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Quantitation of HBF gamma-chain types by HPLC in patients with myelodysplastic syndrome

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Název: Quantitation of HBF gamma-chain types by HPLC in patients with myelodysplastic syndrome
Autoři: Bourantas, K. L., Georgiou, I., Seferiadis, K.
Zdroj: Haematologica. 76(4)
Informace o vydavateli: 1991.
Rok vydání: 1991
Témata: Adult, Male, Alanine, Glycine, Middle Aged, Prognosis, Alanine/analysis, Chromatography, High Pressure Liquid, Globins, Globins/*analysis, Glycine/analysis, Myelodysplastic Syndromes, Fetal Hemoglobin/*analysis, Humans, Female, Myelodysplastic Syndromes/*blood/mortality, Fetal Hemoglobin, Aged
Popis: High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemoglobinopathies was excluded. The fetal hemoglobin percentage was quantitated by alkali denaturation of the hemolysate, and the gamma chain content was determined in blood hemolysate by HPLC following HbF isolation. A 7/3 ratio of fetal Gy/Ay was found in three patients. Since the survival of MDS patients with high HbF levels was longer than that of patients with low levels of HbF, this finding may be used as a potential prognostic factor.
Druh dokumentu: Article
Jazyk: English
ISSN: 0390-6078
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/1724440
http://olympias.lib.uoi.gr/jspui/handle/123456789/18858
Přístupové číslo: edsair.pmid.dedup....4f748b8e7b6a59a6fc8557d951847f16
Databáze: OpenAIRE
Popis
Abstrakt:High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemoglobinopathies was excluded. The fetal hemoglobin percentage was quantitated by alkali denaturation of the hemolysate, and the gamma chain content was determined in blood hemolysate by HPLC following HbF isolation. A 7/3 ratio of fetal Gy/Ay was found in three patients. Since the survival of MDS patients with high HbF levels was longer than that of patients with low levels of HbF, this finding may be used as a potential prognostic factor.
ISSN:03906078