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Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents

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Title: Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents
Authors: Sigri Kløve, Sara E. Stinson, Fie O. Romme, Julia Butt, Katrine B. Graversen, Morten A. V. Lund, Cilius E. Fonvig, Tim Waterboer, Guillermo I. Perez-Perez, Torben Hansen, Jens-Christian Holm, Sandra B. Andersen
Source: BMC Med
BMC Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Kløve, S, Stinson, S E, Romme, F O, Butt, J, Graversen, K B, Lund, M A V, Fonvig, C E, Waterboer, T, Perez-Perez, G I, Hansen, T, Holm, J-C & Andersen, S B 2024, ' Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents ', BMC Medicine, vol. 22, 379 . https://doi.org/10.1186/s12916-024-03591-w
Kløve, S, Stinson, S E, Romme, F O, Butt, J, Graversen, K B, Lund, M A V, Fonvig, C E, Waterboer, T, Perez-Perez, G I, Hansen, T, Holm, J-C & Andersen, S B 2024 ' Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity in Danish children and adolescents ' medRxiv . https://doi.org/10.1101/2024.02.09.24302062
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Male, Blood Glucose, Pediatric Obesity, Adolescent, Denmark, Adolescents, Helicobacter Infections, Body Mass Index, Cohort Studies, Young Adult, Seroepidemiologic Studies, Prevalence, Denmark/epidemiology [MeSH], Body mass index, Hyperglycemia/blood [MeSH], Pediatric Obesity/microbiology [MeSH], Helicobacter Infections/epidemiology [MeSH], Cohort Studies [MeSH], Hyperglycemia/epidemiology [MeSH], Male [MeSH], Hyperglycemia, Helicobacter pylori [MeSH], Prevalence [MeSH], Child [MeSH], Cardiometabolic risk factors, Pediatric Obesity/blood [MeSH], Obesity, Adolescent [MeSH], Female [MeSH], Pediatric Obesity/epidemiology [MeSH], Humans [MeSH], Blood Glucose/analysis [MeSH], Body Mass Index [MeSH], Seroepidemiologic Studies [MeSH], Helicobacter Infections/blood [MeSH], Children, Research, Young Adult [MeSH], Pediatric, Humans, Child, 2. Zero hunger, Helicobacter pylori, 3. Good health, Medicine, Female
Description: Background Helicobacter pylori colonizes the human stomach and may affect the inflammatory response, hormone production related to energy regulation, and gastrointestinal microbiota composition. Previous studies have explored a potential association between H. pylori infection and pediatric obesity with varying results. Considering the immunomodulatory effects of early-life infection with H. pylori that can confer beneficial effects, we hypothesized that we would find an inverse relationship between H. pylori seropositivity and obesity among Danish children and adolescents. Methods We assessed H. pylori seroprevalence in 713 subjects from an obesity clinic cohort and 990 subjects from a population-based cohort, aged 6 to 19 years, and examined its association with obesity and other cardiometabolic risk factors. Results No association was found between H. pylori and body mass index standard deviation score (BMI SDS). H. pylori seropositivity was, however, significantly associated with higher fasting plasma glucose levels and the prevalence of hyperglycemia. Conclusion While we did not find an association between H. pylori seropositivity and BMI SDS, we observed a significant association with higher fasting plasma glucose levels and increased prevalence of hyperglycemia, suggesting that H. pylori infection may contribute to impaired glucose regulation in Danish children and adolescents. Graphical abstract
Document Type: Article
Other literature type
Research
File Description: application/pdf
Language: English
ISSN: 1741-7015
DOI: 10.1186/s12916-024-03591-w
DOI: 10.1101/2024.02.09.24302062
Access URL: https://pubmed.ncbi.nlm.nih.gov/39256870
https://doaj.org/article/081ea9f67f8e48848d097370ea6c161d
https://curis.ku.dk/ws/files/405021423/Fulltext.pdf
https://curis.ku.dk/ws/files/452986996/Helicobacter_pyloriseropositivity.pdf
https://repository.publisso.de/resource/frl:6509762
Rights: CC BY
Accession Number: edsair.doi.dedup.....5b9e71b2bc3c0e3c15faaf8d7ade01bf
Database: OpenAIRE
Description
Abstract:Background Helicobacter pylori colonizes the human stomach and may affect the inflammatory response, hormone production related to energy regulation, and gastrointestinal microbiota composition. Previous studies have explored a potential association between H. pylori infection and pediatric obesity with varying results. Considering the immunomodulatory effects of early-life infection with H. pylori that can confer beneficial effects, we hypothesized that we would find an inverse relationship between H. pylori seropositivity and obesity among Danish children and adolescents. Methods We assessed H. pylori seroprevalence in 713 subjects from an obesity clinic cohort and 990 subjects from a population-based cohort, aged 6 to 19 years, and examined its association with obesity and other cardiometabolic risk factors. Results No association was found between H. pylori and body mass index standard deviation score (BMI SDS). H. pylori seropositivity was, however, significantly associated with higher fasting plasma glucose levels and the prevalence of hyperglycemia. Conclusion While we did not find an association between H. pylori seropositivity and BMI SDS, we observed a significant association with higher fasting plasma glucose levels and increased prevalence of hyperglycemia, suggesting that H. pylori infection may contribute to impaired glucose regulation in Danish children and adolescents. Graphical abstract
ISSN:17417015
DOI:10.1186/s12916-024-03591-w