Cost-effectiveness of monitoring ocular hypertension based on a risk prediction tool
Uložené v:
| Názov: | Cost-effectiveness of monitoring ocular hypertension based on a risk prediction tool |
|---|---|
| Autori: | Hangjian Wu, Gus Gazzard, Anthony King, James Morgan, David Wright, David P Crabb, Yemisi Takwoingi, Augusto Azuara-Blanco, Verity Watson, Rodolfo Hernández |
| Prispievatelia: | University of Aberdeen.Health Economics Research Unit |
| Zdroj: | BMJ Open Ophthalmol BMJ Open Ophthalmology, Vol 9, Iss 1 (2024) Wu, H, Gazzard, G, King, A, Morgan, J, Wright, D, Crabb, D P, Takwoingi, Y, Azuara-Blanco, A, Watson, V & Hernández, R 2024, 'Cost-effectiveness of monitoring ocular hypertension based on a risk prediction tool', BMJ Open Ophthalmology, vol. 9, no. 1, e001741. https://doi.org/10.1136/bmjophth-2024-001741 |
| Informácie o vydavateľovi: | BMJ, 2024. |
| Rok vydania: | 2024 |
| Predmety: | Male, Ocular Hypertension/economics, Cost-Benefit Analysis, Risk Assessment, risk prediction, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Intraocular Pressure/physiology, Intraocular Pressure, Antihypertensive Agents, Aged, Antihypertensive Agents/therapeutic use, United Kingdom/epidemiology, Health Care Costs/statistics & numerical data, Glaucoma, Health Care Costs, RE1-994, Middle Aged, United Kingdom, 3. Good health, Ophthalmology, Ocular Hypertension, Female, Quality-Adjusted Life Years, 0305 other medical science |
| Popis: | Background/Aims To assess the cost-effectiveness of making treatment decisions for patients with ocular hypertension (OHT) based on a risk prediction (RP) tool in the United Kingdom. Methods A discrete event simulation model was constructed to compare the cost-effectiveness of an alternative care pathway in which the treatment decision was guided by a validated RP tool in secondary care against decision-making based on the standard care (SC). Individual patient sampling was used. Patients diagnosed with OHT and with an intraocular pressure of 24 mm Hg or over entered the model with a set of predefined individual characteristics related to their risk of conversion to glaucoma. These characteristics were retrieved from electronic medical records (n=5740). Different stages of glaucoma were modelled following conversion to glaucoma. Results Almost all (99%) patients were treated using the RP strategy, and less than half (47%) of the patients were treated using the SC strategy. The RP strategy produced higher cost but also higher quality-adjusted life years (QALYs) than the SC strategy. The RP strategy was cost-effective compared with the SC strategy in the base-case analysis, with an incremental cost-effectiveness ratio value of £11 522. The RP strategy had a 96% probability of being cost-effective under a £20 000 per QALY threshold. Conclusions The use of an RP tool for the management of patients with OHT is likely to be cost-effective. However, the generalisability of the result might be limited due to the high-risk nature of this cohort and the specific RP threshold used in the study. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2397-3269 |
| DOI: | 10.1136/bmjophth-2024-001741 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39209325 https://doaj.org/article/6f2afe0bbb7e4e9eb643b4eeaddc7230 https://pure.qub.ac.uk/en/publications/970df07d-15fc-4f2a-afc0-6153917f0bc4 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: http://creativecommons.org/licenses/by/4.0/. |
| Prístupové číslo: | edsair.doi.dedup.....841d238f801d3ac24e3736bae3f5a47e |
| Databáza: | OpenAIRE |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Background/Aims To assess the cost-effectiveness of making treatment decisions for patients with ocular hypertension (OHT) based on a risk prediction (RP) tool in the United Kingdom. Methods A discrete event simulation model was constructed to compare the cost-effectiveness of an alternative care pathway in which the treatment decision was guided by a validated RP tool in secondary care against decision-making based on the standard care (SC). Individual patient sampling was used. Patients diagnosed with OHT and with an intraocular pressure of 24 mm Hg or over entered the model with a set of predefined individual characteristics related to their risk of conversion to glaucoma. These characteristics were retrieved from electronic medical records (n=5740). Different stages of glaucoma were modelled following conversion to glaucoma. Results Almost all (99%) patients were treated using the RP strategy, and less than half (47%) of the patients were treated using the SC strategy. The RP strategy produced higher cost but also higher quality-adjusted life years (QALYs) than the SC strategy. The RP strategy was cost-effective compared with the SC strategy in the base-case analysis, with an incremental cost-effectiveness ratio value of £11 522. The RP strategy had a 96% probability of being cost-effective under a £20 000 per QALY threshold. Conclusions The use of an RP tool for the management of patients with OHT is likely to be cost-effective. However, the generalisability of the result might be limited due to the high-risk nature of this cohort and the specific RP threshold used in the study. |
|---|---|
| ISSN: | 23973269 |
| DOI: | 10.1136/bmjophth-2024-001741 |