Thermoresponsive “Click” Core@shell Poly(cyanoacrylate) Nanoparticles for Controlled Chemotherapy Release
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| Název: | Thermoresponsive “Click” Core@shell Poly(cyanoacrylate) Nanoparticles for Controlled Chemotherapy Release |
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| Autoři: | Cara Moloney, Dermot F. Brougham |
| Rok vydání: | 2025 |
| Témata: | Biophysics, Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Ecology, Inorganic Chemistry, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, synthesis without altering, suppressed diffusive processes, free induction time, enabled subsequent grafting, physiological conditions following, subsequent accelerated release, stimulated release applications, provide reversible temperature, following shell formation, chemotherapy drug daunorubicin, release cargo molecules, physiological temperature, unprecedented release, room temperature, shell thicknesses, thermoresponsive polymers, predictable delay, particle size, n <, multiple types |
| Popis: | Carriers that release cargo molecules over extended times under physiological conditions following a predictable delay, but which are also stable/have shelf life without release, are needed for chemotherapy. We report the preparation and characterization of poly(cyanoacrylate) core@shell nanoparticles as burst-free thermoresponsive drug delivery systems. Extraordinarily monodisperse poly( n -butyl cyanoacrylate)@poly(allyl cyanoacrylate) nanoparticles were prepared with control over the core size and shell thicknesses. Phenolphthalein, a model dye, or the chemotherapy drug daunorubicin was loaded into the cores during the synthesis without altering the particle size or colloidal stability. Following shell formation, transformation of accessible surface allyl groups in the shells to epoxide functionalities (i) enabled subsequent grafting with poly(ethylene glycol) for extending blood circulation time, or with thermoresponsive polymers to provide reversible temperature-dependent aggregation/colloidal destabilization, and (ii) suppressed diffusive processes, limiting the release at room temperature and providing an unprecedented release-free induction time with subsequent accelerated release at physiological temperature. The potential of core@shell poly(cyanoacrylate) NPs for stimulated release applications for multiple types of cargo is discussed. |
| Druh dokumentu: | article in journal/newspaper |
| Jazyk: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Thermoresponsive_Click_Core_shell_Poly_cyanoacrylate_Nanoparticles_for_Controlled_Chemotherapy_Release/29812976 |
| DOI: | 10.1021/acsanm.5c02620.s001 |
| Dostupnost: | https://doi.org/10.1021/acsanm.5c02620.s001 https://figshare.com/articles/journal_contribution/Thermoresponsive_Click_Core_shell_Poly_cyanoacrylate_Nanoparticles_for_Controlled_Chemotherapy_Release/29812976 |
| Rights: | CC BY-NC 4.0 |
| Přístupové číslo: | edsbas.848D7DB7 |
| Databáze: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | Carriers that release cargo molecules over extended times under physiological conditions following a predictable delay, but which are also stable/have shelf life without release, are needed for chemotherapy. We report the preparation and characterization of poly(cyanoacrylate) core@shell nanoparticles as burst-free thermoresponsive drug delivery systems. Extraordinarily monodisperse poly( n -butyl cyanoacrylate)@poly(allyl cyanoacrylate) nanoparticles were prepared with control over the core size and shell thicknesses. Phenolphthalein, a model dye, or the chemotherapy drug daunorubicin was loaded into the cores during the synthesis without altering the particle size or colloidal stability. Following shell formation, transformation of accessible surface allyl groups in the shells to epoxide functionalities (i) enabled subsequent grafting with poly(ethylene glycol) for extending blood circulation time, or with thermoresponsive polymers to provide reversible temperature-dependent aggregation/colloidal destabilization, and (ii) suppressed diffusive processes, limiting the release at room temperature and providing an unprecedented release-free induction time with subsequent accelerated release at physiological temperature. The potential of core@shell poly(cyanoacrylate) NPs for stimulated release applications for multiple types of cargo is discussed. |
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| DOI: | 10.1021/acsanm.5c02620.s001 |