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Experimental test of ensemble inequivalence and the fluctuation theorem in the force ensemble in DNA pulling experiments

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Název: Experimental test of ensemble inequivalence and the fluctuation theorem in the force ensemble in DNA pulling experiments
Autoři: Martínez Monge, Álvaro, Mañosas Castejón, María, Ritort Farran, Fèlix
Zdroj: Articles publicats en revistes (Física de la Matèria Condensada)
Informace o vydavateli: American Physical Society
Rok vydání: 2018
Sbírka: Dipòsit Digital de la Universitat de Barcelona
Témata: Aparells i instruments científics, Dispositius optoelectrònics, Mecànica estadística, Scientific apparatus and instruments, Optoelectronic devices, Statistical mechanics
Popis: We experimentally test the validity of the Crooks fluctuation theorem (CFT) in the force ensemble by pulling DNA hairpins, first with magnetic tweezers, next with optical tweezers using force feedback. The CFT holds when using the definition of work Wf=−∫xdf, where x is the molecular extension and f is the force. In contrast, it does not hold when using the usual definition, appropriate for the constant extension ensemble, Wx=∫fdx, showing the importance of the contribution of boundary terms to the full entropy production in a clear example of statistical ensemble inequivalence in small systems. We also evaluate the differences in the average dissipated work in the force ensemble as compared to the extension ensemble, highlighting ensemble inequivalence also at the level of molecular kinetics.
Druh dokumentu: article in journal/newspaper
Popis souboru: 9 p.; application/pdf
Jazyk: English
Relation: Reproducció del document publicat a: https://doi.org/10.1103/PhysRevE.98.032146; Physical Review E, 2018, vol. 98, num. 3; https://doi.org/10.1103/PhysRevE.98.032146; info:eu-repo/grantAgreement/EC/H2020/687089/EU//PROSEQO; https://hdl.handle.net/2445/125334; 682359
Dostupnost: https://hdl.handle.net/2445/125334
Rights: (c) American Physical Society, 2018 ; info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.9D4B5E16
Databáze: BASE
Popis
Abstrakt:We experimentally test the validity of the Crooks fluctuation theorem (CFT) in the force ensemble by pulling DNA hairpins, first with magnetic tweezers, next with optical tweezers using force feedback. The CFT holds when using the definition of work Wf=−∫xdf, where x is the molecular extension and f is the force. In contrast, it does not hold when using the usual definition, appropriate for the constant extension ensemble, Wx=∫fdx, showing the importance of the contribution of boundary terms to the full entropy production in a clear example of statistical ensemble inequivalence in small systems. We also evaluate the differences in the average dissipated work in the force ensemble as compared to the extension ensemble, highlighting ensemble inequivalence also at the level of molecular kinetics.