Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow
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| Titel: | Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow |
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| Autoren: | Musaeus, Christian Sandøe, Kjaer, Troels Wesenberg, Lindberg, Ulrich, Vestergaard, Mark B., Bo, Henrik, Larsson, Wiberg, Press, Daniel Zvi, Andersen, Birgitte Bo, Høgh, Peter, Kidmose, Preben, Hemmsen, Martin Christian, Rank, Mike Lind, Hasselbalch, Steen Gregers, Waldemar, Gunhild, Frederiksen, Kristian Steen |
| Quelle: | Alzheimers Res Ther Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024) Musaeus, C S, Kjaer, T W, Lindberg, U, Vestergaard, M B, Bo, H, Larsson, W, Press, D Z, Andersen, B B, Høgh, P, Kidmose, P, Hemmsen, M C, Rank, M L, Hasselbalch, S G, Waldemar, G & Frederiksen, K S 2024, ' Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow ', Alzheimer's Research and Therapy, vol. 16, no. 1, 80 . https://doi.org/10.1186/s13195-024-01432-9 Musaeus, C S, Kjaer, T W, Lindberg, U, Vestergaard, M B, Bo, H, Larsson, W, Press, D Z, Andersen, B B, Høgh, P, Kidmose, P, Hemmsen, M C, Rank, M L, Hasselbalch, S G, Waldemar, G & Frederiksen, K S 2024, 'Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow', Alzheimer's Research & Therapy, vol. 16, no. 1, 80. https://doi.org/10.1186/s13195-024-01432-9 |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | Epilepsy/diagnostic imaging, Epilepsy, Alzheimer Disease/complications, Research, Epileptiform discharges, Neurosciences. Biological psychiatry. Neuropsychiatry, Spike frequency, Hippocampus, Temporal Lobe, 03 medical and health sciences, 0302 clinical medicine, Hyperperfusion, Alzheimer Disease, Cerebrovascular Circulation, Humans, EEG, Neurology. Diseases of the nervous system, RC346-429, Hippocampus/diagnostic imaging, Alzheimer's disease, RC321-571 |
| Beschreibung: | Background In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discharges and a study using intracranial electrodes have shown that these are very frequent in the hippocampus. However, it is not known whether there is an association between hippocampal hyperexcitability and regional cerebral blood flow (rCBF). The objective of the study was to investigate the association between rCBF in hippocampus and epileptiform discharges as measured with ear-EEG in patients with Alzheimer’s disease. Our hypothesis was that increased spike frequency may be associated with increased rCBF in hippocampus. Methods A total of 24 patients with AD, and 15 HC were included in the analysis. Using linear regression, we investigated the association between rCBF as measured with arterial spin-labelling MRI (ASL-MRI) in the hippocampus and the number of spikes/sharp waves per 24 h as assessed by ear-EEG. Results No significant difference in hippocampal rCBF was found between AD and HC (p-value = 0.367). A significant linear association between spike frequency and normalized rCBF in the hippocampus was found for patients with AD (estimate: 0.109, t-value = 4.03, p-value Conclusions Increased spike frequency was accompanied by a hemodynamic response of increased blood flow in the hippocampus in patients with AD. This phenomenon has also been shown in patients with epilepsy and supports the hypothesis of hyperexcitability in patients with AD. The lack of a significant difference in hippocampal rCBF may be due to an increased frequency of epileptiform discharges in patients with AD. Trial registration The study is registered at clinicaltrials.gov (NCT04436341). |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1758-9193 |
| DOI: | 10.1186/s13195-024-01432-9 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/38610005 https://doaj.org/article/717fb5de537b4cd4a7d4693bec1aff98 https://curis.ku.dk/ws/files/389509878/s13195_024_01432_9.pdf |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Dokumentencode: | edsair.doi.dedup.....b1c74a7cfbc1804a95f3c7617a0e55a6 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discharges and a study using intracranial electrodes have shown that these are very frequent in the hippocampus. However, it is not known whether there is an association between hippocampal hyperexcitability and regional cerebral blood flow (rCBF). The objective of the study was to investigate the association between rCBF in hippocampus and epileptiform discharges as measured with ear-EEG in patients with Alzheimer’s disease. Our hypothesis was that increased spike frequency may be associated with increased rCBF in hippocampus. Methods A total of 24 patients with AD, and 15 HC were included in the analysis. Using linear regression, we investigated the association between rCBF as measured with arterial spin-labelling MRI (ASL-MRI) in the hippocampus and the number of spikes/sharp waves per 24 h as assessed by ear-EEG. Results No significant difference in hippocampal rCBF was found between AD and HC (p-value = 0.367). A significant linear association between spike frequency and normalized rCBF in the hippocampus was found for patients with AD (estimate: 0.109, t-value = 4.03, p-value Conclusions Increased spike frequency was accompanied by a hemodynamic response of increased blood flow in the hippocampus in patients with AD. This phenomenon has also been shown in patients with epilepsy and supports the hypothesis of hyperexcitability in patients with AD. The lack of a significant difference in hippocampal rCBF may be due to an increased frequency of epileptiform discharges in patients with AD. Trial registration The study is registered at clinicaltrials.gov (NCT04436341). |
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| ISSN: | 17589193 |
| DOI: | 10.1186/s13195-024-01432-9 |