Combined Treatment with Immunotherapy-Based Strategies for MSS Metastatic Colorectal Cancer
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| Titel: | Combined Treatment with Immunotherapy-Based Strategies for MSS Metastatic Colorectal Cancer |
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| Autoren: | Baraibar Argota, Iosune, Mirallas Viñas, Oriol, Ros Montañá, Fco. Javier, Salva Ballabrera, Francesc, Tabernero Caturla, Josep, Elez Fernandez, Mª Elena, Saoudi Gonzalez, Nadia |
| Weitere Verfasser: | Institut Català de la Salut, Baraibar I, Saoudi N, Ros J, Salvà F, Tabernero J, Élez E Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Mirallas O Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Quelle: | Scientia |
| Verlagsinformationen: | MDPI |
| Publikationsjahr: | 2021 |
| Schlagwörter: | Còlon - Càncer - Tractament, Recte - Càncer - Tractament, Immunoteràpia, DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms, Other subheadings::Other subheadings::Other subheadings::/drug therapy, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy, AND EQUIPMENT::Therapeutics::Combined Modality Therapy, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::tratamiento combinado |
| Beschreibung: | Colorectal cancer; Combined treatment; Immune checkpoint inhibitors ; Cáncer colorrectal; Tratamiento combinado; Inhibidores de puntos de control inmunitarios ; Càncer colorectal; Tractament combinat; Inhibidors de punts de control immunitaris ; In recent years, deepening knowledge of the complex interactions between the immune system and cancer cells has led to the advent of effective immunotherapies that have revolutionized the therapeutic paradigm of several cancer types. However, colorectal cancer (CRC) is one of the tumor types in which immunotherapy has proven less effective. While there is solid clinical evidence for the therapeutic role of immune checkpoint inhibitors in mismatch repair-deficient (dMMR) and in highly microsatellite instable (MSI-H) metastatic CRC (mCRC), blockade of CTLA-4 or PD-L1/PD-1 as monotherapy has not conferred any major clinical benefit to patients with MMR-proficient (pMMR) or microsatellite stable (MSS) mCRC, reflecting 95% of the CRC population. There thus remains a high unmet medical need for the development of novel immunotherapy approaches for the vast majority of patients with pMMR or MSS/MSI-low (MSI-L) mCRC. Defining the molecular mechanisms for immunogenicity in mCRC and mediating immune resistance in MSS mCRC is needed to develop predictive biomarkers and effective therapeutic combination strategies. Here we review available clinical data from combinatorial therapeutic approaches using immunotherapy-based strategies for MSS mCRC. |
| Publikationsart: | article in journal/newspaper |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 34944931 |
| Relation: | Cancers;13(24); https://doi.org/10.3390/cancers13246311; https://hdl.handle.net/11351/7636; 000741497900001 |
| DOI: | 10.3390/cancers13246311 |
| Verfügbarkeit: | https://hdl.handle.net/11351/7636 https://doi.org/10.3390/cancers13246311 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| Dokumentencode: | edsbas.34180991 |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Colorectal cancer; Combined treatment; Immune checkpoint inhibitors ; Cáncer colorrectal; Tratamiento combinado; Inhibidores de puntos de control inmunitarios ; Càncer colorectal; Tractament combinat; Inhibidors de punts de control immunitaris ; In recent years, deepening knowledge of the complex interactions between the immune system and cancer cells has led to the advent of effective immunotherapies that have revolutionized the therapeutic paradigm of several cancer types. However, colorectal cancer (CRC) is one of the tumor types in which immunotherapy has proven less effective. While there is solid clinical evidence for the therapeutic role of immune checkpoint inhibitors in mismatch repair-deficient (dMMR) and in highly microsatellite instable (MSI-H) metastatic CRC (mCRC), blockade of CTLA-4 or PD-L1/PD-1 as monotherapy has not conferred any major clinical benefit to patients with MMR-proficient (pMMR) or microsatellite stable (MSS) mCRC, reflecting 95% of the CRC population. There thus remains a high unmet medical need for the development of novel immunotherapy approaches for the vast majority of patients with pMMR or MSS/MSI-low (MSI-L) mCRC. Defining the molecular mechanisms for immunogenicity in mCRC and mediating immune resistance in MSS mCRC is needed to develop predictive biomarkers and effective therapeutic combination strategies. Here we review available clinical data from combinatorial therapeutic approaches using immunotherapy-based strategies for MSS mCRC. |
|---|---|
| ISSN: | 34944931 |
| DOI: | 10.3390/cancers13246311 |