A New AdvancedMRIBiomarker for Remyelinated Lesions in Multiple Sclerosis
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| Title: | A New AdvancedMRIBiomarker for Remyelinated Lesions in Multiple Sclerosis |
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| Authors: | Reza Rahmanzadeh, Riccardo Galbusera, Po‐Jui Lu, Erik Bahn, Matthias Weigel, Muhamed Barakovic, Jonas Franz, Thanh D. Nguyen, Pascal Spincemaille, Simona Schiavi, Alessandro Daducci, Francesco La Rosa, Martina Absinta, Pascal Sati, Meritxell Bach Cuadra, Ernst‐Wilhelm Radue, David Leppert, Jens Kuhle, Ludwig Kappos, Wolfgang Brück, Daniel S. Reich, Christine Stadelmann, Yi Wang, Cristina Granziera |
| Contributors: | Rahmanzadeh, Reza, Galbusera, Riccardo, Lu, Po‐Jui, Bahn, Erik, Weigel, Matthias, Barakovic, Muhamed, Franz, Jonas, Nguyen, Thanh D., Spincemaille, Pascal, Schiavi, Simona, Granziera, Cristina |
| Source: | Ann Neurol Annals of neurology, vol. 92, no. 3, pp. 486-502 |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Subject Terms: | 03 medical and health sciences, Cross-Sectional Studies, Multiple Sclerosis, 0302 clinical medicine, Brain, Humans, Water, Longitudinal Studies, Prospective Studies, Magnetic Resonance Imaging, Biomarkers, Brain/pathology, Magnetic Resonance Imaging/methods, Multiple Sclerosis/diagnostic imaging, Multiple Sclerosis/pathology, Research Articles |
| Description: | ObjectivesNeuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, in vivo in patients with MS.MethodsWe performed 3 studies: (1) a cross‐sectional study in a prospective cohort of 115 patients with MS and 76 healthy controls, who underwent 3 T magnetic resonance imaging (MRI) for quantitative susceptibility mapping (QSM), myelin water fraction (MWF), and neurite density index (NDI) maps. White matter (WM) lesions in QSM were classified into 5 QSM lesion types (iso‐intense, hypo‐intense, hyperintense, lesions with hypo‐intense rims, and lesions with paramagnetic rim legions [PRLs]); (2) a longitudinal study of 40 patients with MS to study the evolution of lesions over 2 years; (3) a postmortem histopathology‐QSM validation study in 3 brains of patients with MS to assess the accuracy of QSM classification to identify neuropathological lesion types in 63 WM lesions.ResultsAt baseline, hypo‐ and isointense lesions showed higher mean MWF and NDI values compared to other QSM lesion types (p InterpretationThese results provide the first evidence that it is possible to distinguish chronic MS lesions in a clinical setting, hereby supporting with new biomarkers to develop and assess remyelinating treatments. ANN NEUROL 2022;92:486–502 |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.26441 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/35713309 https://resolver.sub.uni-goettingen.de/purl?gro-2/112228 https://serval.unil.ch/notice/serval:BIB_A7E8C017F374 https://serval.unil.ch/resource/serval:BIB_A7E8C017F374.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_A7E8C017F3744 |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| Accession Number: | edsair.doi.dedup.....63f985c9f8d165d29d3c3a2e4067a87c |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | ObjectivesNeuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, in vivo in patients with MS.MethodsWe performed 3 studies: (1) a cross‐sectional study in a prospective cohort of 115 patients with MS and 76 healthy controls, who underwent 3 T magnetic resonance imaging (MRI) for quantitative susceptibility mapping (QSM), myelin water fraction (MWF), and neurite density index (NDI) maps. White matter (WM) lesions in QSM were classified into 5 QSM lesion types (iso‐intense, hypo‐intense, hyperintense, lesions with hypo‐intense rims, and lesions with paramagnetic rim legions [PRLs]); (2) a longitudinal study of 40 patients with MS to study the evolution of lesions over 2 years; (3) a postmortem histopathology‐QSM validation study in 3 brains of patients with MS to assess the accuracy of QSM classification to identify neuropathological lesion types in 63 WM lesions.ResultsAt baseline, hypo‐ and isointense lesions showed higher mean MWF and NDI values compared to other QSM lesion types (p InterpretationThese results provide the first evidence that it is possible to distinguish chronic MS lesions in a clinical setting, hereby supporting with new biomarkers to develop and assess remyelinating treatments. ANN NEUROL 2022;92:486–502 |
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| ISSN: | 15318249 03645134 |
| DOI: | 10.1002/ana.26441 |