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Carbapenem-resistant Morganella morganii carrying blaKPC-2 or blaNDM-1 in the clinic: one-decade genomic epidemiology analysis

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Názov: Carbapenem-resistant Morganella morganii carrying blaKPC-2 or blaNDM-1 in the clinic: one-decade genomic epidemiology analysis
Autori: Jiayao Yao, Yueyue Hu, Xinru Wang, Jie Sheng, Ying Zhang, Xiaofei Zhao, Jiaqing Wang, Xiufang Xu, Xi Li
Zdroj: Microbiol Spectr
Microbiology Spectrum, Vol 13, Iss 4 (2025)
Informácie o vydavateľovi: American Society for Microbiology, 2025.
Rok vydania: 2025
Predmety: Morganella morganii, Cross Infection, phylogenetic analysis, Enterobacteriaceae Infections, Microbial Sensitivity Tests, Genomics, NDM-1, Microbiology, KPC-2, QR1-502, beta-Lactamases, Anti-Bacterial Agents, Klebsiella pneumoniae, Carbapenem-Resistant Enterobacteriaceae, Carbapenems, Bacterial Proteins, Humans, carbapenem-resistant Enterobacterales, Research Article, Plasmids
Popis: Carbapenem-resistant Morganella morganii (CRMM) isolates, particularly those producing Klebsiella pneumoniae carbapenemase-2 (KPC-2) or New Delhi metallo-β-lactamase-1 (NDM-1), are increasingly being recognized as causative agents of nosocomial infections. However, systematic phylogeography and genetic characterization of these isolates worldwide are still lacking. Here, through seven years of surveillance of CRMM in a tertiary hospital, we analyzed the genomic characteristics of blaKPC-2- or blaNDM-1-positive CRMM isolates. Furthermore, we conducted a global genomic epidemiological study of Morganella spp. harboring blaKPC or blaNDM using the NCBI database over the past decade. By combining the timeline of isolate collection with the structural analysis of the plasmids, we traced the evolution of the IncL/M plasmid, which acquired the blaKPC-2 gene. Our findings indicate that horizontal transfer of Tn6296 based on IS26 is crucial for the transmission of blaKPC in CRMM isolates. Additionally, the Tn125 transposon appears to have played an important role in early plasmid-mediated dissemination of blaNDM; however, it has been surpassed in recent years by other elements, including IS26 and ISCR. In summary, through phylogeographic analysis of Morganella spp. globally, we elucidated their spatial-temporal distribution and revealed the evolutionary characteristics of KPC- or NDM-producing CRMM isolates as the predominant "epidemic" clone.Currently, infections attributable to carbapenem-resistant Morganella morganii (CRMM) isolates harboring blaKPC or blaNDM are on the rise, highlighting the increasing severity of acquired antimicrobial resistance. However, systematic phylogeographic and genetic characterization of these isolates worldwide is still lacking. In this study, we elucidated the spatial-temporal distribution and evolutionary trajectory of blaKPC and blaNDM genes within their core genetic environments. We emphasize the necessity of strengthening surveillance and controlling these organisms in clinical settings to prevent the generation of so-called "superbug" isolates.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 2165-0497
DOI: 10.1128/spectrum.02476-24
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40029330
https://doaj.org/article/607b95f3299c4182ac82c95d2cfa614a
Rights: CC BY
Prístupové číslo: edsair.pmid.dedup....2c76beea00a6ea0dca02b7d46c105e90
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  Label: Title
  Group: Ti
  Data: Carbapenem-resistant Morganella morganii carrying blaKPC-2 or blaNDM-1 in the clinic: one-decade genomic epidemiology analysis
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Jiayao+Yao%22">Jiayao Yao</searchLink><br /><searchLink fieldCode="AR" term="%22Yueyue+Hu%22">Yueyue Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Xinru+Wang%22">Xinru Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Jie+Sheng%22">Jie Sheng</searchLink><br /><searchLink fieldCode="AR" term="%22Ying+Zhang%22">Ying Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaofei+Zhao%22">Xiaofei Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Jiaqing+Wang%22">Jiaqing Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiufang+Xu%22">Xiufang Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Xi+Li%22">Xi Li</searchLink>
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  Data: Microbiol Spectr<br />Microbiology Spectrum, Vol 13, Iss 4 (2025)
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  Data: American Society for Microbiology, 2025.
