Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus
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| Title: | Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus |
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| Authors: | Marcello Ricardo Paulista Markus, Till Ittermann, Sabine Schipf, Martin Bahls, Matthias Nauck, Henry Völzke, Raul Dias Santos, Annette Peters, Tanja Zeller, Stephan Burkhard Felix, Ramachandran S. Vasan, Barbara Thorand, Elisabeth Steinhagen-Thiessen, Marcus Dörr |
| Source: | Cardiovasc Diabetol Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-11 (2021) Cardiovasc. Diabetol. 20:168 (2021) |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Adult, Male, Cardiovascular mortality, Aged, 80 and over [MeSH], Aged [MeSH], Risk Assessment [MeSH], Type 2 diabetes mellitus, Cardiovascular Diseases/diagnosis [MeSH], Risk Factors [MeSH], Diabetes Mellitus, Type 2/mortality [MeSH], Germany/epidemiology [MeSH], Dyslipidemia, Original Investigation, Male [MeSH], Prevalence [MeSH], Cardiovascular Diseases/mortality [MeSH], Sex Factors [MeSH], Diabetes Mellitus, Type 2/diagnosis [MeSH], Female [MeSH], Lipoprotein(a)/blood [MeSH], Adult [MeSH], Biomarkers/blood [MeSH], Humans [MeSH], Longitudinal Studies [MeSH], Incidence [MeSH], Middle Aged [MeSH], Diabetes Mellitus, Type 2/blood [MeSH], Lipoprotein(a), Time Factors [MeSH], Health Status Disparities [MeSH], Cardiovascular Diseases/blood [MeSH], Prognosis [MeSH], Young Adult [MeSH], Sex-specific, Risk Assessment, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Germany, Prevalence, Diseases of the circulatory (Cardiovascular) system, Humans, Longitudinal Studies, Aged, Aged, 80 and over, 2. Zero hunger, Incidence, Health Status Disparities, Middle Aged, Prognosis, 3. Good health, Diabetes Mellitus, Type 2, Cardiovascular Diseases, RC666-701, Cardiovascular Mortality, Type 2 Diabetes Mellitus, Female, Biomarkers |
| Description: | Background Compared to individuals without type 2 diabetes mellitus, the relative increase in cardiovascular mortality is much higher in women than in men in individuals with type 2 diabetes mellitus. Methods We evaluated data from 7443 individuals (3792 women, 50.9%), aged 20 to 81 years, from two independent population-based investigations, SHIP-0 and MONICA/KORA S3. We analyzed the longitudinal sex-specific associations of lipoprotein(a) with cardiovascular mortality in individuals with and without type 2 diabetes mellitus using Cox regression. Results During a median follow-up of 20.5 years (136,802 person-years), 657 participants (404 men and 253 women) died of cardiovascular causes. Among individuals without type 2 diabetes mellitus, men had a significantly higher risk for cardiovascular mortality compared to women in unadjusted model and after adjustment. On the other hand, in participants with type 2 diabetes mellitus, the risk for cardiovascular mortality was not different between men and women in the unadjusted model and after adjustment for age, body mass index, low-density lipoprotein-cholesterol, fasting status and study sample (SHIP-0, MONICA/KORA S3). Further adjustment for lipoprotein(a) concentrations had no impact on the hazard ratio (HR) for cardiovascular mortality comparing men versus women in individuals without type 2 diabetes mellitus [HR: 1.94; 95% confidence interval (CI) 1.63 to 2.32; p Conclusions Women are described to have a stronger relative increase in cardiovascular mortality than men when comparing individuals with and without type 2 diabetes mellitus. Higher lipoprotein(a) concentrations in women with type 2 diabetes mellitus than in men with type 2 diabetes mellitus might partially explain this finding. |
| Document Type: | Article Conference object Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1475-2840 |
| DOI: | 10.1186/s12933-021-01363-x |
| Access URL: | https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-021-01363-x https://pubmed.ncbi.nlm.nih.gov/34407812 https://doaj.org/article/570503adc5994ccbbf2e7748f481bb3f https://doaj.org/article/570503adc5994ccbbf2e7748f481bb3f https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01363-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375146 https://pubmed.ncbi.nlm.nih.gov/34407812/ https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=62830 https://repository.publisso.de/resource/frl:6462943 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....f1af7d9ca32c48a5b17fba5ce4bfab67 |
| Database: | OpenAIRE |
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