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Vascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea

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Názov: Vascular and metabolic comorbidities in open-angle glaucoma with low- and high-teen intraocular pressure: a cross-sectional study from South Korea
Prispievatelia: College of Medicine, Dept. of Ophthalmology, Si Hyung Lee, Gyu Ah Kim, Wonseok Lee, Hyoung Won Bae, Gong Je Seong, Chan Yun Kim, Kim, Gyuah, Kim, Chan Yun, Bae, Hyoung Won, Seong, Gong Je, Lee, Si Hyung, Lee, Wonseok
Informácie o vydavateľovi: Blackwell Munksgaard
Rok vydania: 2017
Predmety: Adult, Aged, Comorbidity, Cross-Sectional Studies, Female, Glaucoma, Open-Angle/epidemiology, Open-Angle/physiopathology, Humans, Hyperlipidemias/epidemiology, Hypertension/epidemiology, Intraocular Pressure/physiology, Male, Middle Aged, Nutrition Surveys, Republic of Korea/epidemiology, Retrospective Studies, Risk Factors, diabetes, hyperlipidemia, hypertension, metabolic syndrome, normal-tension glaucoma
Popis: PURPOSE: To assess the associations between vascular and metabolic comorbidities and the prevalence of open-angle glaucoma (OAG) with low-teen and high-teen intraocular pressure (IOP) in Korea. METHODS: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low-teen IOP (IOP ≤ 15 mmHg) and high-teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low- and high-teen IOP groups. RESULTS: The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low-teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high-teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low-teen OAG was significantly associated with hypertension (OR, 1.68; 95% CI, 1.30-2.18), hyperlipidemia (OR, 1.49; 95% CI, 1.07-2.08), ischaemic heart disease (OR, 1.83; 95% CI, 1.07-3.11), stroke (OR, 1.91; 95% CI, 1.12-3.25) and metabolic syndrome (OR, 1.46; 95% CI, 1.12-1.90). High-teen OAG was only associated with stroke (OR, 2.58; 95% CI, 1.20-5.53). CONCLUSION: Various vascular and metabolic comorbidities were significantly associated with low-teen OAG, but not with high-teen OAG. These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low-teen baseline IOP. ; restriction
Druh dokumentu: article in journal/newspaper
Jazyk: English
Relation: ACTA OPHTHALMOLOGICA; J00025; https://ir.ymlib.yonsei.ac.kr/handle/22282913/161397; T201704725; 61315
DOI: 10.1111/aos.13487
Dostupnosť: https://ir.ymlib.yonsei.ac.kr/handle/22282913/161397
https://doi.org/10.1111/aos.13487
https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.13487
Rights: CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/
Prístupové číslo: edsbas.82892F5E
Databáza: BASE
Popis
Abstrakt:PURPOSE: To assess the associations between vascular and metabolic comorbidities and the prevalence of open-angle glaucoma (OAG) with low-teen and high-teen intraocular pressure (IOP) in Korea. METHODS: Cross-sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low-teen IOP (IOP ≤ 15 mmHg) and high-teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low- and high-teen IOP groups. RESULTS: The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low-teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high-teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low-teen OAG was significantly associated with hypertension (OR, 1.68; 95% CI, 1.30-2.18), hyperlipidemia (OR, 1.49; 95% CI, 1.07-2.08), ischaemic heart disease (OR, 1.83; 95% CI, 1.07-3.11), stroke (OR, 1.91; 95% CI, 1.12-3.25) and metabolic syndrome (OR, 1.46; 95% CI, 1.12-1.90). High-teen OAG was only associated with stroke (OR, 2.58; 95% CI, 1.20-5.53). CONCLUSION: Various vascular and metabolic comorbidities were significantly associated with low-teen OAG, but not with high-teen OAG. These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low-teen baseline IOP. ; restriction
DOI:10.1111/aos.13487