In EDS ansehen

Association of Right Ventricular Myocardial Blood Flow With Pulmonary Pressures and Outcome in Cardiac Amyloidosis

Gespeichert in:
Bibliographische Detailangaben
Titel: Association of Right Ventricular Myocardial Blood Flow With Pulmonary Pressures and Outcome in Cardiac Amyloidosis
Autoren: Hendrik J. Harms, Tor Clemmensen, Sara Rosengren, Lars Tolbod, Björn Pilebro, Gerhard Wikström, Sven-Olof Granstam, Tanja Kero, Marcelo Di Carli, Steen Hvitfeldt Poulsen, Jens Sorensen
Quelle: Harms, H J, Clemmensen, T, Rosengren, S, Tolbod, L, Pilebro, B, Wikström, G, Granstam, S-O, Kero, T, Di Carli, M, Poulsen, S H & Sorensen, J 2023, 'Association of Right Ventricular Myocardial Blood Flow With pulmonary Pressures and Outcome in Cardiac Amyloidosis', JACC: Cardiovascular Imaging, vol. 16, no. 9, pp. 1193-1204. https://doi.org/10.1016/j.jcmg.2023.01.024
Verlagsinformationen: Elsevier BV, 2023.
Publikationsjahr: 2023
Schlagwörter: Heart Failure, positron emission tomography, Ventricular Dysfunction, Right, Heart Ventricles, cardiac amyloidosis, Amyloidosis, right ventricle, Heart Ventricles/diagnostic imaging, myocardial blood flow, 3. Good health, Predictive Value of Tests, Echocardiography, pulmonary hypertension, Humans, Tomography, X-Ray Computed, Ventricular Dysfunction, Right/diagnostic imaging
Beschreibung: Cardiac amyloidosis (CA) is a restrictive and infiltrative cardiomyopathy, characterized by increased biventricular filling pressures and low output. Symptoms are predominantly of right heart origin. The role of right ventricular (RV) myocardial blood flow (MBF) in CA has not been studied.This study aimed to first associate RV MBF measured by using positron emission tomography (PET) with reference standards of RV pressures and then to explore its prognostic value in CA.Cardiac PET was performed at rest in 52 patients with CA and 9 healthy control subjects. MBF was quantified from the right and left ventricles by using 11C-acetate, 15O-water, or both (n = 25). RV pressure was measured invasively or by echocardiography. Associations between biventricular MBF toward symptoms, RV function, and outcome (death or acute heart failure) were studied in patients with CA.MBF of the right ventricle (MBFRV) and the ratio of MBFRV and MBF of the left ventricle (MBFRV/LV) for the 2 tracers were significantly correlated (r > 0.92). MBFRV was directly correlated with RV systolic pressures with both tracers (P ≤ 0.005). MBFLV was inversely correlated with wall thickness (P < 0.0001). MBFRV/LV was significantly associated with N-terminal pro-B-type natriuretic peptide levels, NYHA functional class, RV pressures, and RV systolic function (all; P < 0.001). Twenty-six cardiac events (25 deaths) occurred during follow-up (median 44 months). MBFRV/LV higher than 56% was associated with a diagnosis of pulmonary hypertension (AUC: 0.96 [95% CI: 0.91-1.00]; P
Publikationsart: Article
Sprache: English
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2023.01.024
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37052560
Rights: Elsevier Non-Commercial
Dokumentencode: edsair.doi.dedup.....c443c54c8bf64b2e9dd708b6be14e08c
Datenbank: OpenAIRE
Beschreibung
Abstract:Cardiac amyloidosis (CA) is a restrictive and infiltrative cardiomyopathy, characterized by increased biventricular filling pressures and low output. Symptoms are predominantly of right heart origin. The role of right ventricular (RV) myocardial blood flow (MBF) in CA has not been studied.This study aimed to first associate RV MBF measured by using positron emission tomography (PET) with reference standards of RV pressures and then to explore its prognostic value in CA.Cardiac PET was performed at rest in 52 patients with CA and 9 healthy control subjects. MBF was quantified from the right and left ventricles by using 11C-acetate, 15O-water, or both (n = 25). RV pressure was measured invasively or by echocardiography. Associations between biventricular MBF toward symptoms, RV function, and outcome (death or acute heart failure) were studied in patients with CA.MBF of the right ventricle (MBFRV) and the ratio of MBFRV and MBF of the left ventricle (MBFRV/LV) for the 2 tracers were significantly correlated (r > 0.92). MBFRV was directly correlated with RV systolic pressures with both tracers (P ≤ 0.005). MBFLV was inversely correlated with wall thickness (P < 0.0001). MBFRV/LV was significantly associated with N-terminal pro-B-type natriuretic peptide levels, NYHA functional class, RV pressures, and RV systolic function (all; P < 0.001). Twenty-six cardiac events (25 deaths) occurred during follow-up (median 44 months). MBFRV/LV higher than 56% was associated with a diagnosis of pulmonary hypertension (AUC: 0.96 [95% CI: 0.91-1.00]; P
ISSN:1936878X
DOI:10.1016/j.jcmg.2023.01.024