View in EDS

The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

Saved in:
Bibliographic Details
Title: The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study
Authors: Paris Alexandros Lalousis, Oemer Faruk Oeztuerk, Peter Falkai, Katharine Chisholm, Nikolaos Koutsouleris, Stephan Ruhrmann, Paolo Brambilla, Linda A. Antonucci, Rachel Upthegrove, Shalaila S. Haas, Alessandro Pigoni, Raimo K. R. Salokangas, Julian Wenzel, Sian Lowri Griffiths, Dominic B. Dwyer, Theresa Lichtenstein, Christos Pantelis, Lana Kambeitz-Ilankovic, Frauke Schultze-Lutter, Stephen J. Wood, David Popovic, Marlene Rosen, Stefan Borgwardt, Peter F. Liddle, Anne Ruef, Eva Meisenzahl, Joseph Kambeitz
Contributors: Oeztuerk, Oemer Faruk, Pigoni, Alessandro, Wenzel, Julian, Haas, Shalaila S., Popovic, David, Ruef, Anne, Dwyer, Dominic B., Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Chisholm, Katharine, Lalousis, Pari, Griffiths, Sian Lowri, Lichtenstein, Theresa, Rosen, Marlene, Kambeitz, Joseph, Schultze-Lutter, Frauke, Liddle, Peter, Upthegrove, Rachel, Salokangas, Raimo K. R., Pantelis, Christo, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Falkai, Peter, Antonucci, Linda A., Koutsouleris, Nikolaos
Source: Eur Arch Psychiatry Clin Neurosci
Publisher Information: Springer Science and Business Media LLC, 2021.
Publication Year: 2021
Subject Terms: Original Paper, Formal thought disorder · Early psychosis · Clustering · Functioning · Neurocognition, Formal thought disorder, Early psychosis, Humans [MeSH], Semantics [MeSH], Functioning, Psychotic Disorders/complications [MeSH], Clustering, Neurocognition, Psychotic Disorders/psychology [MeSH], Psychotic Disorders/diagnosis [MeSH], Thinking/physiology [MeSH], Cognition [MeSH], Memory, Short-Term [MeSH], 1. No poverty, Semantics, 3. Good health, Thinking, 03 medical and health sciences, Cognition, Memory, Short-Term, 0302 clinical medicine, Psychotic Disorders, Humans
Description: BackgroundFormal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition.Methods279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS).ResultsThe results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (pfdr< 0.001) and role (pfdr < 0.001) functioning, as well as worse neurocognitive performance in semantic (pfdr< 0.001) and phonological verbal fluency (pfdr < 0.001), short-term verbal memory (pfdr = 0.002) and abstract thinking (pfdr = 0.010), in comparison to FTD-Low group.ConclusionsClustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1433-8491
0940-1334
DOI: 10.1007/s00406-021-01327-y
Access URL: https://link.springer.com/content/pdf/10.1007/s00406-021-01327-y.pdf
https://pubmed.ncbi.nlm.nih.gov/34535813
https://research.aston.ac.uk/en/publications/the-clinical-relevance-of-formal-thought-disorder-in-the-early-st
https://publications.aston.ac.uk/id/eprint/43168/
https://pubmed.ncbi.nlm.nih.gov/34535813/
https://link.springer.com/content/pdf/10.1007/s00406-021-01327-y.pdf
https://pure.mpg.de/pubman/faces/ViewItemOverviewPage.jsp?itemId=item_3345273
https://findanexpert.unimelb.edu.au/scholarlywork/1597218-the-clinical-relevance-of-formal-thought-disorder-in-the-early-stages-of-psychosis--results-from-the-pronia-study
https://hdl.handle.net/2434/869754
https://doi.org/10.1007/s00406-021-01327-y
https://repository.publisso.de/resource/frl:6447238
https://epub.ub.uni-muenchen.de/90850/
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Accession Number: edsair.doi.dedup.....7fcc6b718da295e94d30da55d19e477a
Database: OpenAIRE
Description
Abstract:BackgroundFormal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition.Methods279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS).ResultsThe results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (pfdr< 0.001) and role (pfdr < 0.001) functioning, as well as worse neurocognitive performance in semantic (pfdr< 0.001) and phonological verbal fluency (pfdr < 0.001), short-term verbal memory (pfdr = 0.002) and abstract thinking (pfdr = 0.010), in comparison to FTD-Low group.ConclusionsClustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.
ISSN:14338491
09401334
DOI:10.1007/s00406-021-01327-y