Chemical modification of hemoglobin in intact whole cells: Morphological studes by scanning electron microscope
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| Názov: | Chemical modification of hemoglobin in intact whole cells: Morphological studes by scanning electron microscope |
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| Autori: | Cheng, LYL, Tam, JWO |
| Zdroj: | International Journal of Biochemistry. 14:461-465 |
| Informácie o vydavateľovi: | Elsevier BV, 1982. |
| Rok vydania: | 1982 |
| Predmety: | 0301 basic medicine, Microscopy, Hemolysis - Drug Effects, 0303 health sciences, Erythrocytes, Hemoglobins, Abnormal, Sickle Cell - Blood, Hemoglobins, Abnormal - Metabolism, Anemia, Anemia, Sickle Cell, Electron, Hemolysis, Anemia, Sickle Cell - Blood, 3. Good health, Hemoglobins, 03 medical and health sciences, Erythrocytes - Drug Effects - Ultrastructure, Microscopy, Electron, Scanning, Humans, Abnormal - Metabolism, Scanning |
| Popis: | 1. Whole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. 2. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. 3. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. 4. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(82)90113-6 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/7106347 http://europepmc.org/abstract/MED/7106347 https://www.ncbi.nlm.nih.gov/pubmed/7106347 https://www.sciencedirect.com/science/article/abs/pii/0020711X82901136 https://hub.hku.hk/handle/10722/147304 http://hdl.handle.net/10722/147304 |
| Rights: | Elsevier TDM |
| Prístupové číslo: | edsair.doi.dedup.....a451f11f9a32d9836c9ca1138cfc249c |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | 1. Whole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. 2. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. 3. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. 4. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM. |
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| ISSN: | 0020711X |
| DOI: | 10.1016/0020-711x(82)90113-6 |