Single nucleotide polymorphisms of 8 inflammation‐related genes and their associations with smoking‐related cancers
Uloženo v:
| Název: | Single nucleotide polymorphisms of 8 inflammation‐related genes and their associations with smoking‐related cancers |
|---|---|
| Autoři: | Oh, Sam S, Chang, Shen-Chih, Cai, Lin, Cordon-Cardo, Carlos, Ding, Bao-Guo, Greenland, Sander, He, Na, Jiang, Qingwu, Kheifets, Leeka, Le, Anh, Lee, Yuan-Chin Amy, Liu, Simin, Lu, Ming-Lan, Mao, Jenny T, Morgenstern, Hal, Mu, Li-Na, Pantuck, Allan, Papp, Jeanette C, Park, Sungshim Lani, Rao, Jian Yu, Reuter, Victor E, Tashkin, Donald P, Wang, Hua, You, Nai-Cheih Y, Yu, Shun-Zhang, Zhao, Jin-Kou, Belldegrun, Arie, Zhang, Zuo-Feng |
| Přispěvatelé: | Department of Epidemiology, University of Michigan, Ann Arbor, MI, Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China, Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY, Taixing City Center for Disease Control and Prevention (CDC), Taixing City, Jiangsu, China, Department of Statistics, UCLA, Los Angeles, CA, Fudan University School of Public Health, Shanghai, China, School of Dentistry, University of Southern California, Los Angeles, CA, Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, Center for Metabolic Disease Prevention, UCLA, Los Angeles, CA, Departments of Pathology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, Pulmonary and Critical Care Section, New Mexico VA Healthcare System, Albuquerque, NM, Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, Department of Human Genetics, UCLA, Los Angeles, CA, Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, Jiangsu CDC, Nanjing, Jiangsu, China, Gates Foundation Beijing Office, Beijing, China, Tel.: 310-825-8418, Fax: 310-206-6039, Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71-225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095-1772, USA |
| Zdroj: | International Journal of Cancer. 127:2169-2182 |
| Informace o vydavateli: | Wiley, 2010. |
| Rok vydání: | 2010 |
| Témata: | Male, Cancer Research, interleukin 1beta, Lung Neoplasms, genetic association, TNF, Author keywords: IL10, single nucleotide polymorphisms, Life and Medical Sciences, 0302 clinical medicine, tumor necrosis factor EMTREE medical terms: adult, single nucleotide polymorphism, Neoplasms, Smoking EMTREE drug terms: gamma interferon, genetic variability, gender, Oncology and Pathology, Bayesian learning, education, Smoking, article, kidney cancer, Single Nucleotide, Middle Aged, cancer susceptibility, 3. Good health, Oropharyngeal Neoplasms, esophagus cancer, priority journal, bladder cancer, ethnicity, Female, carcinogenesis, Adult, China, Oncology and Hematology, Polymorphism, Single Nucleotide, liver cancer, 03 medical and health sciences, tobacco-related cancer MeSH: Adult, Health Sciences, Humans, controlled study, human, Polymorphism, Laryngeal Neoplasms, Inflammation, epigenetics, larynx cancer, oropharynx cancer, major clinical study, lung cancer, age, inflammation, Case-Control Studies, gamma interferon receptor 1, interleukin 10, neoplasm |
| Popis: | Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco‐related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation‐related genes with tobacco‐related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case‐control studies from: Los Angeles (population‐based; 611 lung and 553 upper aero‐digestive tract cancer cases and 1,040 controls), Taixing, China (population‐based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan‐Kettering Cancer Center (hospital‐based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50–0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3–5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41–0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking‐related cancer (CC vs. CT+TT aOR: 0.36, 95% CI: 0.17–0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking‐related cancers among never smokers. |
| Druh dokumentu: | Article |
| Popis souboru: | 479061 bytes; 3118 bytes; application/pdf; text/plain |
| Jazyk: | English |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.25214 |
| Přístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.25214 https://pubmed.ncbi.nlm.nih.gov/20112337 https://deepblue.lib.umich.edu/handle/2027.42/78055 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932751/ http://europepmc.org/articles/PMC2932751 https://www.cabdirect.org/cabdirect/abstract/20103328354 https://core.ac.uk/display/3139935 http://deepblue.lib.umich.edu/bitstream/2027.42/78055/1/25214_ftp.pdf |
| Rights: | Wiley Online Library User Agreement |
| Přístupové číslo: | edsair.doi.dedup.....b207d13b79ad3f6f80ecefe6ebb7910f |
| Databáze: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Tobacco smoke and its metabolites are carcinogens that increase tissue oxidative stress and induce target tissue inflammation. We hypothesized that genetic variation of inflammatory pathway genes plays a role in tobacco‐related carcinogenesis and is modified by tobacco smoking. We evaluated the association of 12 single nucleotide polymorphisms of 8 inflammation‐related genes with tobacco‐related cancers (lung, oropharynx, larynx, esophagus, stomach, liver, bladder, and kidney) using 3 case‐control studies from: Los Angeles (population‐based; 611 lung and 553 upper aero‐digestive tract cancer cases and 1,040 controls), Taixing, China (population‐based; 218 esophagus, 206 stomach, 204 liver cancer cases, and 415 controls), and Memorial Sloan‐Kettering Cancer Center (hospital‐based; 227 bladder cancer cases and 211 controls). After adjusting for age, education, ethnicity, gender, and tobacco smoking, IL10 rs1800871 was inversely associated with oropharyngeal cancer (CT+TT vs. CC adjusted odds ratio [aOR]: 0.69, 95% confidence interval [CI]: 0.50–0.95), and was positively associated with lung cancer among never smokers (TT vs. CT+CC aOR: 2.5, 95% CI: 1.3–5.1) and inversely with oropharyngeal cancer among ever smokers (CT+TT vs. CC aOR: 0.63, 95% CI: 0.41–0.95). Among all pooled never smokers (588 cases and 816 controls), TNF rs1799964 was inversely associated with smoking‐related cancer (CC vs. CT+TT aOR: 0.36, 95% CI: 0.17–0.77). Bayesian correction for multiple comparisons suggests that chance is unlikely to explain our findings (although epigenetic mechanisms may be in effect), which support our hypotheses, suggesting that IL10 rs1800871 is a susceptibility marker for oropharyngeal and lung cancers, and that TNF rs1799964 is associated with smoking‐related cancers among never smokers. |
|---|---|
| ISSN: | 10970215 00207136 |
| DOI: | 10.1002/ijc.25214 |