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Development of a Holographic Sensor for Daylight Photodynamic Therapy Dosimetry

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Názov: Development of a Holographic Sensor for Daylight Photodynamic Therapy Dosimetry
Autori: Maher, Saoirse, McCavana, Jackie, Dr., Cournane, Seán, Dr., Martin, Suzanne, Cody, Dervil
Prispievatelia: Research Ireland, Government of Ireland Postgraduate Scholarship Programme
Zdroj: Articles
Informácie o vydavateľovi: Technological University Dublin
Rok vydania: 2025
Zbierka: Dublin Institute of Technology: ARROW@DIT (Archiving Research Resources on he Web)
Predmety: Holographic sensing, optical sensing, diffraction efficiency, phototherapy, daylight phototherapy treatment, Optics
Popis: Daylight photodynamic therapy, or D-PDT, uses a daylight-activated topical photosensitizing agent to target and kill cells. For successful drug activation, it is crucial to ensure that the treatment site receives sufficient daylight exposure, or daylight dose. Here, the development and optimization of a holographic transmission mode grating-based sensor for individualized D-PDT dosimetry is presented. The concept involves the use of a holographic grating, recorded in a photosensitive polymer-based film, which undergoes a measurable decrease in diffraction efficiency on exposure to daylight due to bleaching of the film and thus grating erasure. This low-cost, wearable sensor can be positioned on the patient’s skin adjacent to the D-PDT treatment site to measure the cumulative daylight dose at regular intervals during their treatment. Here, the formulation of the photosensitive film has been optimized to respond to daylight on relevant D-PDT time scales. Optimisation of the holographic grating parameters, such as grating thickness and spatial frequency, has led to improvements in initial diffraction efficiency and grating stability. Controlled grating erasure studies were carried out under various light exposure conditions: single wavelength, artificial white light, and daylight. A final sensor configuration which enables grating erasure on relevant D-PDT treatment time scales is described. The ability to modify the grating parameters and photosensitive material provides potential for adapting the technology to different photosensitizing agent types and weather conditions for a variety of visible light therapies.
Druh dokumentu: article in journal/newspaper
Jazyk: unknown
Relation: https://arrow.tudublin.ie/aaconmusart/48
DOI: 10.1021/acsaom.5c00405
DOI: 10.1021/acsaom.5c00405?casa_token=HbG5uWpl7RUAAAAA%3AwH9VHKeK6kA0hlkCDsUnEvtVTT96OipxXse4tgOMvcrzt874k1E3D0VtWYJBnhvOcoGpxC79hGeyZQ
Dostupnosť: https://arrow.tudublin.ie/aaconmusart/48
https://doi.org/10.1021/acsaom.5c00405
https://pubs.acs.org/doi/full/10.1021/acsaom.5c00405?casa_token=HbG5uWpl7RUAAAAA%3AwH9VHKeK6kA0hlkCDsUnEvtVTT96OipxXse4tgOMvcrzt874k1E3D0VtWYJBnhvOcoGpxC79hGeyZQ
Rights: http://creativecommons.org/licenses/by-nc-sa/4.0/
Prístupové číslo: edsbas.3BC2F39F
Databáza: BASE
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1009.3056640625
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development of a Holographic Sensor for Daylight Photodynamic Therapy Dosimetry
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Maher%2C+Saoirse%22">Maher, Saoirse</searchLink><br /><searchLink fieldCode="AR" term="%22McCavana%2C+Jackie%2C+Dr%2E%22">McCavana, Jackie, Dr.</searchLink><br /><searchLink fieldCode="AR" term="%22Cournane%2C+Seán%2C+Dr%2E%22">Cournane, Seán, Dr.</searchLink><br /><searchLink fieldCode="AR" term="%22Martin%2C+Suzanne%22">Martin, Suzanne</searchLink><br /><searchLink fieldCode="AR" term="%22Cody%2C+Dervil%22">Cody, Dervil</searchLink>
– Name: Author
  Label: Contributors
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  Data: Research Ireland<br />Government of Ireland Postgraduate Scholarship Programme
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  Data: Articles
– Name: Publisher
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  Data: Technological University Dublin
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2025