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22Morganella+morganii%22">Morganella morganii</searchLink><br /><searchLink fieldCode="DE" term="%22Cross+Infection%22">Cross Infection</searchLink><br /><searchLink fieldCode="DE" term="%22phylogenetic+analysis%22">phylogenetic analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Enterobacteriaceae+Infections%22">Enterobacteriaceae Infections</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+Sensitivity+Tests%22">Microbial Sensitivity Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Genomics%22">Genomics</searchLink><br /><searchLink fieldCode="DE" term="%22NDM-1%22">NDM-1</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiology%22">Microbiology</searchLink><br /><searchLink fieldCode="DE" term="%22KPC-2%22">KPC-2</searchLink><br /><searchLink fieldCode="DE" term="%22QR1-502%22">QR1-502</searchLink><br /><searchLink fieldCode="DE" term="%22beta-Lactamases%22">beta-Lactamases</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents</searchLink><br /><searchLink fieldCode="DE" term="%22Klebsiella+pneumoniae%22">Klebsiella pneumoniae</searchLink><br /><searchLink fieldCode="DE" term="%22Carbapenem-Resistant+Enterobacteriaceae%22">Carbapenem-Resistant Enterobacteriaceae</searchLink><br /><searchLink fieldCode="DE" term="%22Carbapenems%22">Carbapenems</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+Proteins%22">Bacterial Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22carbapenem-resistant+Enterobacterales%22">carbapenem-resistant Enterobacterales</searchLink><br /><searchLink fieldCode="DE" term="%22Research+Article%22">Research Article</searchLink><br /><searchLink fieldCode="DE" term="%22Plasmids%22">Plasmids</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Carbapenem-resistant Morganella morganii (CRMM) isolates, particularly those producing Klebsiella pneumoniae carbapenemase-2 (KPC-2) or New Delhi metallo-β-lactamase-1 (NDM-1), are increasingly being recognized as causative agents of nosocomial infections. However, systematic phylogeography and genetic characterization of these isolates worldwide are still lacking. Here, through seven years of surveillance of CRMM in a tertiary hospital, we analyzed the genomic characteristics of blaKPC-2- or blaNDM-1-positive CRMM isolates. Furthermore, we conducted a global genomic epidemiological study of Morganella spp. harboring blaKPC or blaNDM using the NCBI database over the past decade. By combining the timeline of isolate collection with the structural analysis of the plasmids, we traced the evolution of the IncL/M plasmid, which acquired the blaKPC-2 gene. Our findings indicate that horizontal transfer of Tn6296 based on IS26 is crucial for the transmission of blaKPC in CRMM isolates. Additionally, the Tn125 transposon appears to have played an important role in early plasmid-mediated dissemination of blaNDM; however, it has been surpassed in recent years by other elements, including IS26 and ISCR. In summary, through phylogeographic analysis of Morganella spp. globally, we elucidated their spatial-temporal distribution and revealed the evolutionary characteristics of KPC- or NDM-producing CRMM isolates as the predominant "epidemic" clone.Currently, infections attributable to carbapenem-resistant Morganella morganii (CRMM) isolates harboring blaKPC or blaNDM are on the rise, highlighting the increasing severity of acquired antimicrobial resistance. However, systematic phylogeographic and genetic characterization of these isolates worldwide is still lacking. In this study, we elucidated the spatial-temporal distribution and evolutionary trajectory of blaKPC and blaNDM genes within their core genetic environments. We emphasize the necessity of strengthening surveillance and controlling these organisms in clinical settings to prevent the generation of so-called "superbug" isolates.
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  Data: 10.1128/spectrum.02476-24
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    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Morganella morganii
        Type: general
      – SubjectFull: Cross Infection
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      – SubjectFull: phylogenetic analysis
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