Regional variation in incidence and prognosis of acute kidney injury
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| Názov: | Regional variation in incidence and prognosis of acute kidney injury |
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| Autori: | Simon Kok Jensen, Thomas Bøjer Rasmussen, Bjarke Hejlskov Jacobsen, Uffe Heide-Jørgensen, Simon Sawhney, Henrik Gammelager, Henrik Birn, Søren Paaske Johnsen, Christian Fynbo Christiansen |
| Zdroj: | Jensen, S K, Rasmussen, T B, Jacobsen, B H, Heide-Jørgensen, U, Sawhney, S, Gammelager, H, Birn, H, Johnsen, S P & Christiansen, C F 2024, 'Regional variation in incidence and prognosis of acute kidney injury', Nephrology, Dialysis, Transplantation, vol. 39, no. 7, gfad267, pp. 1171-1180. https://doi.org/10.1093/ndt/gfad267 Jensen, S K, Rasmussen, T B, Jacobsen, B H, Heide-Jørgensen, U, Sawhney, S, Gammelager, H, Birn, H, Johnsen, S P & Christiansen, C F 2024, 'Regional variation in incidence and prognosis of acute kidney injury', Nephrology Dialysis Transplantation, vol. 39, no. 7, pp. 1171-1180. https://doi.org/10.1093/ndt/gfad267 |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2023. |
| Rok vydania: | 2023 |
| Predmety: | Male, Adult, Aged, 80 and over, Incidence, Denmark, Acute Kidney Injury, Middle Aged, Prognosis, Denmark/epidemiology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, acute kidney injury, Risk Factors, incidence, Humans, Female, prognosis, variation, Renal Insufficiency, Chronic, Renal Insufficiency, Chronic/epidemiology, Acute Kidney Injury/epidemiology, chronic kidney disease, Aged, Follow-Up Studies |
| Popis: | Background Examining regional variation in acute kidney injury (AKI) and associated outcomes may reveal inequalities and possibilities for optimization of the quality of care. Using the Danish medical databases, we examined regional variation in the incidence, follow-up and prognosis of AKI in Denmark. Methods Patients with one or more AKI episodes in 2017 were identified using population-based creatinine measurements covering all Danish residents. Crude and sex-and-age-standardized incidence rates of AKI were estimated using census statistics for each municipality. Adjusted hazard ratios (aHR) of chronic kidney disease (CKD), all-cause death, biochemical follow-up and outpatient contact with a nephrology department after AKI were estimated across geographical regions and categories of municipalities, accounting for differences in demographics, comorbidities, medication use, lifestyle and social factors, and baseline kidney function. Results We identified 63 382 AKI episodes in 58 356 adults in 2017. The regional standardized AKI incidence rates ranged from 12.9 to 14.9 per 1000 person-years. Compared with the Capital Region of Denmark, the aHRs across regions ranged from 1.04 to 1.25 for CKD, from 0.97 to 1.04 for all-cause death, from 1.09 to 1.15 for biochemical follow-up and from 1.08 to 1.49 for outpatient contact with a nephrology department after AKI. Similar variations were found across municipality categories. Conclusions Within the uniform Danish healthcare system, we found modest regional variation in AKI incidence. The mortality after AKI was similar; however, CKD, biochemical follow-up and nephrology follow-up after AKI varied across regions and municipality categories. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfad267 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38140955 https://vbn.aau.dk/da/publications/dee86ddc-d65d-46e0-a444-37691daf453c http://www.scopus.com/inward/record.url?scp=85197089952&partnerID=8YFLogxK https://vbn.aau.dk/ws/files/638229847/Jensen_et_al._2023_._Regional_variation_in_incidence_and_prognosis_of_acute_kidney_injury.pdf https://doi.org/10.1093/ndt/gfad267 https://pure.au.dk/portal/en/publications/91912c1b-e241-482f-bcf1-b67fa0f59a1b http://www.scopus.com/inward/record.url?scp=85197089952&partnerID=8YFLogxK https://doi.org/10.1093/ndt/gfad267 |
| Rights: | OUP Standard Publication Reuse |
| Prístupové číslo: | edsair.doi.dedup.....ca8a0c5c6ac3f261bedc12befe455898 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Background Examining regional variation in acute kidney injury (AKI) and associated outcomes may reveal inequalities and possibilities for optimization of the quality of care. Using the Danish medical databases, we examined regional variation in the incidence, follow-up and prognosis of AKI in Denmark. Methods Patients with one or more AKI episodes in 2017 were identified using population-based creatinine measurements covering all Danish residents. Crude and sex-and-age-standardized incidence rates of AKI were estimated using census statistics for each municipality. Adjusted hazard ratios (aHR) of chronic kidney disease (CKD), all-cause death, biochemical follow-up and outpatient contact with a nephrology department after AKI were estimated across geographical regions and categories of municipalities, accounting for differences in demographics, comorbidities, medication use, lifestyle and social factors, and baseline kidney function. Results We identified 63 382 AKI episodes in 58 356 adults in 2017. The regional standardized AKI incidence rates ranged from 12.9 to 14.9 per 1000 person-years. Compared with the Capital Region of Denmark, the aHRs across regions ranged from 1.04 to 1.25 for CKD, from 0.97 to 1.04 for all-cause death, from 1.09 to 1.15 for biochemical follow-up and from 1.08 to 1.49 for outpatient contact with a nephrology department after AKI. Similar variations were found across municipality categories. Conclusions Within the uniform Danish healthcare system, we found modest regional variation in AKI incidence. The mortality after AKI was similar; however, CKD, biochemical follow-up and nephrology follow-up after AKI varied across regions and municipality categories. |
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| ISSN: | 14602385 09310509 |
| DOI: | 10.1093/ndt/gfad267 |