In EDS ansehen

Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project: results from seven large European cohorts within the ELAPSE project

Gespeichert in:
Bibliographische Detailangaben
Titel: Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project: results from seven large European cohorts within the ELAPSE project
Autoren: Stafoggia, Massimo, Oftedal, Bente Margaret, Chen, Jie, Rodopoulou, Sophia P., Renzi, Matteo, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Mehta, Amar Jayant, Vienneau, D. S., Andersen, Zorana, Bellander, Tom D., Brandt, Jørgen, Cesaroni, Giulia, de Hoogh, Kees, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Jöckel, Karl Heinz, Jørgensen, Jeanette, Katsouyanni, K., Ketzel, Matthias, Kristoffersen, Doris Tove, Lager, Anton Carl Jonas, Leander, Karin, Liu, Shuo, Ljungman, Petter L.S., Nagel, Gabriele, Pershagen, Göran, Peters, Annette Michael, Raaschou-Nielsen, Ole, Rizzuto, Debora, Schramm, Sara Helena, Schwarze, Per Everhard, Severi, Gianluca, Sigsgaard, Torben, Strak, Maciej, van Der Schouw, Yvonne T., Verschuren, Monique M.W., Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Samoli, E., Forastiere, Francesco, Brunekreef, Bert, Hoek, Gerard, Janssen, Nicole A.H.
Weitere Verfasser: Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Public Health Practice, Faculty of Economic and Social Sciences and Solvay Business School, Sociology, Open Repository DS7.6 Demo, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Firenze = University of Florence = Université de Florence (UniFI), U.S. Environmental Protection Agency, EPA: R-82811201, Health Effects Institute, HEI: 4954-RFA14-3/16-5, All members of the ELAPSE collaborative group contributed to critical revision of the Article for important intellectual content. We acknowledge the services of Statistics Norway, the Norwegian Cause of Death Registry, and Cohort Norway (CONOR), the contributing research centres delivering data to CONOR, and all the study participants. All cohorts from CONOR were used in the analyses. The research leading to these results has received funding from the Health Effects Institute under grant 4954-RFA14-3/16-5. The research described in this Article was conducted under contract to the Health Effects Institute, an organisation jointly funded by the US Environmental Protection Agency (assistance award number R-82811201) and several motor vehicle and engine manufacturers and other sponsors. The contents of this Article do not necessarily reflect the views of the Health Effects Institute or its sponsors, nor do they necessarily reflect the views and policies of the US Environmental Protection Agency or motor vehicle and engine manufacturers., All members of the ELAPSE collaborative group contributed to critical revision of the Article for important intellectual content. We acknowledge the services of Statistics Norway, the Norwegian Cause of Death Registry, and Cohort Norway (CONOR), the contributing research centres delivering data to CONOR, and all the study participants. All cohorts from CONOR were used in the analyses. The research leading to these results has received funding from the Health Effects Institute under grant 4954-RFA14-3/16-5. The research described in this Article was conducted under contract to the Health Effects Institute, an organisation jointly funded by the US Environmental Protection Agency (assistance award number R-82811201) and several motor vehicle and engine manufacturers and other sponsors . The contents of this Article do not necessarily reflect the views of the Health Effects Institute or its sponsors, nor do they necessarily reflect the views and policies of the US Environmental Protection Agency or motor vehicle and engine manufacturers.
