Pupil size reveals arousal level fluctuations in human sleep
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| Title: | Pupil size reveals arousal level fluctuations in human sleep |
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| Authors: | Manuel Carro-Domínguez, Stephanie Huwiler, Stella Oberlin, Timona Leandra Oesch, Gabriela Badii, Anita Lüthi, Nicole Wenderoth, Sarah Nadine Meissner, Caroline Lustenberger |
| Source: | Nat Commun Nature Communications, Vol 16, Iss 1, Pp 1-14 (2025) Nature communications, vol. 16, no. 1, pp. 2070 Nature Communications, 16 (1) |
| Publisher Information: | Springer Science and Business Media LLC, 2025. |
| Publication Year: | 2025 |
| Subject Terms: | Male, Adult, Science, Polysomnography, Pupil, Electroencephalography, Article, Humans, Pupil/physiology, Arousal/physiology, Female, Sleep/physiology, Young Adult, Acoustic Stimulation, Arousal, Sleep |
| Description: | Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans, changes in arousal level are believed to be a determining characteristic of healthy and pathological sleep but tracking arousal level fluctuations has been methodologically challenging. Here we measured pupil size, an established indicator of arousal levels, by safely taping the right eye open during overnight sleep and tested whether pupil size affects cortical response to auditory stimulation. We show that pupil size dynamics change as a function of important sleep events across different temporal scales. In particular, our results show pupil size to be inversely related to the occurrence of sleep spindle clusters, a marker of sleep resilience. Additionally, we found pupil size prior to auditory stimulation to influence the evoked response, most notably in delta power, a marker of several restorative and regenerative functions of sleep. Recording pupil size dynamics provides insights into the interplay between arousal levels and sleep oscillations. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; application/application/pdf |
| Language: | English |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-57289-5 |
| DOI: | 10.3929/ethz-b-000726538 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/40021662 https://doaj.org/article/4cec5f6df7a34527a7f65596cd64f552 https://serval.unil.ch/notice/serval:BIB_BB615924CEA5 https://serval.unil.ch/resource/serval:BIB_BB615924CEA5.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_BB615924CEA53 http://hdl.handle.net/20.500.11850/726538 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....5feea1a40b9ee74e32f3cfe8f2f4efc7 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans, changes in arousal level are believed to be a determining characteristic of healthy and pathological sleep but tracking arousal level fluctuations has been methodologically challenging. Here we measured pupil size, an established indicator of arousal levels, by safely taping the right eye open during overnight sleep and tested whether pupil size affects cortical response to auditory stimulation. We show that pupil size dynamics change as a function of important sleep events across different temporal scales. In particular, our results show pupil size to be inversely related to the occurrence of sleep spindle clusters, a marker of sleep resilience. Additionally, we found pupil size prior to auditory stimulation to influence the evoked response, most notably in delta power, a marker of several restorative and regenerative functions of sleep. Recording pupil size dynamics provides insights into the interplay between arousal levels and sleep oscillations. |
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| ISSN: | 20411723 |
| DOI: | 10.1038/s41467-025-57289-5 |