Neurotrophin signalling in amygdala-dependent cued fear learning
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| Title: | Neurotrophin signalling in amygdala-dependent cued fear learning |
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| Authors: | Susanne Meis, Thomas Endres, Volkmar Lessmann |
| Source: | Cell Tissue Res |
| Publisher Information: | Springer Science and Business Media LLC, 2020. |
| Publication Year: | 2020 |
| Subject Terms: | ddc:610, Brain-Derived Neurotrophic Factor, Extinction, Review, Fear, Amygdala, GABA, 03 medical and health sciences, BDNF, 0302 clinical medicine, Neurotrophin 3, LTP, Neurotrophin 3/physiology [MeSH], Humans [MeSH], Animals [MeSH], Amygdala [MeSH], Learning/physiology [MeSH], Signal Transduction [MeSH], Brain-Derived Neurotrophic Factor/genetics [MeSH], Fear/physiology [MeSH], Animals, Humans, Learning, Signal Transduction |
| Description: | The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1432-0878 0302-766X |
| DOI: | 10.1007/s00441-020-03260-3 |
| DOI: | 10.25673/64065 |
| Access URL: | https://link.springer.com/content/pdf/10.1007/s00441-020-03260-3.pdf https://pubmed.ncbi.nlm.nih.gov/32845430 https://link.springer.com/content/pdf/10.1007/s00441-020-03260-3.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529623 https://pubmed.ncbi.nlm.nih.gov/32845430/ https://link.springer.com/article/10.1007/s00441-020-03260-3 https://repository.publisso.de/resource/frl:6469460 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....8fc9dd5d15835fef8f05fa89369fa94d |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced. |
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| ISSN: | 14320878 0302766X |
| DOI: | 10.1007/s00441-020-03260-3 |