVPA was performed using a support-vector machine classifier. Results: Healthy controls exhibited reliable discrimination or classification performance during the latency intervals associated with MMN and P3a components. Two patients showed some intervals with significant discrimination around the second half of day 0, and all had significant results on day 3. Conclusions: These findings suggest that decoding analyses can accurately classify neural responses at a single-subject level in healthy controls and provide evidence of small but significant changes in auditory discrimination over time in coma patients. Further research is needed to confirm whether this approach represents an improved technology for assessing cognitive processing in coma.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: text
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: application/pdf
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: Neurorehabilitation; https://dx.doi.org/10.3390/brainsci15020189
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3390/brainsci15020189
– Name: URL
  Label: Availability
  Group: URL
  Data: https://doi.org/10.3390/brainsci15020189
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: https://creativecommons.org/licenses/by/4.0/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.C4D33483
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.C4D33483
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/brainsci15020189
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: event-related potentials
        Type: general
      – SubjectFull: ERP
        Type: general
      – SubjectFull: coma
        Type: general
      – SubjectFull: disorders of consciousness
        Type: general
      – SubjectFull: multivariate decoding
        Type: general
      – SubjectFull: MVPA
        Type: general
      – SubjectFull: mismatch negativity (MMN)
        Type: general
    Titles:
      – TitleFull: Decoding Analyses Show Dynamic Waxing and Waning of Event-Related Potentials in Coma Patients
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Adianes Herrera-Diaz
      – PersonEntity:
          Name:
            NameFull: Rober Boshra
      – PersonEntity:
          Name:
            NameFull: Richard Kolesar
      – PersonEntity:
          Name:
            NameFull: Netri Pajankar
      – PersonEntity:
          Name:
            NameFull: Paniz Tavakoli
      – PersonEntity:
          Name:
            NameFull: Chia-Yu Lin
      – PersonEntity:
          Name:
            NameFull: Alison Fox-Robichaud
      – PersonEntity:
          Name:
            NameFull: John F. Connolly
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: Brain Sciences ; Volume 15 ; Issue 2 ; Pages: 189
              Type: main
ResultId 1