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Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway

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Titel: Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway
Autoren: De Bock, Marijke, Wang, Nan, Bol, Mélissa, Decrock, Elke, Ponsaerts, Raf, Bultynck, Geert, Dupont, Geneviève, Leybaert, Luc
Quelle: The Journal of biological chemistry, 287 (15
Verlagsinformationen: Elsevier BV, 2012.
Publikationsjahr: 2012
Schlagwörter: Calcium Channel Blockers -- pharmacology, 0301 basic medicine, Cytoplasm, Inositol 1,4,5-Trisphosphate -- metabolism, Peptides -- pharmacology, Inositol 1,4,5-Trisphosphate, Bradykinin, Connexins, Cell Line, 03 medical and health sciences, Adenosine Triphosphate, Dogs, Chimie, Animals, Humans, Calcium Signaling, Fluoresceins -- metabolism, Recombinant Proteins -- metabolism, 0303 health sciences, Calcium Channels -- metabolism, Carbenoxolone -- pharmacology, Connexins -- metabolism, Oligopeptides -- pharmacology, Cytochromes c, Calcium Channel Blockers, Fluoresceins, Rats, Connexin 43 -- genetics -- metabolism, Cytoplasm -- metabolism, Bradykinin -- pharmacology, Adenosine Triphosphate -- metabolism -- pharmacology, Connexin 43, Gene Knockdown Techniques, Cytochromes c -- metabolism -- physiology, Carbenoxolone, Calcium -- metabolism, RNA Interference, Calcium, Calcium Channels, Peptides, Oligopeptides
Beschreibung: Many cellular functions are driven by changes in the intracellular Ca(2+) concentration ([Ca(2+)](i)) that are highly organized in time and space. Ca(2+) oscillations are particularly important in this respect and are based on positive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs). Connexin hemichannels are Ca(2+)-permeable plasma membrane channels that are also controlled by [Ca(2+)](i). We aimed to investigate how hemichannels may contribute to Ca(2+) oscillations. Madin-Darby canine kidney cells expressing connexin-32 (Cx32) and Cx43 were exposed to bradykinin (BK) or ATP to induce Ca(2+) oscillations. BK-induced oscillations were rapidly (minutes) and reversibly inhibited by the connexin-mimetic peptides (32)Gap27/(43)Gap26, whereas ATP-induced oscillations were unaffected. Furthermore, these peptides inhibited the BK-triggered release of calcein, a hemichannel-permeable dye. BK-induced oscillations, but not those induced by ATP, were dependent on extracellular Ca(2+). Alleviating the negative feedback of [Ca(2+)](i) on InsP(3)Rs using cytochrome c inhibited BK- and ATP-induced oscillations. Cx32 and Cx43 hemichannels are activated by
Publikationsart: Article
Dateibeschreibung: 2 full-text file(s): application/pdf; application/pdf
Sprache: English
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.299610
Zugangs-URL: http://www.jbc.org/content/287/15/12250.full.pdf
https://pubmed.ncbi.nlm.nih.gov/22351781
https://pubmed.ncbi.nlm.nih.gov/22351781/
https://europepmc.org/articles/PMC3320976
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/146309/Details
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320976/
https://www.sciencedirect.com/science/article/pii/S0021925820531542
https://www.jbc.org/article/S0021-9258(20)53154-2/fulltext
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/146309
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....e7f1910a94e056b0e3a572bdcc2f5030
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  Data: Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway
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  Data: <searchLink fieldCode="AR" term="%22De+Bock%2C+Marijke%22">De Bock, Marijke</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Nan%22">Wang, Nan</searchLink><br /><searchLink fieldCode="AR" term="%22Bol%2C+Mélissa%22">Bol, Mélissa</searchLink><br /><searchLink fieldCode="AR" term="%22Decrock%2C+Elke%22">Decrock, Elke</searchLink><br /><searchLink fieldCode="AR" term="%22Ponsaerts%2C+Raf%22">Ponsaerts, Raf</searchLink><br /><searchLink fieldCode="AR" term="%22Bultynck%2C+Geert%22">Bultynck, Geert</searchLink><br /><searchLink fieldCode="AR" term="%22Dupont%2C+Geneviève%22">Dupont, Geneviève</searchLink><br /><searchLink fieldCode="AR" term="%22Leybaert%2C+Luc%22">Leybaert, Luc</searchLink>
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  Data: The Journal of biological chemistry, 287 (15
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  Data: Elsevier BV, 2012.
