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Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort

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Název: Associations of C-reactive protein with depressive symptoms over time after mild to moderate ischemic stroke in the PROSCIS-B cohort
Autoři: Viktoria L. K. Schaeff, Pia S. Sperber, Sophie K. Piper, Naomi K. Giesers, Karen Gertz, Peter U. Heuschmann, Matthias Endres, Thomas G. Liman
Zdroj: J Neurol
Journal of neurology 271(2), 909-917 (2024). doi:10.1007/s00415-023-12038-w
Informace o vydavateli: Springer Science and Business Media LLC, 2023.
Rok vydání: 2023
Témata: Male, etiology [Depression], metabolism [C-Reactive Protein], hs-crp, Risk Factors, ischemic stroke, Humans, complications [Stroke], ddc:610, Prospective Studies, Aged, Ischemic Stroke, Inflammation, Aged, 80 and over, Ischemic stroke, Original Communication, Depression, Middle Aged, diagnosis [Stroke], 3. Good health, Stroke, C-Reactive Protein, inflammation, depression, Hs-CRP, Integrative Biomedicine [Topic 3], Female, Female [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Humans [MeSH], Prospective Studies [MeSH], Middle Aged [MeSH], Risk Factors [MeSH], Stroke/complications [MeSH], C-Reactive Protein/metabolism [MeSH], Ischemic Stroke [MeSH], Stroke/diagnosis [MeSH], Male [MeSH], Depression/etiology [MeSH], Biomarkers [MeSH], Function and Dysfunction of the Nervous System, Biomarkers
Popis: Background and purpose C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients. Methods Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex. Results We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1–4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D ≥ 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (β = 1.28; (95% CI 0.22–2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (β = 2.33; (95% CI 0.71–3.95)). Conclusion In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex. Study registration https://clinicaltrials.gov; Unique identifier: NCT01363856.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
Jazyk: English
ISSN: 1432-1459
0340-5354
DOI: 10.1007/s00415-023-12038-w
DOI: 10.17169/refubium-49529
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37848651
https://edoc.mdc-berlin.de/id/eprint/23802/5/23802suppl.docx
https://repository.publisso.de/resource/frl:6523652
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....d5e0522be29dc9065b4d76c9062abddf
Databáze: OpenAIRE
Popis
Abstrakt:Background and purpose C-reactive protein serves as a marker of inflammation and is linked to depression in the general population. We aimed to assess whether elevated baseline levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressive symptoms over time in a prospective cohort of mild-to-moderate first-ever ischemic stroke patients. Methods Data were obtained from the Prospective Cohort with Incident Stroke Berlin (NCT01363856). Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) at three annual follow-up points. We assessed the association of elevated levels of hs-CRP with CES-D scores over time via linear mixed models. In a subgroup analysis, we explored an interaction effect with sex. Results We included 585 ischemic stroke patients with baseline data on CRP levels. The mean age was 67 (13 SD), 39% (n = 226) were female, and the median National Institutes of Health Stroke Scale (NIHSS) was 3 (IQR 1–4). Twenty percent of survivors showed evidence for depressive symptoms one year after stroke with CES-D ≥ 16, 21% at year two, and 17% at year three. Higher log-transformed baseline hs-CRP levels were associated with higher CES-D Scores over time in the adjusted linear mixed model (β = 1.28; (95% CI 0.22–2.34)). The subgroup analysis revealed an interaction effect of hs-CRP on depressive symptoms in women (β = 2.33; (95% CI 0.71–3.95)). Conclusion In our cohort with mild-to-moderate first-ever ischemic stroke patients, hs-CRP levels were associated with more depressive symptoms over time, with an interaction effect for the female sex. Study registration https://clinicaltrials.gov; Unique identifier: NCT01363856.
ISSN:14321459
03405354
DOI:10.1007/s00415-023-12038-w