Quelle: The Lancet Planetary Health, Vol 6, Iss 1, Pp e9-e18 (2022)
e18
e9
Stafoggia, M, Oftedal, B, Chen, J, Rodopoulou, S, Renzi, M, Atkinson, R W, Bauwelinck, M, Klompmaker, J O, Mehta, A, Vienneau, D, Andersen, Z J, Bellander, T, Brandt, J, Cesaroni, G, de Hoogh, K, Fecht, D, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, U A, Jöckel, K H, Jørgensen, J T, Katsouyanni, K, Ketzel, M, Kristoffersen, D T, Lager, A, Leander, K, Liu, S, Ljungman, P L S, Nagel, G, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Rizzuto, D, Schramm, S, Schwarze, P E, Severi, G, Sigsgaard, T, Strak, M, van der Schouw, Y T, Verschuren, M, Weinmayr, G, Wolf, K, Zitt, E, Samoli, E, Forastiere, F, Brunekreef, B, Hoek, G & Janssen, N A H 2022, ' Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people : results from seven large European cohorts within the ELAPSE project ', The Lancet Planetary Health, vol. 6, no. 1, pp. e9-e18 . https://doi.org/10.1016/S2542-5196(21)00277-1
Lancet Planet Health 6, e9-e18 (2022)
Stafoggia, M, Oftedal, B, Chen, J, Rodopoulou, S, Renzi, M, Atkinson, R W, Bauwelinck, M, Klompmaker, J O, Mehta, A, Vienneau, D, Andersen, Z J, Bellander, T, Brandt, J, Cesaroni, G, de Hoogh, K, Fecht, D, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, U A, Jöckel, K-H, Jørgensen, J T, Katsouyanni, K, Ketzel, M, Kristoffersen, D T, Lager, A, Leander, K, Liu, S, Ljungman, P L S, Nagel, G, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Rizzuto, D, Schramm, S, Schwarze, P E, Severi, G, Sigsgaard, T, Strak, M, van der Schouw, Y T, Verschuren, M, Weinmayr, G, Wolf, K, Zitt, E, Samoli, E, Forastiere, F, Brunekreef, B, Hoek, G & Janssen, N A H 2022, 'Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people : results from seven large European cohorts within the ELAPSE project', The Lancet Planetary Health, vol. 6, no. 1, pp. e9-e18. https://doi.org/10.1016/S2542-5196(21)00277-1
Verlagsinformationen: Elsevier BV, 2022.
Publikationsjahr: 2022
Schlagwörter: Adult, Medizin, 01 natural sciences, Europe/epidemiology, 03 medical and health sciences, 0302 clinical medicine, environment/Health, Particulate Matter/adverse effects, Air Pollution, 11. Sustainability, Journal Article, Humans, Multicenter Studies as Topic, GE1-350, Longitudinal Studies, 0105 earth and related environmental sciences, Mortality, Premature, Research Support, Non-U.S. Gov't, Environmental Exposure, Air Pollution/adverse effects, 16. Peace & justice, 3. Good health, Environmental sciences, Europe, 13. Climate action, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Particulate Matter, Environmental Exposure/adverse effects, Meta-Analysis
Beschreibung: Long-term exposure to ambient air pollution has been associated with premature mortality, but associations at concentrations lower than current annual limit values are uncertain. We analysed associations between low-level air pollution and mortality within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE).In this multicentre longitudinal study, we analysed seven population-based cohorts of adults (age ≥30 years) within ELAPSE, from Belgium, Denmark, England, the Netherlands, Norway, Rome (Italy), and Switzerland (enrolled in 2000-11; follow-up until 2011-17). Mortality registries were used to extract the underlying cause of death for deceased individuals. Annual average concentrations of fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and tropospheric warm-season ozone (O3) from Europe-wide land use regression models at 100 m spatial resolution were assigned to baseline residential addresses. We applied cohort-specific Cox proportional hazard models with adjustment for area-level and individual-level covariates to evaluate associations with non-accidental mortality, as the main outcome, and with cardiovascular, non-malignant respiratory, and lung cancer mortality. Subset analyses of participants living at low pollutant concentrations (as per predefined values) and natural splines were used to investigate the concentration-response function. Cohort-specific effect estimates were pooled in a random-effects meta-analysis.We analysed 28 153 138 participants contributing 257 859 621 person-years of observation, during which 3 593 741 deaths from non-accidental causes occurred. We found significant positive associations between non-accidental mortality and PM2·5, NO2, and black carbon, with a hazard ratio (HR) of 1·053 (95% CI 1·021-1·085) per 5 μg/m3 increment in PM2·5, 1·044 (1·019-1·069) per 10 μg/m3 NO2, and 1·039 (1·018-1·059) per 0·5 × 10-5/m black carbon. Associations with PM2·5, NO2, and black carbon were slightly weaker for cardiovascular mortality, similar for non-malignant respiratory mortality, and stronger for lung cancer mortality. Warm-season O3 was negatively associated with both non-accidental and cause-specific mortality. Associations were stronger at low concentrations: HRs for non-accidental mortality at concentrations lower