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Molecular diagnosis in Allergology: application of the microarray tecnique

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Název: Molecular diagnosis in Allergology: application of the microarray tecnique
Autoři: Ferrer-Cardona, M. (Marta), Sanz, M.L. (María Luisa), Sastre, J. (Joaquín), Cuvillo, A. (A.) del, Montoro, J. (J.), Jauregui, I. (I.), Davila, I. (I.), Mullol, J. (J.), Valero-Santiago, A. (Antonio)
Informace o vydavateli: Esmon
Rok vydání: 2009
Sbírka: dadun - Depósito Académico Digital Universidad de Navarra
Témata: Hypersensitivity/diagnosis/immunology, Immunoglobulin E/analysis/immunology, Protein Array Analysis/methods
Popis: Recombinant and purified allergens are currently available for determining specific IgE targeted to different allergenic components. In this way it is possible to diagnose the sensitization profile of each individual patient. The microarray technique makes it possible to determine specific IgE against multiple allergens simultaneously in one same patient, with a minimum amount of serum, and even allows the determination of IgG and IgM against the same allergens in one same serum sample. Microarray procedures are being developed not only for the determination of antibodies but also for cell activation tests. In addition, microarray technology will help explain cross-reactions, and will facilitate the evaluation of subjects in which skin tests cannot be performed. These techniques will allow a great step forward in the development of immunotherapy specifically targeted to the sensitizations found in each individual patient, yielding especially hypoallergenic forms of great immunogenic capacity, and thus improving the safety and efficacy of immunotherapy. Lastly, microarrays will improve our understanding of the physiopathology of allergic diseases.
Druh dokumentu: article in journal/newspaper
Popis souboru: application/pdf
Jazyk: English
Relation: http://www.jiaci.org/issues/vol19s1/4.pdf; https://hdl.handle.net/10171/27559
Dostupnost: https://hdl.handle.net/10171/27559
Rights: info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.3F75389C
Databáze: BASE
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  – Url: https://hdl.handle.net/10171/27559#
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PubType: Academic Journal
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  Data: Molecular diagnosis in Allergology: application of the microarray tecnique
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  Data: <searchLink fieldCode="AR" term="%22Ferrer-Cardona%2C+M%2E+%28Marta%29%22">Ferrer-Cardona, M. (Marta)</searchLink><br /><searchLink fieldCode="AR" term="%22Sanz%2C+M%2EL%2E+%28María+Luisa%29%22">Sanz, M.L. (María Luisa)</searchLink><br /><searchLink fieldCode="AR" term="%22Sastre%2C+J%2E+%28Joaquín%29%22">Sastre, J. (Joaquín)</searchLink><br /><searchLink fieldCode="AR" term="%22Cuvillo%2C+A%2E+%28A%2E%29+del%22">Cuvillo, A. (A.) del</searchLink><br /><searchLink fieldCode="AR" term="%22Montoro%2C+J%2E+%28J%2E%29%22">Montoro, J. (J.)</searchLink><br /><searchLink fieldCode="AR" term="%22Jauregui%2C+I%2E+%28I%2E%29%22">Jauregui, I. (I.)</searchLink><br /><searchLink fieldCode="AR" term="%22Davila%2C+I%2E+%28I%2E%29%22">Davila, I. (I.)</searchLink><br /><searchLink fieldCode="AR" term="%22Mullol%2C+J%2E+%28J%2E%29%22">Mullol, J. (J.)</searchLink><br /><searchLink fieldCode="AR" term="%22Valero-Santiago%2C+A%2E+%28Antonio%29%22">Valero-Santiago, A. (Antonio)</searchLink>
– Name: Publisher
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  Data: Esmon
– Name: DatePubCY
  Label: Publication Year
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  Data: 2009
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  Data: dadun - Depósito Académico Digital Universidad de Navarra
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– Name: Abstract
  Label: Description
  Group: Ab
  Data: Recombinant and purified allergens are currently available for determining specific IgE targeted to different allergenic components. In this way it is possible to diagnose the sensitization profile of each individual patient. The microarray technique makes it possible to determine specific IgE against multiple allergens simultaneously in one same patient, with a minimum amount of serum, and even allows the determination of IgG and IgM against the same allergens in one same serum sample. Microarray procedures are being developed not only for the determination of antibodies but also for cell activation tests. In addition, microarray technology will help explain cross-reactions, and will facilitate the evaluation of subjects in which skin tests cannot be performed. These techniques will allow a great step forward in the development of immunotherapy specifically targeted to the sensitizations found in each individual patient, yielding especially hypoallergenic forms of great immunogenic capacity, and thus improving the safety and efficacy of immunotherapy. Lastly, microarrays will improve our understanding of the physiopathology of allergic diseases.
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  Data: http://www.jiaci.org/issues/vol19s1/4.pdf; https://hdl.handle.net/10171/27559
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  Data: https://hdl.handle.net/10171/27559
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      – Text: English
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        Type: general
      – SubjectFull: Immunoglobulin E/analysis/immunology
        Type: general
      – SubjectFull: Protein Array Analysis/methods
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      – TitleFull: Molecular diagnosis in Allergology: application of the microarray tecnique
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            NameFull: Ferrer-Cardona, M. (Marta)
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            NameFull: Sanz, M.L. (María Luisa)
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