Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction
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| Názov: | Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction |
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| Autori: | Daisuke Imai, Takashi Maeda, Huanlin Wang, Kensaku Sanefuji, Hiroto Kayashima, Shohei Yoshiya, Kazuki Takeishi, Shinji Itoh, Noboru Harada, Toru Ikegami, Tomoharu Yoshizumi, Masaki Mori |
| Zdroj: | Ann Gastroenterol Surg Annals of Gastroenterological Surgery, Vol 3, Iss 5, Pp 515-522 (2019) |
| Informácie o vydavateľovi: | Wiley, 2019. |
| Rok vydania: | 2019 |
| Predmety: | 0301 basic medicine, 0303 health sciences, RD1-811, RC799-869, Original Articles, Diseases of the digestive system. Gastroenterology, 3. Good health, Pringle maneuver, 03 medical and health sciences, renal dysfunction, liver resection, Mac‐2 binding protein glycosylation isomer, post‐hepatectomy liver failure, Surgery |
| Popis: | BackgroundMac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis.MethodsWe retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2BPGi ratio” (=M2BPGiafter operation/M2BPGibefore operation), and analyzed factors that influenced the ΔM2BPGi ratio.ResultsThe median value of the ΔM2BPGi ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2BPGi ratio. The mean values of the ΔM2BPGi ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test (P = 0.022).ConclusionsTotal Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 2475-0328 |
| DOI: | 10.1002/ags3.12271 |
| Prístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ags3.12271 https://pubmed.ncbi.nlm.nih.gov/31549011 https://doaj.org/article/6bdf2ef3407940cb9388c213238130da https://kyushu-u.pure.elsevier.com/en/publications/elevation-of-mac-2-binding-protein-glycosylation-isomer-after-hep https://onlinelibrary.wiley.com/doi/pdf/10.1002/ags3.12271 https://pubmed.ncbi.nlm.nih.gov/31549011/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749955/ https://onlinelibrary.wiley.com/doi/full/10.1002/ags3.12271 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....e19ca3e5e927caa7c94a1d33dceb4195 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | BackgroundMac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis.MethodsWe retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2BPGi ratio” (=M2BPGiafter operation/M2BPGibefore operation), and analyzed factors that influenced the ΔM2BPGi ratio.ResultsThe median value of the ΔM2BPGi ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2BPGi ratio. The mean values of the ΔM2BPGi ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test (P = 0.022).ConclusionsTotal Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis. |
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| ISSN: | 24750328 |
| DOI: | 10.1002/ags3.12271 |