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The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression

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Titel: The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression
Autoren: Matea Nikolac Perkovic, Martin Gredicak, Marina Sagud, Gordana Nedic Erjavec, Suzana Uzun, Nela Pivac
Quelle: Expert Review of Molecular Diagnostics. 23:283-296
Verlagsinformationen: Informa UK Limited, 2023.
Publikationsjahr: 2023
Schlagwörter: Antidepressive Agents / therapeutic use, Depressive Disorder, Major / diagnosis, Depressive Disorder, Major, Genotype, Depression, Brain-Derived Neurotrophic Factor / genetics, Brain-Derived Neurotrophic Factor, Depression / etiology, Polymorphism, Single Nucleotide, Depression / drug therapy, Antidepressive Agents, 3. Good health, Depressive Disorder, Major / drug therapy, BDNF, BDNF Val66Met, antidepressants, depression, treatment response, Depressive Disorder, Major / genetics, Humans, Brain-Derived Neurotrophic Factor / therapeutic use, Depression / diagnosis
Beschreibung: Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) polymorphism, and major depressive disorders, referred as depression, and the association between BDNF levels and/or BDNF Val66Met with the treatment response in depression is presented.This mini review focuses on the changes in the peripheral BDNF levels in blood (serum, plasma, platelets) in patients with depression before or after treatment with antidepressant drugs or different therapeutic strategies. In addition, this review describes the recent data on the possible association between different antidepressants/therapeutic strategies and the particular BDNF Val66Met genotypes, evaluating the risk alleles associated with the response in patients with depression.BDNF has an important role in the pathophysiology and treatment response in depression. Most data reveal that peripheral BDNF levels are lower before than after antidepressant treatment and might be used as potential biomarkers of therapeutic response. Novel therapeutic strategies should target restoring/increasing BDNF levels.
Publikationsart: Article
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1744-8352
1473-7159
DOI: 10.1080/14737159.2023.2200937
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37038358
https://urn.nsk.hr/urn:nbn:hr:105:267765
https://doi.org/10.1080/14737159.2023.2200937
Rights: CC BY NC
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  Data: The association of brain-derived neurotrophic factor with the diagnosis and treatment response in depression
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  Data: <searchLink fieldCode="AR" term="%22Matea+Nikolac+Perkovic%22">Matea Nikolac Perkovic</searchLink><br /><searchLink fieldCode="AR" term="%22Martin+Gredicak%22">Martin Gredicak</searchLink><br /><searchLink fieldCode="AR" term="%22Marina+Sagud%22">Marina Sagud</searchLink><br /><searchLink fieldCode="AR" term="%22Gordana+Nedic+Erjavec%22">Gordana Nedic Erjavec</searchLink><br /><searchLink fieldCode="AR" term="%22Suzana+Uzun%22">Suzana Uzun</searchLink><br /><searchLink fieldCode="AR" term="%22Nela+Pivac%22">Nela Pivac</searchLink>
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  Data: <i>Expert Review of Molecular Diagnostics</i>. 23:283-296
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  Data: Informa UK Limited, 2023.
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  Data: 2023
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  Data: <searchLink fieldCode="DE" term="%22Antidepressive+Agents+%2F+therapeutic+use%22">Antidepressive Agents / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Depressive+Disorder%2C+Major+%2F+diagnosis%22">Depressive Disorder, Major / diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Depressive+Disorder%2C+Major%22">Depressive Disorder, Major</searchLink><br /><searchLink fieldCode="DE" term="%22Genotype%22">Genotype</searchLink><br /><searchLink fieldCode="DE" term="%22Depression%22">Depression</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-Derived+Neurotrophic+Factor+%2F+genetics%22">Brain-Derived Neurotrophic Factor / genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-Derived+Neurotrophic+Factor%22">Brain-Derived Neurotrophic Factor</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+%2F+etiology%22">Depression / etiology</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%2C+Single+Nucleotide%22">Polymorphism, Single Nucleotide</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+%2F+drug+therapy%22">Depression / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressive+Agents%22">Antidepressive Agents</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22Depressive+Disorder%2C+Major+%2F+drug+therapy%22">Depressive Disorder, Major / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22BDNF%22">BDNF</searchLink><br /><searchLink fieldCode="DE" term="%22BDNF+Val66Met%22">BDNF Val66Met</searchLink><br /><searchLink fieldCode="DE" term="%22antidepressants%22">antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22depression%22">depression</searchLink><br /><searchLink fieldCode="DE" term="%22treatment+response%22">treatment response</searchLink><br /><searchLink fieldCode="DE" term="%22Depressive+Disorder%2C+Major+%2F+genetics%22">Depressive Disorder, Major / genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-Derived+Neurotrophic+Factor+%2F+therapeutic+use%22">Brain-Derived Neurotrophic Factor / therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+%2F+diagnosis%22">Depression / diagnosis</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Recent evidence from the studies evaluating the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) polymorphism, and major depressive disorders, referred as depression, and the association between BDNF levels and/or BDNF Val66Met with the treatment response in depression is presented.This mini review focuses on the changes in the peripheral BDNF levels in blood (serum, plasma, platelets) in patients with depression before or after treatment with antidepressant drugs or different therapeutic strategies. In addition, this review describes the recent data on the possible association between different antidepressants/therapeutic strategies and the particular BDNF Val66Met genotypes, evaluating the risk alleles associated with the response in patients with depression.BDNF has an important role in the pathophysiology and treatment response in depression. Most data reveal that peripheral BDNF levels are lower before than after antidepressant treatment and might be used as potential biomarkers of therapeutic response. Novel therapeutic strategies should target restoring/increasing BDNF levels.
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        Value: 10.1080/14737159.2023.2200937
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      – Text: English
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        PageCount: 14
        StartPage: 283
    Subjects:
      – SubjectFull: Antidepressive Agents / therapeutic use
        Type: general
      – SubjectFull: Depressive Disorder, Major / diagnosis
        Type: general
      – SubjectFull: Depressive Disorder, Major
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      – SubjectFull: BDNF
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      – SubjectFull: BDNF Val66Met
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