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Obesity-Related Kidney Disease: A Growing Threat to Renal Health

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Title: Obesity-Related Kidney Disease: A Growing Threat to Renal Health
Authors: León-Román, Juan, Esteves, Alexandra, Alvarez, Tiffany, López-Martínez, Marina, Ciudin Mihai, Andreea, Núñez Delgado, Sara, Soler, María José, Lecube, Albert
Contributors: Institut Català de la Salut, León-Román J, López-Martínez M, Núñez-Delgado S, Soler MJ Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Esteves A Nephrology Department, Hospitais da Univerisdade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal. Ciudin A Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERDEM (Instituto de Salud Carlos III), Madrid, Spain. Álvarez T Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CSUR National Unit of Expertise for Complex Glomerular Diseases of Spain, Barcelona, Spain. Lecube A Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Source: Scientia
Publisher Information: MDPI
Publication Year: 2025
Subject Terms: Insuficiència renal crònica - Factors de risc, Sistema cardiovascular - Malalties - Factors de risc, Obesitat - Factors de risc, Inflamació, DISEASES::Cardiovascular Diseases, DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic, DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors, DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, ENFERMEDADES::enfermedades cardiovasculares, ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::insuficiencia renal crónica, ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo, ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación
Description: Cardiovascular disease; Kidney disease; Obesity ; Malaltia cardiovascular; Malaltia renal; Obesitat ; Enfermedad cardiovascular; Enfermedad renal; Obesidad ; Obesity represents a serious and growing disease worldwide. The pathophysiological changes secondary to chronic inflammation lead to the development of diseases that increase the morbidity and mortality of individuals. Chronic kidney disease (CKD) is a condition with deleterious effects that acts bidirectionally with obesity. From approximately 20% to 30% of individuals share phenotypes of CKD and obesity, increasing their cardiovascular risk and the risk of other complications. Obesity and CKD form a vicious cycle in which inflammation is the central axis of multiorgan damage. Despite increasing the risk of cardiac and renal mortality, CKD progresses in relation to body mass index and albuminuria. Nowadays, the implementation of the new medications aimed at mitigating the peak of inflammation is becoming a cornerstone of treatments for obesity, diabetes, cardiovascular diseases, and renal disease. ; This research was funded by, ISCIIII-FEDER and ISCIII RETICS REDinREN, grant number PI21/01292 and PI24/00852, INT24/00067, ERA PerMed JTC2022 grant number AC22/00029, Río Hortega CM23/00213, Marató TV3 421/C/2020, Marató TV3 215/C/2021, and RICORS RD21/0005/0016, RD24/0004/0031. Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), enfermedades glomerulares complejas.
Document Type: article in journal/newspaper
File Description: application/pdf
Language: English
ISSN: 40724891
Relation: International Journal of Molecular Sciences;26(14); https://doi.org/10.3390/ijms26146641; info:eu-repo/grantAgreement/ES/PE2017-2020/PI21%2F01292; https://hdl.handle.net/11351/13847; 001535875300001
DOI: 10.3390/ijms26146641
Availability: https://hdl.handle.net/11351/13847
https://doi.org/10.3390/ijms26146641
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
Accession Number: edsbas.6B7E79A8
Database: BASE
Description
Abstract:Cardiovascular disease; Kidney disease; Obesity ; Malaltia cardiovascular; Malaltia renal; Obesitat ; Enfermedad cardiovascular; Enfermedad renal; Obesidad ; Obesity represents a serious and growing disease worldwide. The pathophysiological changes secondary to chronic inflammation lead to the development of diseases that increase the morbidity and mortality of individuals. Chronic kidney disease (CKD) is a condition with deleterious effects that acts bidirectionally with obesity. From approximately 20% to 30% of individuals share phenotypes of CKD and obesity, increasing their cardiovascular risk and the risk of other complications. Obesity and CKD form a vicious cycle in which inflammation is the central axis of multiorgan damage. Despite increasing the risk of cardiac and renal mortality, CKD progresses in relation to body mass index and albuminuria. Nowadays, the implementation of the new medications aimed at mitigating the peak of inflammation is becoming a cornerstone of treatments for obesity, diabetes, cardiovascular diseases, and renal disease. ; This research was funded by, ISCIIII-FEDER and ISCIII RETICS REDinREN, grant number PI21/01292 and PI24/00852, INT24/00067, ERA PerMed JTC2022 grant number AC22/00029, Río Hortega CM23/00213, Marató TV3 421/C/2020, Marató TV3 215/C/2021, and RICORS RD21/0005/0016, RD24/0004/0031. Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), enfermedades glomerulares complejas.
ISSN:40724891
DOI:10.3390/ijms26146641