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  Data: Dublin Institute of Technology: ARROW@DIT (Archiving Research Resources on he Web)
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  Data: <searchLink fieldCode="DE" term="%22Holographic+sensing%22">Holographic sensing</searchLink><br /><searchLink fieldCode="DE" term="%22optical+sensing%22">optical sensing</searchLink><br /><searchLink fieldCode="DE" term="%22diffraction+efficiency%22">diffraction efficiency</searchLink><br /><searchLink fieldCode="DE" term="%22phototherapy%22">phototherapy</searchLink><br /><searchLink fieldCode="DE" term="%22daylight+phototherapy+treatment%22">daylight phototherapy treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Optics%22">Optics</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Daylight photodynamic therapy, or D-PDT, uses a daylight-activated topical photosensitizing agent to target and kill cells. For successful drug activation, it is crucial to ensure that the treatment site receives sufficient daylight exposure, or daylight dose. Here, the development and optimization of a holographic transmission mode grating-based sensor for individualized D-PDT dosimetry is presented. The concept involves the use of a holographic grating, recorded in a photosensitive polymer-based film, which undergoes a measurable decrease in diffraction efficiency on exposure to daylight due to bleaching of the film and thus grating erasure. This low-cost, wearable sensor can be positioned on the patient’s skin adjacent to the D-PDT treatment site to measure the cumulative daylight dose at regular intervals during their treatment. Here, the formulation of the photosensitive film has been optimized to respond to daylight on relevant D-PDT time scales. Optimisation of the holographic grating parameters, such as grating thickness and spatial frequency, has led to improvements in initial diffraction efficiency and grating stability. Controlled grating erasure studies were carried out under various light exposure conditions: single wavelength, artificial white light, and daylight. A final sensor configuration which enables grating erasure on relevant D-PDT treatment time scales is described. The ability to modify the grating parameters and photosensitive material provides potential for adapting the technology to different photosensitizing agent types and weather conditions for a variety of visible light therapies.
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  Data: article in journal/newspaper
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  Data: https://arrow.tudublin.ie/aaconmusart/48
– Name: DOI
  Label: DOI
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  Data: 10.1021/acsaom.5c00405
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  Data: 10.1021/acsaom.5c00405?casa_token=HbG5uWpl7RUAAAAA%3AwH9VHKeK6kA0hlkCDsUnEvtVTT96OipxXse4tgOMvcrzt874k1E3D0VtWYJBnhvOcoGpxC79hGeyZQ
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  Label: Availability
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  Data: https://arrow.tudublin.ie/aaconmusart/48<br />https://doi.org/10.1021/acsaom.5c00405<br />https://pubs.acs.org/doi/full/10.1021/acsaom.5c00405?casa_token=HbG5uWpl7RUAAAAA%3AwH9VHKeK6kA0hlkCDsUnEvtVTT96OipxXse4tgOMvcrzt874k1E3D0VtWYJBnhvOcoGpxC79hGeyZQ
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  Data: http://creativecommons.org/licenses/by-nc-sa/4.0/
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  Data: edsbas.3BC2F39F
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1021/acsaom.5c00405
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    Subjects:
      – SubjectFull: Holographic sensing
        Type: general
      – SubjectFull: optical sensing
        Type: general
      – SubjectFull: diffraction efficiency
        Type: general
      – SubjectFull: phototherapy
        Type: general
      – SubjectFull: daylight phototherapy treatment
        Type: general
      – SubjectFull: Optics
        Type: general
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      – TitleFull: Development of a Holographic Sensor for Daylight Photodynamic Therapy Dosimetry
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              Y: 2025
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