than the WHO 2005 air quality guideline values for PM2·5 (10 μg/m3) and NO2 (40 μg/m3) were 1·078 (1·046-1·111) per 5 μg/m3 PM2·5 and 1·049 (1·024-1·075) per 10 μg/m3 NO2. Similarly, the association between black carbon and non-accidental mortality was highest at low concentrations, with a HR of 1·061 (1·032-1·092) for exposure lower than 1·5× 10-5/m, and 1·081 (0·966-1·210) for exposure lower than 1·0× 10-5/m.Long-term exposure to concentrations of PM2·5 and NO2 lower than current annual limit values was associated with non-accidental, cardiovascular, non-malignant respiratory, and lung cancer mortality in seven large European cohorts. Continuing research on the effects of low concentrations of air pollutants is expected to further inform the process of setting air quality standards in Europe and other global regions.Health Effects Institute.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 2542-5196
DOI: 10.1016/s2542-5196(21)00277-1
DOI: 10.5451/unibas-ep90837
Zugangs-URL: http://www.thelancet.com/article/S2542519621002771/pdf
https://pubmed.ncbi.nlm.nih.gov/34998464
https://openaccess.sgul.ac.uk/id/eprint/114059/1/1-s2.0-S2542519621002771-main.pdf
https://doaj.org/article/a7cdc1cc5dd6412b867b1b2b5f24b459
https://dspace.library.uu.nl/handle/1874/446065
http://hdl.handle.net/10044/1/93499
https://pergamos.lib.uoa.gr/uoa/dl/object/3059796
https://edoc.unibas.ch/90837/
https://curis.ku.dk/ws/files/291215223/Long_term_exposure.pdf
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63998
https://biblio.vub.ac.be/vubir/(25c3655b-98d0-4a97-b1cc-a5b3af2fb88c).html
https://hdl.handle.net/10029/625654
Rights: CC BY NC ND
Dokumentencode: edsair.doi.dedup.....9d13c5eb2a1d84b3560bc6b8f1e2e60f
Datenbank: OpenAIRE
Beschreibung
Abstract:Long-term exposure to ambient air pollution has been associated with premature mortality, but associations at concentrations lower than current annual limit values are uncertain. We analysed associations between low-level air pollution and mortality within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE).In this multicentre longitudinal study, we analysed seven population-based cohorts of adults (age ≥30 years) within ELAPSE, from Belgium, Denmark, England, the Netherlands, Norway, Rome (Italy), and Switzerland (enrolled in 2000-11; follow-up until 2011-17). Mortality registries were used to extract the underlying cause of death for deceased individuals. Annual average concentrations of fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and tropospheric warm-season ozone (O3) from Europe-wide land use regression models at 100 m spatial resolution were assigned to baseline residential addresses. We applied cohort-specific Cox proportional hazard models with adjustment for area-level and individual-level covariates to evaluate associations with non-accidental mortality, as the main outcome, and with cardiovascular, non-malignant respiratory, and lung cancer mortality. Subset analyses of participants living at low pollutant concentrations (as per predefined values) and natural splines were used to investigate the concentration-response function. Cohort-specific effect estimates were pooled in a random-effects meta-analysis.We analysed 28 153 138 participants contributing 257 859 621 person-years of observation, during which 3 593 741 deaths from non-accidental causes occurred. We found significant positive associations between non-accidental mortality and PM2·5, NO2, and black carbon, with a hazard ratio (HR) of 1·053 (95% CI 1·021-1·085) per 5 μg/m3 increment in PM2·5, 1·044 (1·019-1·069) per 10 μg/m3 NO2, and 1·039 (1·018-1·059) per 0·5 × 10-5/m black carbon. Associations with PM2·5, NO2, and black carbon were slightly weaker for cardiovascular mortality, similar for non-malignant respiratory mortality, and stronger for lung cancer mortality. Warm-season O3 was negatively associated with both non-accidental and cause-specific mortality. Associations were stronger at low concentrations: HRs for non-accidental mortality at concentrations lower than the WHO 2005 air quality guideline values for PM2·5 (10 μg/m3) and NO2 (40 μg/m3) were 1·078 (1·046-1·111) per 5 μg/m3 PM2·5 and 1·049 (1·024-1·075) per 10 μg/m3 NO2. Similarly, the association between black carbon and non-accidental mortality was highest at low concentrations, with a HR of 1·061 (1·032-1·092) for exposure lower than 1·5× 10-5/m, and 1·081 (0·966-1·210) for exposure lower than 1·0× 10-5/m.Long-term exposure to concentrations of PM2·5 and NO2 lower than current annual limit values was associated with non-accidental, cardiovascular, non-malignant respiratory, and lung cancer mortality in seven large European cohorts. Continuing research on the effects of low concentrations of air pollutants is expected to further inform the process of setting air quality standards in Europe and other global regions.Health Effects Institute.
ISSN:25425196
DOI:10.1016/s2542-5196(21)00277-1