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Tc-99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery

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Název: Tc-99m mebrofenin hepatobiliary scintigraphy to assess future liver remnant function before major liver surgery
Autoři: Smet, H., Uldry, E., Duran, R., Girardet, R., Schaefer, N., Prior, J.O., Denys, A., Halkic, N., Demartines, N., Melloul, E.
Zdroj: Journal of surgical oncology, vol. 128, no. 8, pp. 1312-1319
Informace o vydavateli: 2023.
Rok vydání: 2023
Témata: Humans, Liver Function Tests, Liver/diagnostic imaging, Liver/surgery, Hepatectomy/adverse effects, Hepatectomy/methods, Liver Failure/diagnostic imaging, Liver Failure/etiology, Radionuclide Imaging, Liver Neoplasms/surgery, Embolization, Therapeutic, Portal Vein/diagnostic imaging, Retrospective Studies, hepatectomy, hepatobiliary scintigraphy, liver failure, liver function test
Popis: Assessment of liver function is paramount before hepatectomy. This study aimed to assess future liver remnant function (FLR-F) using hepatobiliary scintigraphy (HBS) and to compare it to FLR volume (FLR-V) in the prediction of posthepatectomy liver failure (PHLF). The impact of volume and function gains were also assessed in patients undergoing portal vein embolization (PVE) or liver venous deprivation (LVD). All consecutive patients undergoing major hepatectomy between 02/2018 and 09/2021 with preoperative HBS were included. FLR-V was expressed as percentage of total liver volume and analyzed using preoperative computed tomography. FLR-V and FLR-F gains after embolization were expressed in percentage. Receiver operating characteristic analysis was performed to compare both methods in predicting PHLF. Thirty-six patients were included. PVE and LVD were performed in 4 (11%) and 28 patients (78%), respectively. Overall, PHLF occurred in eight patients (22%). FLR-F gain after embolization showed significant ability to predict PHLF (area under the curve [AUC] = 0.789), with cut-off value of 150% showing a sensitivity of 1.00, a specificity of 0.42, and a negative predictive value of 1.00. Preoperative HBS shows a high sensitivity to predict PHLF when HBS is performed twice to measure the function gain after venous embolization.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
Přístupová URL adresa: https://serval.unil.ch/resource/serval:BIB_320D6A0EAFB8.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_320D6A0EAFB8
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_320D6A0EAFB86
Rights: CC BY NC ND
Přístupové číslo: edsair.od......1900..af7dbe7def9d2e1f45112a8ca20d9e18
Databáze: OpenAIRE
Popis
Abstrakt:Assessment of liver function is paramount before hepatectomy. This study aimed to assess future liver remnant function (FLR-F) using hepatobiliary scintigraphy (HBS) and to compare it to FLR volume (FLR-V) in the prediction of posthepatectomy liver failure (PHLF). The impact of volume and function gains were also assessed in patients undergoing portal vein embolization (PVE) or liver venous deprivation (LVD). All consecutive patients undergoing major hepatectomy between 02/2018 and 09/2021 with preoperative HBS were included. FLR-V was expressed as percentage of total liver volume and analyzed using preoperative computed tomography. FLR-V and FLR-F gains after embolization were expressed in percentage. Receiver operating characteristic analysis was performed to compare both methods in predicting PHLF. Thirty-six patients were included. PVE and LVD were performed in 4 (11%) and 28 patients (78%), respectively. Overall, PHLF occurred in eight patients (22%). FLR-F gain after embolization showed significant ability to predict PHLF (area under the curve [AUC] = 0.789), with cut-off value of 150% showing a sensitivity of 1.00, a specificity of 0.42, and a negative predictive value of 1.00. Preoperative HBS shows a high sensitivity to predict PHLF when HBS is performed twice to measure the function gain after venous embolization.