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DQ beta polymorphism and genetic susceptibility to Felty's syndrome

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Název: DQ beta polymorphism and genetic susceptibility to Felty's syndrome
Autoři: So, A. K., Warner, C. A., Sansom, D., Walport, M. J.
Rok vydání: 2025
Sbírka: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Témata: Arthritis, Rheumatoid/*genetics Disease Susceptibility Felty's Syndrome/*genetics HLA-D Antigens/*genetics HLA-DQ Antigens/*genetics HLA-DR Antigens/genetics HLA-DR4 Antigen Haplotypes Humans Nucleic Acid Hybridization Oligonucleotides *Polymorphism, Genetic
Popis: We used an oligonucleotide probe specific for a polymorphic sequence in the HLA-DQ beta gene to investigate the role of DQ polymorphism in genetic susceptibility to Felty's syndrome (FS) and rheumatoid arthritis (RA). The sequence of this gene was identified from a complementary DNA library derived from an RA patient's B lymphoblastoid cell line. With this probe, we studied the prevalence of the specific DQ beta allele in DR4 positive FS patients, RA patients, and normal control subjects. Significantly more FS patients (17 of 25) showed hybridization with this oligonucleotide probe, compared with the number of DR4 positive non-FS RA patients (7 of 23) and normal controls (7 of 21). The findings indicate that genes linked to the DQ region are important in determining susceptibility to FS.
Druh dokumentu: article in journal/newspaper
Jazyk: unknown
ISSN: 0004-3591
Relation: Arthritis & rheumatism; https://iris.unil.ch/handle/iris/190063; serval:BIB_A70F20E656B9; A1988P676400008; 3261592
Dostupnost: https://iris.unil.ch/handle/iris/190063
Přístupové číslo: edsbas.C165721D
Databáze: BASE
Popis
Abstrakt:We used an oligonucleotide probe specific for a polymorphic sequence in the HLA-DQ beta gene to investigate the role of DQ polymorphism in genetic susceptibility to Felty's syndrome (FS) and rheumatoid arthritis (RA). The sequence of this gene was identified from a complementary DNA library derived from an RA patient's B lymphoblastoid cell line. With this probe, we studied the prevalence of the specific DQ beta allele in DR4 positive FS patients, RA patients, and normal control subjects. Significantly more FS patients (17 of 25) showed hybridization with this oligonucleotide probe, compared with the number of DR4 positive non-FS RA patients (7 of 23) and normal controls (7 of 21). The findings indicate that genes linked to the DQ region are important in determining susceptibility to FS.
ISSN:00043591