A case series of Mediterranean spotted fever and murine typhus with neurological manifestations
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| Title: | A case series of Mediterranean spotted fever and murine typhus with neurological manifestations |
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| Authors: | Fatma Hammami, Makram Koubaa, Amal Chakroun, Khaoula Rekik, Sonda Mezghani, Adnane Hammami, Chakib Marrakchi, Fatma Smaoui, Mounir Ben Jemaa |
| Source: | Journal of Vector Borne Diseases, Vol 61, Iss 3, Pp 489-494 (2024) |
| Publisher Information: | Medknow, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, Tunisia, Adolescent, rickettsial infection, meningitis, Typhus, Endemic Flea-Borne, Infectious and parasitic diseases, RC109-216, neurological manifestation, Middle Aged, Boutonneuse Fever, mediterranean spotted fever murine typhus, Anti-Bacterial Agents, Young Adult, Humans, Female, Child, Retrospective Studies, Aged |
| Description: | Background & objectives: Severe cases with neurological manifestations of rickettsiosis have been reported. We aimed to identify the epidemiological, clinical and laboratory features of central nervous system rickettsial infections and to describe the treatment. Methods: We carried out a retrospective study that included all patients hospitalized with rickettsiosis in the infectious diseases department of Hedi Chaker University Hospital in Sfax, Tunisia between 1993 and 2018. Results: We identified 47 patients with central nervous system rickettsial infections among 440 patients with rickettsial infections (10.7%). Skin rash (31.9% vs 87.8%; p Interpretation & conclusion: Cardinal clinical features and typical laboratory results including thrombocytopenia were less frequent, and prognosis was more severe in patients with central nervous system rickettsial infections. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 0972-9062 |
| DOI: | 10.4103/0972-9062.383643 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39374494 https://doaj.org/article/5d41a9e73cea42a8bd42035a5792e143 |
| Accession Number: | edsair.doi.dedup.....d1a4ee4eec1fdc0dca3775adb31af46f |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background & objectives: Severe cases with neurological manifestations of rickettsiosis have been reported. We aimed to identify the epidemiological, clinical and laboratory features of central nervous system rickettsial infections and to describe the treatment. Methods: We carried out a retrospective study that included all patients hospitalized with rickettsiosis in the infectious diseases department of Hedi Chaker University Hospital in Sfax, Tunisia between 1993 and 2018. Results: We identified 47 patients with central nervous system rickettsial infections among 440 patients with rickettsial infections (10.7%). Skin rash (31.9% vs 87.8%; p Interpretation & conclusion: Cardinal clinical features and typical laboratory results including thrombocytopenia were less frequent, and prognosis was more severe in patients with central nervous system rickettsial infections. |
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| ISSN: | 09729062 |
| DOI: | 10.4103/0972-9062.383643 |