Function-guided differences of arcuate fascicle and inferior fronto-occipital fascicle tractography as diagnostic indicators for surgical risk stratification
Gespeichert in:
| Titel: | Function-guided differences of arcuate fascicle and inferior fronto-occipital fascicle tractography as diagnostic indicators for surgical risk stratification |
|---|---|
| Autoren: | Kram, Leonie, Schroeder, Axel, Meyer, Bernhard, Krieg, Sandro M., Ille, Sebastian |
| Quelle: | Brain Struct Funct |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Male, Adult, Brain Mapping, Brain Neoplasms, 05 social sciences, Glioma, Middle Aged, Transcranial Magnetic Stimulation, Risk Assessment, White Matter, ddc, Frontal Lobe, 03 medical and health sciences, Diffusion Tensor Imaging, 0302 clinical medicine, Neural Pathways, Aphasia, Humans, Original Article, Female, 0501 psychology and cognitive sciences, Glioma/surgery [MeSH], Aged [MeSH], Risk Assessment [MeSH], Brain Neoplasms/surgery [MeSH], Glioma/diagnostic imaging [MeSH], Navigated transcranial magnetic stimulation, Glioma/pathology [MeSH], Male [MeSH], White Matter/diagnostic imaging [MeSH], Aphasia risk stratification, Brain Mapping/methods [MeSH], Diffusion tensor imaging-based tractography, Female [MeSH], Transcranial Magnetic Stimulation [MeSH], Adult [MeSH], Aphasia/diagnostic imaging [MeSH], Language [MeSH], Humans [MeSH], Diffusion Tensor Imaging/methods [MeSH], Frontal Lobe/diagnostic imaging [MeSH], Middle Aged [MeSH], Neural Pathways/diagnostic imaging [MeSH], Aphasia/etiology [MeSH], Brain tumor, Language mapping, Brain Neoplasms/diagnostic imaging [MeSH], Aged, Language |
| Beschreibung: | Background Several patients with language-eloquent gliomas face language deterioration postoperatively. Persistent aphasia is frequently associated with damage to subcortical language pathways. Underlying mechanisms still need to be better understood, complicating preoperative risk assessment. This study compared qualitative and quantitative functionally relevant subcortical differences pre- and directly postoperatively in glioma patients with and without aphasia. Methods Language-relevant cortical sites were defined using navigated transcranial magnetic stimulation (nTMS) language mapping in 74 patients between 07/2016 and 07/2019. Post-hoc nTMS-based diffusion tensor imaging tractography was used to compare a tract’s pre- and postoperative visualization, volume and fractional anisotropy (FA), and the preoperative distance between tract and lesion and postoperative overlap with the resection cavity between the following groups: no aphasia (NoA), tumor- or previous resection induced aphasia persistent pre- and postoperatively (TIA_P), and surgery-induced transient or permanent aphasia (SIA_T or SIA_P). Results Patients with NoA, TIA_P, SIA_T, and SIA_P showed distinct fasciculus arcuatus (AF) and inferior-fronto-occipital fasciculus (IFOF) properties. The AF was more frequently reconstructable, and the FA of IFOF was higher in NoA than TIA_P cases (all p ≤ 0.03). Simultaneously, SIA_T cases showed higher IFOF fractional anisotropy than TIA_P cases (p Conclusion Functionally relevant qualitative and quantitative differences in AF and IFOF provide a pre- and postoperative pathophysiological and clinically relevant diagnostic indicator that supports surgical risk stratification. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1863-2661 |
| DOI: | 10.1007/s00429-024-02787-3 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/38597941 https://repository.publisso.de/resource/frl:6492451 https://mediatum.ub.tum.de/doc/1770786/document.pdf |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....bc21073f0976d021e86f9080e60ae1e8 |
| Datenbank: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Background Several patients with language-eloquent gliomas face language deterioration postoperatively. Persistent aphasia is frequently associated with damage to subcortical language pathways. Underlying mechanisms still need to be better understood, complicating preoperative risk assessment. This study compared qualitative and quantitative functionally relevant subcortical differences pre- and directly postoperatively in glioma patients with and without aphasia. Methods Language-relevant cortical sites were defined using navigated transcranial magnetic stimulation (nTMS) language mapping in 74 patients between 07/2016 and 07/2019. Post-hoc nTMS-based diffusion tensor imaging tractography was used to compare a tract’s pre- and postoperative visualization, volume and fractional anisotropy (FA), and the preoperative distance between tract and lesion and postoperative overlap with the resection cavity between the following groups: no aphasia (NoA), tumor- or previous resection induced aphasia persistent pre- and postoperatively (TIA_P), and surgery-induced transient or permanent aphasia (SIA_T or SIA_P). Results Patients with NoA, TIA_P, SIA_T, and SIA_P showed distinct fasciculus arcuatus (AF) and inferior-fronto-occipital fasciculus (IFOF) properties. The AF was more frequently reconstructable, and the FA of IFOF was higher in NoA than TIA_P cases (all p ≤ 0.03). Simultaneously, SIA_T cases showed higher IFOF fractional anisotropy than TIA_P cases (p Conclusion Functionally relevant qualitative and quantitative differences in AF and IFOF provide a pre- and postoperative pathophysiological and clinically relevant diagnostic indicator that supports surgical risk stratification. |
|---|---|
| ISSN: | 18632661 |
| DOI: | 10.1007/s00429-024-02787-3 |