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Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury

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Title: Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury
Authors: Haider, Achi, Bengs, Susan, Portmann, Angela, Fröhlich, Sandro, Etter, Dominik, Maredziak, Monika, Warnock, Geoffrey I, Akhmedov, Alexander, Kozerke, Sebastian, Keller, Claudia, Montecucco, Fabrizio, Weber, Bruno, Mu, Linjing, Buechel, Ronny R, Regitz-Zagrosek, Vera, Kaufmann, Philipp A, Camici, Giovanni G, Ametamey, Simon M, Gebhard, Catherine
Contributors: University of Zurich, Gebhard, Catherine
Source: Biol Sex Differ
Biology of Sex Differences, Vol 16, Iss 1, Pp 1-15 (2025)
Biology of Sex Differences, 16 (1)
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Aging, Sympathetic Nervous System, Physiology, Myocardial Infarction, 610 Medicine & health, Mice, QP1-981, Animals, Testosterone, Sex hormones, Myocardial infarction, Sex, [C-11]meta-hydroxyephedrine, Positron emission tomography (PET), Cardiac magnetic resonance (CMR) imaging, Sex Characteristics, Ventricular Remodeling, Research, Myocardium, Age Factors, Heart, 10181 Clinic for Nuclear Medicine, 1310 Endocrinology, [11C]meta-hydroxyephedrine, 3318 Gender Studies, Positron-Emission Tomography, Heart [MeSH], Ephedrine/analogs, Testosterone/blood [MeSH], Catecholamines/blood [MeSH], Myocardial Infarction/pathology [MeSH], Male [MeSH], Myocardial Infarction/physiopathology [MeSH], Catecholamines/metabolism [MeSH], Positron-Emission Tomography [MeSH], [, Aging/physiology [MeSH], Sex Characteristics [MeSH], Myocardium/metabolism [MeSH], Female [MeSH], Animals [MeSH], Myocardium/pathology [MeSH], Sympathetic Nervous System/physiopathology [MeSH], Mice [MeSH], Ventricular Remodeling [MeSH], Ephedrine/pharmacology [MeSH], Medicine, Female
Description: Background Presentations and outcomes of acute myocardial infarction (MI) differ between women and men, with the worst outcomes being reported in younger women. Mental stress induced ischemia and sympathetic activation have been suggested to play a prominent role in the pathogenesis of MI in younger women, however, the impact of sex hormones on these parameters remains unknown. Methods The effect of sex hormones and age on myocardial infarct size and myocardial sympathetic activity (MSA) was assessed in male and female, as well as young (4–6 months) and aged (20–22 months) FVB/N mice (n = 106, 60 gonadectomized and 46 sham-operated animals) who underwent in vivo [11C]meta-hydroxyephedrine ([11C]mHED) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging 24 h after a 30 min myocardial ischemic injury. Results MSA and catecholamine levels following myocardial injury were highest in young males (p = 0.008 and p = 0.043 vs. young females, respectively) and were reduced by orchiectomy. Accordingly, testosterone serum levels correlated positively with MSA (r = 0.66, p p p = 0.892). Female animals showed an age-dependent increase in MSA (p = 0.011), which was absent in males. Conclusion Testosterone associates with an increase in sympathetic tone, contributing to adverse cardiac remodeling following MI. Conversely, females maintain sympathetic integrity, independent of sex hormones. Our results suggest a biological advantage of female sex in post MI recovery. Further research is warranted to confirm these findings in humans.
Document Type: Article
Other literature type
File Description: application/pdf; application/application/pdf; ZORA275658.pdf - application/pdf
Language: English
ISSN: 2042-6410
DOI: 10.1186/s13293-024-00673-5
DOI: 10.5167/uzh-275658
DOI: 10.48620/84921
DOI: 10.3929/ethz-b-000719004
Access URL: https://pubmed.ncbi.nlm.nih.gov/39819738
https://doaj.org/article/93b90ea521bf4fb8ba90a5f56d10be7e
https://repository.publisso.de/resource/frl:6519641
http://hdl.handle.net/20.500.11850/719004
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Accession Number: edsair.doi.dedup.....f976cf377e83c110b5b95cf533713f32
Database: OpenAIRE
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