Systematic assessment of early brain injury severity at admission with aneurysmal subarachnoid hemorrhage
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| Názov: | Systematic assessment of early brain injury severity at admission with aneurysmal subarachnoid hemorrhage |
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| Autori: | Sheri Tuzi, Beate Kranawetter, Dorothee Mielke, Veit Rohde, Vesna Malinova |
| Prispievatelia: | Tuzi, Sheri, Kranawetter, Beate, Mielke, Dorothee, Rohde, Veit, Malinova, Vesna |
| Zdroj: | Neurosurg Rev |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2023. |
| Rok vydania: | 2023 |
| Predmety: | Male, Adult, ddc:610, Decompressive Craniectomy, Research, Brain Edema, Subarachnoid Hemorrhage, Middle Aged, Severity of Illness Index, Brain Edema/diagnostic imaging [MeSH], Brain Edema/etiology [MeSH], Female [MeSH], Brain Injuries/complications [MeSH], Aged [MeSH], Adult [MeSH], Early brain injury, Humans [MeSH], Severity of Illness Index [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Subarachnoid Hemorrhage/complications [MeSH], Brain Ischemia/complications [MeSH], Male [MeSH], Brain imaging, Subarachnoid Hemorrhage/surgery [MeSH], Subarachnoid hemorrhage, Decompressive Craniectomy/methods [MeSH], Brain Ischemia, Brain Injuries, Humans, Female, Aged, Retrospective Studies |
| Popis: | Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) has been increasingly recognized as a risk factor for delayed cerebral ischemia (DCI). While several clinical and radiological EBI biomarkers have been identified, no tool for systematic assessment of EBI severity has been established so far. This study aimed to develop an EBI grading system based on clinical signs and neuroimaging for estimation of EBI severity at admission. This is a retrospective observational study assessing imaging parameters (intracranial blood amount, global cerebral edema (GCE)), and clinical signs (persistent loss of consciousness [LOC]) representative for EBI. The intracranial blood amount was semi-quantitatively assessed. One point was added for GCE and LOC, respectively. All points were summed up resulting in an EBI grading ranging from 1 to 5. The estimated EBI severity was correlated with progressive GCE requiring decompressive hemicraniectomy (DHC), DCI-associated infarction, and outcome according to the modified Rankin scale (mRS) at 3-month-follow up. A consecutive cohort including 324 aSAH-patients with a mean age of 55.9 years, was analyzed. The probability of developing progressive GCE was 9% for EBI grade 1, 28% for EBI grade 2, 43% for EBI grade 3, 61% for EBI grade 4, and 89% for EBI grade 5. The EBI grading correlated significantly with the need for DHC (r = 0.25, p r = 0.30, p r = 0.31, p |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1437-2320 |
| DOI: | 10.1007/s10143-024-03081-w |
| DOI: | 10.1101/2023.10.17.23297185 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39514015 https://resolver.sub.uni-goettingen.de/purl?gro-2/146901 https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/119366 https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1193664 https://doi.org/10.1007/s10143-024-03081-w https://opus.bibliothek.uni-augsburg.de/opus4/files/119366/s10143-024-03081-w.pdf https://repository.publisso.de/resource/frl:6512378 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....e93ea357ff8fc8801a05e615e0cfae1d |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) has been increasingly recognized as a risk factor for delayed cerebral ischemia (DCI). While several clinical and radiological EBI biomarkers have been identified, no tool for systematic assessment of EBI severity has been established so far. This study aimed to develop an EBI grading system based on clinical signs and neuroimaging for estimation of EBI severity at admission. This is a retrospective observational study assessing imaging parameters (intracranial blood amount, global cerebral edema (GCE)), and clinical signs (persistent loss of consciousness [LOC]) representative for EBI. The intracranial blood amount was semi-quantitatively assessed. One point was added for GCE and LOC, respectively. All points were summed up resulting in an EBI grading ranging from 1 to 5. The estimated EBI severity was correlated with progressive GCE requiring decompressive hemicraniectomy (DHC), DCI-associated infarction, and outcome according to the modified Rankin scale (mRS) at 3-month-follow up. A consecutive cohort including 324 aSAH-patients with a mean age of 55.9 years, was analyzed. The probability of developing progressive GCE was 9% for EBI grade 1, 28% for EBI grade 2, 43% for EBI grade 3, 61% for EBI grade 4, and 89% for EBI grade 5. The EBI grading correlated significantly with the need for DHC (r = 0.25, p r = 0.30, p r = 0.31, p |
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| ISSN: | 14372320 |
| DOI: | 10.1007/s10143-024-03081-w |