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Dyslipidemia in children with chronic kidney disease—findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study

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Title: Dyslipidemia in children with chronic kidney disease—findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study
Authors: Francesca Mencarelli, Karolis Azukaitis, Marietta Kirchner, Aysun Bayazit, Ali Duzova, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Bruno Ranchin, Rukshana Shroff, Salim Caliskan, Cengiz Candan, Alev Yilmaz, Zeynep Birsin Özcakar, Harika Halpay, Aysel Kiyak, Hakan Erdogan, Jutta Gellermann, Ayse Balat, Anette Melk, Franz Schaefer, Uwe Querfeld
Contributors: İstanbul University Cerrahpaşa Institutional Repository
Source: Pediatr Nephrol
Pediatric nephrology., New York : Springer, 2024, vol. 39, iss. 9, p. 2759-2772.
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Male, Adolescent, Comorbidity, Risk Factors, Chronic Kidney Disease, Albuminuria, Humans, Prospective Studies, Renal Insufficiency, Chronic, Child, Children, Triglycerides, Dyslipidemias, 2. Zero hunger, albuminuria, children, chronic kidney disease, dyslipidemia, fasting, Cardiovascular Diseases/etiology [MeSH], Risk Factors [MeSH], Renal Insufficiency, Chronic/complications [MeSH], Dyslipidemia, Dyslipidemias/blood [MeSH], Original Article, Lipids/blood [MeSH], Glomerular Filtration Rate [MeSH], Male [MeSH], Comorbidity [MeSH], Chronic kidney disease, Child [MeSH], Adolescent [MeSH], Female [MeSH], Humans [MeSH], Prospective Studies [MeSH], Proteinuria/epidemiology [MeSH], Renal Insufficiency, Chronic/blood [MeSH], Cardiovascular Diseases/epidemiology [MeSH], Cross-Sectional Studies [MeSH], Dyslipidemias/epidemiology [MeSH], Fasting, Renal Insufficiency, Chronic/epidemiology [MeSH], Triglycerides/blood [MeSH], What's New in Chronic Kidney Disease, Proteinuria/etiology [MeSH], Lipids, 3. Good health, Proteinuria, Cross-Sectional Studies, Cardiovascular Diseases, Female, Glomerular Filtration Rate
Description: Background Dyslipidemia is an important and modifiable risk factor for CVD in children with CKD. Methods In a cross-sectional study of baseline serum lipid levels in a large prospective cohort study of children with stage 3–5 (predialysis) CKD, frequencies of abnormal lipid levels and types of dyslipidemia were analyzed in the entire cohort and in subpopulations defined by fasting status or by the presence of nephrotic range proteinuria. Associated clinical and laboratory characteristics were determined by multivariable linear regression analysis. Results A total of 681 patients aged 12.2 ± 3.3 years with a mean eGFR of 26.9 ± 11.6 ml/min/1.73 m2 were included. Kidney diagnosis was classified as CAKUT in 69%, glomerulopathy in 8.4%, and other disorders in 22.6% of patients. Nephrotic range proteinuria (defined by a urinary albumin/creatinine ratio > 1.1 g/g) was present in 26.9%. Dyslipidemia was found in 71.8%, and high triglyceride (TG) levels were the most common abnormality (54.7%). Fasting status (38.9%) had no effect on dyslipidemia status. Except for a significant increase in TG in more advanced CKD, lipid levels and frequencies of dyslipidemia were not significantly different between CKD stages. Hypertriglyceridemia was associated with younger age, lower eGFR, shorter duration of CKD, higher body mass index (BMI-SDS), lower serum albumin, and higher diastolic blood pressure. Conclusions Dyslipidemia involving all lipid fractions, but mainly TG, is present in the majority of patients with CKD irrespective of CKD stage or fasting status and is significantly associated with other cardiovascular risk factors. Graphical abstract
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1432-198X
0931-041X
DOI: 10.1007/s00467-024-06389-3
Access URL: https://pubmed.ncbi.nlm.nih.gov/38720111
https://repository.publisso.de/resource/frl:6508600
https://repository.vu.lt/VU:ELABAPDB205643433&prefLang=en_US
https://avesis.uludag.edu.tr/publication/details/48d9ecd8-6489-47ae-b271-2d63a5a22dca/oai
Rights: CC BY
Accession Number: edsair.doi.dedup.....6b17f4920ff4fc96f781ca721d0a845c
Database: OpenAIRE
Description
Abstract:Background Dyslipidemia is an important and modifiable risk factor for CVD in children with CKD. Methods In a cross-sectional study of baseline serum lipid levels in a large prospective cohort study of children with stage 3–5 (predialysis) CKD, frequencies of abnormal lipid levels and types of dyslipidemia were analyzed in the entire cohort and in subpopulations defined by fasting status or by the presence of nephrotic range proteinuria. Associated clinical and laboratory characteristics were determined by multivariable linear regression analysis. Results A total of 681 patients aged 12.2 ± 3.3 years with a mean eGFR of 26.9 ± 11.6 ml/min/1.73 m2 were included. Kidney diagnosis was classified as CAKUT in 69%, glomerulopathy in 8.4%, and other disorders in 22.6% of patients. Nephrotic range proteinuria (defined by a urinary albumin/creatinine ratio > 1.1 g/g) was present in 26.9%. Dyslipidemia was found in 71.8%, and high triglyceride (TG) levels were the most common abnormality (54.7%). Fasting status (38.9%) had no effect on dyslipidemia status. Except for a significant increase in TG in more advanced CKD, lipid levels and frequencies of dyslipidemia were not significantly different between CKD stages. Hypertriglyceridemia was associated with younger age, lower eGFR, shorter duration of CKD, higher body mass index (BMI-SDS), lower serum albumin, and higher diastolic blood pressure. Conclusions Dyslipidemia involving all lipid fractions, but mainly TG, is present in the majority of patients with CKD irrespective of CKD stage or fasting status and is significantly associated with other cardiovascular risk factors. Graphical abstract
ISSN:1432198X
0931041X
DOI:10.1007/s00467-024-06389-3