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The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study.

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Bibliographic Details
Title: The relative risk of second primary cancers in Switzerland: a population-based retrospective cohort study.
Authors: Feller, A., Matthes, K.L., Bordoni, A., Bouchardy, C., Bulliard, J.L., Herrmann, C., Konzelmann, I., Maspoli, M., Mousavi, M., Rohrmann, S., Staehelin, K., Arndt, V.
Contributors: NICER Working Group
Publication Year: 2025
Collection: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Subject Terms: Adolescent, Adult, Aged, Alcohol Drinking/adverse effects, Cancer Survivors/statistics & numerical data, Female, Humans, Incidence, Male, Middle Aged, Neoplasms/complications, Neoplasms/therapy, Neoplasms, Second Primary/epidemiology, Second Primary/etiology, Second Primary/pathology, Registries, Retrospective Studies, Risk Factors, Smoking/adverse effects, Switzerland/epidemiology, Young Adult, Cohort study, Relative risk, Retrospective, Second primary cancer, Switzerland
Description: More people than ever before are currently living with a diagnosis of cancer and the number of people concerned is likely to continue to rise. Cancer survivors are at risk of developing a second primary cancer (SPC). This study aims to investigate the risk of SPC in Switzerland. The study cohort included all patients with a first primary cancer recorded in 9 Swiss population-based cancer registries 1981-2009 who had a minimum survival of 6 months, and a potential follow-up until the end of 2014. We calculated standardized incidence ratios (SIR) to estimate relative risks (RR) of SPC in cancer survivors compared with the cancer risk of the general population. SIR were stratified by type of first cancer, sex, age and period of first diagnosis, survival period and site of SPC. A total of 33,793 SPC were observed in 310,113 cancer patients. Both male (SIR 1.18, 95%CI 1.16-1.19) and female (SIR 1.20, 95%CI 1.18-1.22) cancer survivors had an elevated risk of developing a SPC. Risk estimates varied substantially according to type of first cancer and were highest in patients initially diagnosed with cancer of the oral cavity and pharynx, Hodgkin lymphoma, laryngeal, oesophageal, or lung cancer. Age-stratified analyses revealed a tendency towards higher RR in patients first diagnosed at younger ages. Stratified by survival period, risk estimates showed a rising trend with increasing time from the initial diagnosis. We observed strong associations between particular types of first and SPC, i.e. cancer types sharing common risk factors such as smoking or alcohol consumption (e.g. repeated cancer of the oral cavity and pharynx (SIR males 20.12, 95%CI 17.91-22.33; SIR females 37.87, 95%CI 30.27-45.48). Swiss cancer survivors have an increased risk of developing a SPC compared to the general population, particularly patients first diagnosed before age 50 and those surviving more than 10 years. Cancer patients should remain under continued surveillance not only for recurrent cancers but also for new cancers. Some first and ...
Document Type: article in journal/newspaper
File Description: application/pdf
Language: English
ISSN: 1471-2407
Relation: BMC Cancer; https://iris.unil.ch/handle/iris/66180; serval:BIB_309F3E21A26F; 000513588000001
DOI: 10.1186/s12885-019-6452-0
Availability: https://iris.unil.ch/handle/iris/66180
https://doi.org/10.1186/s12885-019-6452-0
Accession Number: edsbas.C13E4F67
Database: BASE
Description
Abstract:More people than ever before are currently living with a diagnosis of cancer and the number of people concerned is likely to continue to rise. Cancer survivors are at risk of developing a second primary cancer (SPC). This study aims to investigate the risk of SPC in Switzerland. The study cohort included all patients with a first primary cancer recorded in 9 Swiss population-based cancer registries 1981-2009 who had a minimum survival of 6 months, and a potential follow-up until the end of 2014. We calculated standardized incidence ratios (SIR) to estimate relative risks (RR) of SPC in cancer survivors compared with the cancer risk of the general population. SIR were stratified by type of first cancer, sex, age and period of first diagnosis, survival period and site of SPC. A total of 33,793 SPC were observed in 310,113 cancer patients. Both male (SIR 1.18, 95%CI 1.16-1.19) and female (SIR 1.20, 95%CI 1.18-1.22) cancer survivors had an elevated risk of developing a SPC. Risk estimates varied substantially according to type of first cancer and were highest in patients initially diagnosed with cancer of the oral cavity and pharynx, Hodgkin lymphoma, laryngeal, oesophageal, or lung cancer. Age-stratified analyses revealed a tendency towards higher RR in patients first diagnosed at younger ages. Stratified by survival period, risk estimates showed a rising trend with increasing time from the initial diagnosis. We observed strong associations between particular types of first and SPC, i.e. cancer types sharing common risk factors such as smoking or alcohol consumption (e.g. repeated cancer of the oral cavity and pharynx (SIR males 20.12, 95%CI 17.91-22.33; SIR females 37.87, 95%CI 30.27-45.48). Swiss cancer survivors have an increased risk of developing a SPC compared to the general population, particularly patients first diagnosed before age 50 and those surviving more than 10 years. Cancer patients should remain under continued surveillance not only for recurrent cancers but also for new cancers. Some first and ...
ISSN:14712407
DOI:10.1186/s12885-019-6452-0