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Antioxidant agents in wartime: prospects for the development of new biologically active compounds based on 1,2,4-triazole derivatives

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Název: Antioxidant agents in wartime: prospects for the development of new biologically active compounds based on 1,2,4-triazole derivatives
Autoři: K. K. Isaycheva, A. G. Kaplaushenko, Yu. G. Sameliuk, O. P. Shmatenko, A. M. Solomennyi
Zdroj: Український журнал військової медицини, Vol 6, Iss 2 (2025)
Informace o vydavateli: Ukrainian Military Medical Academy, 2025.
Rok vydání: 2025
Témata: Medicine, heterocyclic molecules, 1,2,4-triazole, biological activity, antioxidant activity
Popis: Introduction. This article presents an analysis of the antioxidant activity of 4-amino-5-(2-, 3-, 4-nitrophenyl)-1H-1,2,4-triazole-3-thiones and their synthetic analogues, 5-(4-methoxyphenyl, 3,4,5-trimethoxyphenyl)-1,2,4-triazole-3-thiones and their synthetic analogues, and 5-(quinolin-2-yl, 2-hydroxyquinolin-4-yl)-4-R1-1,2,4-triazole-3-thiones. The main conclusions drawn from these studies are as follows: The purpose: to evaluate the antioxidant activity of 1,2,4-triazole derivatives, specifically 4-amino-5-(2-, 3-, 4-nitrophenyl)-1H-1,2,4-triazole-3-thiones, 5-(4-methoxyphenyl-, 3,4,5-trimethoxyphenyl)-1,2,4-triazole-3-thiones, and 5-(quinolin-2-yl-, 2-hydroxyquinolin-4-yl)-4-R₁-1,2,4-triazole-3-thiones, in order to identify promising compounds with pronounced antioxidant activity for potential use in the correction of pathological conditions associated with oxidative stress, particularly among the military personnel of the Armed Forces of Ukraine. Materials and Methods: The study involved the synthesis and structural analysis of 1,2,4-triazole derivatives. The antioxidant activity was assessed using spectrophotometric and electrochemical methods, determining the ability of the studied compounds to neutralize free radicals and inhibit oxidative processes. The influence of chemical structure, particularly the nature of substituents at positions 4 and 5 of the triazole ring, on antioxidant properties was analyzed through a comparative study of the obtained results. Results. Derivatives of 5-R-3-thio-1,2,4-triazole show promise as potential matrices for the development of highly effective antioxidant agents. The antioxidant properties of these derivatives depend on the nature of the substituents at the 4 and 5 positions of the 1,2,4-triazole ring. The presence of a free SH group and its substituted products, such as thioacetic acids, their salts, and esters, also contribute to the antioxidant effect. Compounds with a greater number of electron-donating groups exhibit the highest antioxidant activity, highlighting the importance of these groups in providing effective protection against oxidative processes. Conclusions. The results of the conducted study confirm the potential of 1,2,4-triazole derivatives as compounds with antioxidant activity and provide an important scientific basis for further structural optimization to enhance their effectiveness. The obtained data contribute to the development of novel highly active antioxidant agents for the correction of pathological conditions associated with oxidative stress, particularly among the military personnel of the Armed Forces of Ukraine.
Druh dokumentu: Article
ISSN: 2708-6623
2708-6615
DOI: 10.46847/ujmm.2025.2(6)-125
Přístupová URL adresa: https://doaj.org/article/1bd9589e6071463eb535e1262e09de52
Rights: CC BY
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  Data: Antioxidant agents in wartime: prospects for the development of new biologically active compounds based on 1,2,4-triazole derivatives
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  Data: <searchLink fieldCode="AR" term="%22K%2E+K%2E+Isaycheva%22">K. K. Isaycheva</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+G%2E+Kaplaushenko%22">A. G. Kaplaushenko</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2E+G%2E+Sameliuk%22">Yu. G. Sameliuk</searchLink><br /><searchLink fieldCode="AR" term="%22O%2E+P%2E+Shmatenko%22">O. P. Shmatenko</searchLink><br /><searchLink fieldCode="AR" term="%22A%2E+M%2E+Solomennyi%22">A. M. Solomennyi</searchLink>
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  Data: Український журнал військової медицини, Vol 6, Iss 2 (2025)
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  Data: Ukrainian Military Medical Academy, 2025.
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  Label: Publication Year
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22heterocyclic+molecules%2C+1%2C2%2C4-triazole%2C+biological+activity%2C+antioxidant+activity%22">heterocyclic molecules, 1,2,4-triazole, biological activity, antioxidant activity</searchLink>
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  Label: Description
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  Data: Introduction. This article presents an analysis of the antioxidant activity of 4-amino-5-(2-, 3-, 4-nitrophenyl)-1H-1,2,4-triazole-3-thiones and their synthetic analogues, 5-(4-methoxyphenyl, 3,4,5-trimethoxyphenyl)-1,2,4-triazole-3-thiones and their synthetic analogues, and 5-(quinolin-2-yl, 2-hydroxyquinolin-4-yl)-4-R1-1,2,4-triazole-3-thiones. The main conclusions drawn from these studies are as follows: The purpose: to evaluate the antioxidant activity of 1,2,4-triazole derivatives, specifically 4-amino-5-(2-, 3-, 4-nitrophenyl)-1H-1,2,4-triazole-3-thiones, 5-(4-methoxyphenyl-, 3,4,5-trimethoxyphenyl)-1,2,4-triazole-3-thiones, and 5-(quinolin-2-yl-, 2-hydroxyquinolin-4-yl)-4-R₁-1,2,4-triazole-3-thiones, in order to identify promising compounds with pronounced antioxidant activity for potential use in the correction of pathological conditions associated with oxidative stress, particularly among the military personnel of the Armed Forces of Ukraine. Materials and Methods: The study involved the synthesis and structural analysis of 1,2,4-triazole derivatives. The antioxidant activity was assessed using spectrophotometric and electrochemical methods, determining the ability of the studied compounds to neutralize free radicals and inhibit oxidative processes. The influence of chemical structure, particularly the nature of substituents at positions 4 and 5 of the triazole ring, on antioxidant properties was analyzed through a comparative study of the obtained results. Results. Derivatives of 5-R-3-thio-1,2,4-triazole show promise as potential matrices for the development of highly effective antioxidant agents. The antioxidant properties of these derivatives depend on the nature of the substituents at the 4 and 5 positions of the 1,2,4-triazole ring. The presence of a free SH group and its substituted products, such as thioacetic acids, their salts, and esters, also contribute to the antioxidant effect. Compounds with a greater number of electron-donating groups exhibit the highest antioxidant activity, highlighting the importance of these groups in providing effective protection against oxidative processes. Conclusions. The results of the conducted study confirm the potential of 1,2,4-triazole derivatives as compounds with antioxidant activity and provide an important scientific basis for further structural optimization to enhance their effectiveness. The obtained data contribute to the development of novel highly active antioxidant agents for the correction of pathological conditions associated with oxidative stress, particularly among the military personnel of the Armed Forces of Ukraine.
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