Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation
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| Titel: | Brain network modulation in Alzheimer's and frontotemporal dementia with transcranial electrical stimulation |
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| Autoren: | Lorenzo Pini, Francesca Benedetta Pizzini, Ilaria Boscolo-Galazzo, Clarissa Ferrari, Samantha Galluzzi, Maria Cotelli, Elena Gobbi, Annamaria Cattaneo, Maria Sofia Cotelli, Cristina Geroldi, Orazio Zanetti, Maurizio Corbetta, Martijn van den Heuvel, Giovanni Battista Frisoni, Rosa Manenti, Michela Pievani |
| Quelle: | Neurobiology of Aging. 111:24-34 |
| Verlagsinformationen: | Elsevier BV, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Male, 0301 basic medicine, Frontotemporal Dementia / therapy, Nerve Net / pathology, Transcranial Direct Current Stimulation / methods, Alzheimer Disease / diagnosis, Frontotemporal Dementia / diagnosis, Brain / diagnostic imaging, Brain / physiopathology, Transcranial Direct Current Stimulation, Nerve Net / physiopathology, 618.97, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, Salience network, Humans, Network stimulation, Alzheimer Disease / physiopathology, Aged, Aged, 80 and over, Behavior, Brain / pathology, Brain, Alzheimer's disease, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Default mode network, Frontotemporal dementia, Frontotemporal Dementia, Frontotemporal Dementia / physiopathology, Alzheimer Disease / therapy, Female, Nerve Net |
| Beschreibung: | The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD. |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2021.11.005 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/34942516 https://research.vu.nl/en/publications/d04acfbe-0afd-4c11-a791-9de3a06c80a9 https://doi.org/10.1016/j.neurobiolaging.2021.11.005 https://hdl.handle.net/1871.1/d04acfbe-0afd-4c11-a791-9de3a06c80a9 https://www.sciencedirect.com/science/article/pii/S0197458021003341 https://archive-ouverte.unige.ch/unige:169331 https://doi.org/10.1016/j.neurobiolaging.2021.11.005 https://hdl.handle.net/11562/1055102 https://doi.org/10.1016/j.neurobiolaging.2021.11.005 https://hdl.handle.net/11577/3466059 https://doi.org/10.1016/j.neurobiolaging.2021.11.005 |
| Rights: | CC BY NC ND |
| Dokumentencode: | edsair.doi.dedup.....575f11e075daeb6f6e0b4115e4c8b22e |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal (target network: DMN in AD, SN in bvFTD) or cathodal stimulation (target network: SN in AD, DMN in bvFTD). We evaluated changes in clinical, cognitive, functional and structural connectivity, and perfusion measures. In both patient groups, cathodal stimulation was followed by behavioral improvement, whereas anodal stimulation led to cognitive improvement. Neither functional connectivity nor perfusion showed significant effects. A significant interaction between DMN and SN functional connectivity changes and stimulation protocol was reported in AD. These results suggest a protocol-dependent response, whereby the protocols studied show divergent effects on cognitive and clinical measures, along with a divergent modulatory pattern of connectivity in AD. |
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| ISSN: | 01974580 |
| DOI: | 10.1016/j.neurobiolaging.2021.11.005 |