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Urinary protein and coagulation‐fibrinolysis indicators in preeclampsia: Expression and significance

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Title: Urinary protein and coagulation‐fibrinolysis indicators in preeclampsia: Expression and significance
Authors: Zhen Chen, Fang Fang, Xiaoqian Yu
Source: J Clin Hypertens (Greenwich)
The Journal of Clinical Hypertension, Vol 26, Iss 4, Pp 374-381 (2024)
Publisher Information: Wiley, 2024.
Publication Year: 2024
Subject Terms: 0301 basic medicine, Fibrinolysis, Blood Pressure, Original Articles, Hypertension, Pregnancy-Induced, 3. Good health, preeclampsia, 03 medical and health sciences, thrombin time, urinary protein quantification, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, RC666-701, Diseases of the circulatory (Cardiovascular) system, Humans, Female, fibrinogen, urinary protein, Triglycerides
Description: This study investigates the expression and significance of urinary protein and coagulation‐fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally, 110 patients with gestational hypertension (gestational hypertension group) were included for comparative analysis. General information, laboratory indicators, urinary protein, and coagulation‐fibrinolysis indicator levels were collected for each group. Significant differences were observed in blood pressure among groups (P P > .05). Total cholesterol, triglycerides, and low‐density Lipoprotein levels in severe preeclampsia were higher than those in mild preeclampsia and gestational hypertension groups, whereas high‐density lipoprotein, albumin, and platelet levels were lower in severe preeclampsia. No significant differences were observed in prothrombin time or D‐dimer levels among groups (P > .05). Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse maternal and infant outcomes in severe preeclampsia patients. The study concludes that urinary protein and coagulation‐fibrinolysis indicators are elevated in preeclampsia, particularly in severe preeclampsia cases, suggesting their potential use as diagnostic influencing factors for severe preeclampsia.
Document Type: Article
Other literature type
Language: English
ISSN: 1751-7176
1524-6175
DOI: 10.1111/jch.14789
Access URL: https://pubmed.ncbi.nlm.nih.gov/38430460
https://doaj.org/article/718d8169c9c143f092fd96d96d140358
Rights: CC BY NC ND
URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Accession Number: edsair.doi.dedup.....5c114f7f4c30ab2f7279f30160cc1c7c
Database: OpenAIRE
Description
Abstract:This study investigates the expression and significance of urinary protein and coagulation‐fibrinolysis indicators in preeclampsia, categorized into mild preeclampsia (109 cases) and severe preeclampsia (97 cases) based on disease severity. Additionally, 110 patients with gestational hypertension (gestational hypertension group) were included for comparative analysis. General information, laboratory indicators, urinary protein, and coagulation‐fibrinolysis indicator levels were collected for each group. Significant differences were observed in blood pressure among groups (P P > .05). Total cholesterol, triglycerides, and low‐density Lipoprotein levels in severe preeclampsia were higher than those in mild preeclampsia and gestational hypertension groups, whereas high‐density lipoprotein, albumin, and platelet levels were lower in severe preeclampsia. No significant differences were observed in prothrombin time or D‐dimer levels among groups (P > .05). Urinary protein, urinary protein quantification, activated partial thromboplastin time, thrombin time, and fibrinogen were identified as influencing factors for adverse maternal and infant outcomes in severe preeclampsia patients. The study concludes that urinary protein and coagulation‐fibrinolysis indicators are elevated in preeclampsia, particularly in severe preeclampsia cases, suggesting their potential use as diagnostic influencing factors for severe preeclampsia.
ISSN:17517176
15246175
DOI:10.1111/jch.14789