In EDS ansehen

Outcomes of pacing in patients with cardiac amyloidosis - a single center experience

Gespeichert in:
Bibliographische Detailangaben
Titel: Outcomes of pacing in patients with cardiac amyloidosis - a single center experience
Autoren: Dispenzieri, A, Hai, SHJJ, Webster, TL, Brady, PA, Grogan, M, Lin, G
Verlagsinformationen: Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org, 2016.
Publikationsjahr: 2016
Beschreibung: BACKGROUND: Cardiac amyloidosis (CA) is associated with sinus node dysfunction (SND) and conduction system disease (CSD) yet data on pacing indications and outcomes is scarce. METHODS: Retrospective review of patients (pts) with CA who had device implantation due to pacing indication at our institution. RESULTS: At total of 51 (mean age 67.2±9.2 years, 90.2% male) pts with immunoglobulin light chain (n=27, 52.9%), hereditary transthyretin (n=7, 13.7%) and wild-type transthyretin (n=17, 33.3%) CA were included. Indication for pacing was exercise intolerance (n=16, 31.4%), syncope (n=16, 31.4%), congestive heart failure (n=5, 9.8%) and palpitation (n=2, 3.9%) with SND (n=23, 45.1%), CSD (17=33.3%) and uncontrolled atrial fibrillation (n=11, 21.6%). 16 (31.4%) pts received defibrillators (ICD) for primary prevention, of whom 8 (15.7%) had left ventricular ejection fraction (LVEF) ≤35%. Atrial (P wave: 1.7±1.2mV, threshold: 1.1±0.5mV/0.5±0.2ms) and right ventricular (RV) (R wave: 7.9±3.8mV, threshold: 0.8±0.4mV/0.4±0.1ms) lead parameters were satisfactory at implantation. During follow-up (mean 36.6±33.6 months), 26 (51%) pts reported symptomatic improvement (SI). Syncope was the only predictor of SI (OR 16.4, 95%CI 1.8-145.2, p=0.01) while exercise intolerance was not (OR 0.09, 95%CI 0.02-0.44, p=0.003). First-time life-threatening ventricular arrhythmias (VA) occurred in 6 (11.8%) pts, 3 (5.9%) had ICD implanted for LVEF ≤35%, 3 (5.9%) without ICD and LVEF ≥35%. Syncope was not predictive of first-time VA. RV lead noise led to inappropriate ICD shocks in 1 patient. Atrial lead sensing failure occurred in 6 (11.8%) and loss of capture in 5 (9.8%). CONCLUSION: Device implantation in patients with cardiac amyloidosis is safe but atrial lead failure is common. Syncope usually improves with pacing whereas other factors should be considered in those presented with exercise intolerance. Selection of pts who need pacing for prophylactic ICD implantation is challenging as neither left ventricular ejection fraction nor syncope are predictive of arrhythmic events.
Core 4. Heart Rhythm Disorders and Resuscitation Science - Session Title: What's New in Pacing
Open Access Journal
Publikationsart: Conference object
Sprache: English
Zugangs-URL: http://hdl.handle.net/10722/236460
Dokumentencode: edsair.od.......961..f315fb8c3d0b8b3d91a57d70c1fa540a
Datenbank: OpenAIRE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://explore.openaire.eu/search/publication?articleId=od_______961%3A%3Af315fb8c3d0b8b3d91a57d70c1fa540a
    Name: EDS - OpenAIRE (s4221598)
    Category: fullText
    Text: View record at OpenAIRE
  – Url: https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=EBSCO&SrcAuth=EBSCO&DestApp=WOS&ServiceName=TransferToWoS&DestLinkType=GeneralSearchSummary&Func=Links&author=Dispenzieri%20A
    Name: ISI
    Category: fullText
    Text: Nájsť tento článok vo Web of Science
    Icon: https://imagesrvr.epnet.com/ls/20docs.gif
    MouseOverText: Nájsť tento článok vo Web of Science
Header DbId: edsair
DbLabel: OpenAIRE
An: edsair.od.......961..f315fb8c3d0b8b3d91a57d70c1fa540a
RelevancyScore: 803
AccessLevel: 3
PubType: Conference
PubTypeId: conference
PreciseRelevancyScore: 802.552062988281
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Outcomes of pacing in patients with cardiac amyloidosis - a single center experience
