The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels
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| Názov: | The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels |
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| Autori: | Sira Karvinen, Emilia Lähteenmäki, Bettina Hutz, Hanna‐Kaarina Juppi, Jari E. Karppinen, Anna Kankaanpää, Maarit Lehti, Eija K. Laakkonen |
| Zdroj: | Physiol Rep Physiological Reports, Vol 13, Iss 9, Pp n/a-n/a (2025) |
| Informácie o vydavateľovi: | Wiley, 2025. |
| Rok vydania: | 2025 |
| Predmety: | Adult, estradioli, Fyysinen aktiivisuus eliniän aikana, vaihdevuodet, kestävyysharjoittelu, Physiology, mitokondriot, menopause, Leukocyte Count, Oxygen Consumption, Liikuntafysiologia, Exercise Physiology, Hyvinvoinnin tutkimuksen yhteisö, QP1-981, Humans, Physical activity through life span, Sports and Exercise Medicine, Exercise, School of Wellbeing, Gerontologia ja kansanterveys, valkosolut, Estradiol, Liikuntalääketiede, Middle Aged, mitochondria, immuunivaste, sydän- ja verisuonitaudit, Leukocytes, Mononuclear, Exercise Test, Original Article, Female, white blood cell, Energy Metabolism, Gerontology and Public Health |
| Popis: | Decrease in the systemic estradiol (E2) levels caused by menopause has been associated with an increased risk for cardiovascular disease. We have previously shown that E2 level is associated with the systemic response to an acute bout of endurance exercise. However, the association of systemic E2 level with peripheral blood mononuclear cell (PBMC) bioenergetic function has not been investigated. We examined the associations of systemic E2 level (HIGH and LOW E2 groups) on WBC count and PBMC bioenergetic function before and after an acute bout of endurance exercise (time points PRE, POST and 1 h POST exercise). Exercise stimulus was a maximal incremental bicycle ergometer test. We show that an acute bout of exercise induced a transient increase in WBC count in both HIGH and LOW E2 study groups (p p p |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf; fulltext |
| Jazyk: | English |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.70296 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/40312145 https://doaj.org/article/ce79e0aff06c44c5a1b2aec8ed0d552e http://urn.fi/URN:NBN:fi:jyu-202505063862 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....dca6c4b3f532eaf9c60f0716bc20f33e |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Decrease in the systemic estradiol (E2) levels caused by menopause has been associated with an increased risk for cardiovascular disease. We have previously shown that E2 level is associated with the systemic response to an acute bout of endurance exercise. However, the association of systemic E2 level with peripheral blood mononuclear cell (PBMC) bioenergetic function has not been investigated. We examined the associations of systemic E2 level (HIGH and LOW E2 groups) on WBC count and PBMC bioenergetic function before and after an acute bout of endurance exercise (time points PRE, POST and 1 h POST exercise). Exercise stimulus was a maximal incremental bicycle ergometer test. We show that an acute bout of exercise induced a transient increase in WBC count in both HIGH and LOW E2 study groups (p p p |
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| ISSN: | 2051817X |
| DOI: | 10.14814/phy2.70296 |