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Current and Novel Inhibitors of HIV Protease

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Bibliographic Details
Title: Current and Novel Inhibitors of HIV Protease
Authors: Ladislav Machala, Pavlína Řezáčová, Jana Pokorná, Jan Konvalinka
Source: Viruses
Viruses, Vol 1, Iss 3, Pp 1209-1239 (2009)
Publisher Information: MDPI AG, 2009.
Publication Year: 2009
Subject Terms: 0301 basic medicine, 0303 health sciences, HAART, pharmacokinetic boosting, protease inhibitors, Review, alternative inhibitors, Microbiology, QR1-502, 3. Good health, protease dimerization, 03 medical and health sciences, HIV protease, resistance development
Description: The design, development and clinical success of HIV protease inhibitors represent one of the most remarkable achievements of molecular medicine. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
Document Type: Article
Other literature type
Language: English
ISSN: 1999-4915
DOI: 10.3390/v1031209
Access URL: https://pubmed.ncbi.nlm.nih.gov/21994591
https://doaj.org/article/70031e2c4d9a450186517972e0a002e9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185513/figure/f5-viruses-01-01209/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185513
https://www.mdpi.com/1999-4915/1/3/1209/htm
http://europepmc.org/articles/PMC3185513
https://www.mysciencework.com/publication/show/current-and-novel-inhibitors-of-hiv-protease
https://www.mendeley.com/catalogue/9499cf85-4e59-309a-b5e7-dc427f275337/
Rights: CC BY
Accession Number: edsair.doi.dedup.....8c5fb1fa95035b9b9aa9b68ac3fe5ea9
Database: OpenAIRE
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