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  Data: <searchLink fieldCode="DE" term="%22Calcium+Channel+Blockers+--+pharmacology%22">Calcium Channel Blockers -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%220301+basic+medicine%22">0301 basic medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoplasm%22">Cytoplasm</searchLink><br /><searchLink fieldCode="DE" term="%22Inositol+1%2C4%2C5-Trisphosphate+--+metabolism%22">Inositol 1,4,5-Trisphosphate -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Peptides+--+pharmacology%22">Peptides -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Inositol+1%2C4%2C5-Trisphosphate%22">Inositol 1,4,5-Trisphosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Bradykinin%22">Bradykinin</searchLink><br /><searchLink fieldCode="DE" term="%22Connexins%22">Connexins</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Line%22">Cell Line</searchLink><br /><searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Adenosine+Triphosphate%22">Adenosine Triphosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Dogs%22">Dogs</searchLink><br /><searchLink fieldCode="DE" term="%22Chimie%22">Chimie</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+Signaling%22">Calcium Signaling</searchLink><br /><searchLink fieldCode="DE" term="%22Fluoresceins+--+metabolism%22">Fluoresceins -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Recombinant+Proteins+--+metabolism%22">Recombinant Proteins -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%220303+health+sciences%22">0303 health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+Channels+--+metabolism%22">Calcium Channels -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Carbenoxolone+--+pharmacology%22">Carbenoxolone -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Connexins+--+metabolism%22">Connexins -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Oligopeptides+--+pharmacology%22">Oligopeptides -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Cytochromes+c%22">Cytochromes c</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+Channel+Blockers%22">Calcium Channel Blockers</searchLink><br /><searchLink fieldCode="DE" term="%22Fluoresceins%22">Fluoresceins</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Connexin+43+--+genetics+--+metabolism%22">Connexin 43 -- genetics -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoplasm+--+metabolism%22">Cytoplasm -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Bradykinin+--+pharmacology%22">Bradykinin -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Adenosine+Triphosphate+--+metabolism+--+pharmacology%22">Adenosine Triphosphate -- metabolism -- pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Connexin+43%22">Connexin 43</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+Knockdown+Techniques%22">Gene Knockdown Techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Cytochromes+c+--+metabolism+--+physiology%22">Cytochromes c -- metabolism -- physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Carbenoxolone%22">Carbenoxolone</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+--+metabolism%22">Calcium -- metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+Interference%22">RNA Interference</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium%22">Calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+Channels%22">Calcium Channels</searchLink><br /><searchLink fieldCode="DE" term="%22Peptides%22">Peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Oligopeptides%22">Oligopeptides</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Many cellular functions are driven by changes in the intracellular Ca(2+) concentration ([Ca(2+)](i)) that are highly organized in time and space. Ca(2+) oscillations are particularly important in this respect and are based on positive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs). Connexin hemichannels are Ca(2+)-permeable plasma membrane channels that are also controlled by [Ca(2+)](i). We aimed to investigate how hemichannels may contribute to Ca(2+) oscillations. Madin-Darby canine kidney cells expressing connexin-32 (Cx32) and Cx43 were exposed to bradykinin (BK) or ATP to induce Ca(2+) oscillations. BK-induced oscillations were rapidly (minutes) and reversibly inhibited by the connexin-mimetic peptides (32)Gap27/(43)Gap26, whereas ATP-induced oscillations were unaffected. Furthermore, these peptides inhibited the BK-triggered release of calcein, a hemichannel-permeable dye. BK-induced oscillations, but not those induced by ATP, were dependent on extracellular Ca(2+). Alleviating the negative feedback of [Ca(2+)](i) on InsP(3)Rs using cytochrome c inhibited BK- and ATP-induced oscillations. Cx32 and Cx43 hemichannels are activated by
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  Data: 10.1074/jbc.m111.299610
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      – Type: doi
        Value: 10.1074/jbc.m111.299610
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 12250
    Subjects:
      – SubjectFull: Calcium Channel Blockers -- pharmacology
        Type: general
      – SubjectFull: 0301 basic medicine
        Type: general
      – SubjectFull: Cytoplasm
        Type: general
      – SubjectFull: Inositol 1,4,5-Trisphosphate -- metabolism
        Type: general
      – SubjectFull: Peptides -- pharmacology
        Type: general
      – SubjectFull: Inositol 1,4,5-Trisphosphate
        Type: general
      – SubjectFull: Bradykinin
        Type: general
      – SubjectFull: Connexins
        Type: general
      – SubjectFull: Cell Line
        Type: general
      – SubjectFull: 03 medical and health sciences
        Type: general
      – SubjectFull: Adenosine Triphosphate
        Type: general
      – SubjectFull: Dogs
        Type: general
      – SubjectFull: Chimie
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Calcium Signaling
        Type: general
      – SubjectFull: Fluoresceins -- metabolism
        Type: general
      – SubjectFull: Recombinant Proteins -- metabolism
        Type: general
      – SubjectFull: 0303 health sciences
        Type: general
      – SubjectFull: Calcium Channels -- metabolism
        Type: general
      – SubjectFull: Carbenoxolone -- pharmacology
        Type: general
      – SubjectFull: Connexins -- metabolism
        Type: general
      – SubjectFull: Oligopeptides -- pharmacology
        Type: general
      – SubjectFull: Cytochromes c
        Type: general
      – SubjectFull: Calcium Channel Blockers
        Type: general
      – SubjectFull: Fluoresceins
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Connexin 43 -- genetics -- metabolism
        Type: general
      – SubjectFull: Cytoplasm -- metabolism
        Type: general
      – SubjectFull: Bradykinin -- pharmacology
        Type: general
      – SubjectFull: Adenosine Triphosphate -- metabolism -- pharmacology
        Type: general
      – SubjectFull: Connexin 43
        Type: general
      – SubjectFull: Gene Knockdown Techniques
        Type: general
      – SubjectFull: Cytochromes c -- metabolism -- physiology
        Type: general
      – SubjectFull: Carbenoxolone
        Type: general
      – SubjectFull: Calcium -- metabolism
        Type: general
      – SubjectFull: RNA Interference
        Type: general
      – SubjectFull: Calcium
        Type: general
      – SubjectFull: Calcium Channels
        Type: general
      – SubjectFull: Peptides
        Type: general
      – SubjectFull: Oligopeptides
        Type: general
    Titles:
      – TitleFull: Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway
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            NameFull: De Bock, Marijke
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              M: 04
              Type: published
              Y: 2012
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              Value: 287
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            – TitleFull: Journal of Biological Chemistry
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