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dispenzieri%2C+A%22">Dispenzieri, A</searchLink><br /><searchLink fieldCode="AR" term="%22Hai%2C+SHJJ%22">Hai, SHJJ</searchLink><br /><searchLink fieldCode="AR" term="%22Webster%2C+TL%22">Webster, TL</searchLink><br /><searchLink fieldCode="AR" term="%22Brady%2C+PA%22">Brady, PA</searchLink><br /><searchLink fieldCode="AR" term="%22Grogan%2C+M%22">Grogan, M</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+G%22">Lin, G</searchLink>
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org, 2016.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2016
– Name: Abstract
  Label: Description
  Group: Ab
  Data: BACKGROUND: Cardiac amyloidosis (CA) is associated with sinus node dysfunction (SND) and conduction system disease (CSD) yet data on pacing indications and outcomes is scarce. METHODS: Retrospective review of patients (pts) with CA who had device implantation due to pacing indication at our institution. RESULTS: At total of 51 (mean age 67.2±9.2 years, 90.2% male) pts with immunoglobulin light chain (n=27, 52.9%), hereditary transthyretin (n=7, 13.7%) and wild-type transthyretin (n=17, 33.3%) CA were included. Indication for pacing was exercise intolerance (n=16, 31.4%), syncope (n=16, 31.4%), congestive heart failure (n=5, 9.8%) and palpitation (n=2, 3.9%) with SND (n=23, 45.1%), CSD (17=33.3%) and uncontrolled atrial fibrillation (n=11, 21.6%). 16 (31.4%) pts received defibrillators (ICD) for primary prevention, of whom 8 (15.7%) had left ventricular ejection fraction (LVEF) ≤35%. Atrial (P wave: 1.7±1.2mV, threshold: 1.1±0.5mV/0.5±0.2ms) and right ventricular (RV) (R wave: 7.9±3.8mV, threshold: 0.8±0.4mV/0.4±0.1ms) lead parameters were satisfactory at implantation. During follow-up (mean 36.6±33.6 months), 26 (51%) pts reported symptomatic improvement (SI). Syncope was the only predictor of SI (OR 16.4, 95%CI 1.8-145.2, p=0.01) while exercise intolerance was not (OR 0.09, 95%CI 0.02-0.44, p=0.003). First-time life-threatening ventricular arrhythmias (VA) occurred in 6 (11.8%) pts, 3 (5.9%) had ICD implanted for LVEF ≤35%, 3 (5.9%) without ICD and LVEF ≥35%. Syncope was not predictive of first-time VA. RV lead noise led to inappropriate ICD shocks in 1 patient. Atrial lead sensing failure occurred in 6 (11.8%) and loss of capture in 5 (9.8%). CONCLUSION: Device implantation in patients with cardiac amyloidosis is safe but atrial lead failure is common. Syncope usually improves with pacing whereas other factors should be considered in those presented with exercise intolerance. Selection of pts who need pacing for prophylactic ICD implantation is challenging as neither left ventricular ejection fraction nor syncope are predictive of arrhythmic events.<br />Core 4. Heart Rhythm Disorders and Resuscitation Science - Session Title: What's New in Pacing<br />Open Access Journal
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: Conference object
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="http://hdl.handle.net/10722/236460" linkWindow="_blank">http://hdl.handle.net/10722/236460</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsair.od.......961..f315fb8c3d0b8b3d91a57d70c1fa540a
PLink https://erproxy.cvtisr.sk/sfx/access?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.od.......961..f315fb8c3d0b8b3d91a57d70c1fa540a
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    Titles:
      – TitleFull: Outcomes of pacing in patients with cardiac amyloidosis - a single center experience
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dispenzieri, A
      – PersonEntity:
          Name:
            NameFull: Hai, SHJJ
      – PersonEntity:
          Name:
            NameFull: Webster, TL
      – PersonEntity:
          Name:
            NameFull: Brady, PA
      – PersonEntity:
          Name:
            NameFull: Grogan, M
      – PersonEntity:
          Name:
            NameFull: Lin, G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 11
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-locals
              Value: edsair
ResultId 1