A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis
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| Název: | A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis |
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| Autoři: | Stefan Borgwardt, Boris-Stephan Rauchmann, Nikolaos Koutsouleris, Rachel Upthegrove, Johanna Weiske, Paolo Brambilla, Anne Ruef, Lana Kambeitz-Ilankovic, Raimo K. R. Salokangas, Marco Paolini, Linda A. Antonucci, Stephen J. Wood, Shalaila S. Haas, Julian Wenzel, Joseph Kambeitz, Bruno Biagianti, Eva Meisenzahl |
| Přispěvatelé: | Haas, Shalaila S., Antonucci, Linda A., Wenzel, Julian, Ruef, Anne, Biagianti, Bruno, Paolini, Marco, Rauchmann, Boris-Stephan, Weiske, Johanna, Kambeitz, Joseph, Borgwardt, Stefan, Brambilla, Paolo, Meisenzahl, Eva, Salokangas, Raimo K. R., Upthegrove, Rachel, Wood, Stephen J., Koutsouleris, Nikolao, Kambeitz-Ilankovic, Lana |
| Zdroj: | Neuropsychopharmacology |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2020. |
| Rok vydání: | 2020 |
| Témata: | Neuronal Plasticity, Brain, ta3124, Article, 03 medical and health sciences, Cognition, 0302 clinical medicine, Psychotic Disorders, neuroscience, psychiatry, Humans, Cognition Disorders, 10. No inequality, n.a, Cognition Disorders [MeSH], Psychotic Disorders/diagnostic imaging [MeSH], Humans [MeSH], Predictive markers, Neuronal Plasticity [MeSH], Cognition [MeSH], Brain [MeSH], Psychosis, Psychotic Disorders/therapy [MeSH] |
| Popis: | Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%,P p |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/s41386-020-00877-4 |
| DOI: | 10.1038/s41386020008774 |
| Přístupová URL adresa: | https://www.nature.com/articles/s41386-020-00877-4.pdf https://pubmed.ncbi.nlm.nih.gov/33027802 http://juuli.fi/Record/0372874720 https://doi.org/10.1038/s41386020008774 https://minerva-access.unimelb.edu.au/handle/11343/274236 https://www.nature.com/articles/s41386-020-00877-4.pdf https://europepmc.org/article/PMC/PMC8027389 https://www.ncbi.nlm.nih.gov/pubmed/33027802 https://research.birmingham.ac.uk/portal/files/112195493/s41386_020_00877_4.pdf https://findanexpert.unimelb.edu.au/scholarlywork/1468678-a-multivariate-neuromonitoring-approach-to-neuroplasticity-based-computerized-cognitive-training-in-recent-onset-psychosis https://hdl.handle.net/10281/407901 https://doi.org/10.1038/s41386-020-00877-4 https://repository.publisso.de/resource/frl:6471090 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....a896cdcb3e9bc6d3fe86eebf7866ce1e |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%,P p |
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| ISSN: | 1740634X 0893133X |
| DOI: | 10.1038/s41386-020-00877-4 |