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Phytochemical characterization and biological activities of Stenomesson miniatum bulb extract, a medicinal plant of the Andes

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Titel: Phytochemical characterization and biological activities of Stenomesson miniatum bulb extract, a medicinal plant of the Andes
Autoren: Mariacaterina Lianza, Carmela Fimognari, Jean-Marc Nuzillard, Ferruccio Poli, Jean-Hugues Renault, Francesca Bonvicini, Giulia Greco, Eleonora Turrini
Weitere Verfasser: Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)
Quelle: Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology. 158:182-189
Verlagsinformationen: Informa UK Limited, 2023.
Publikationsjahr: 2023
Schlagwörter: Artefact, Amaryllidaceae alkaloids, Urceolina peruviana, Stenomesson miniatum, Andean traditional medicine, 13 C-NMR-based dereplication, 15. Life on land, 3. Good health, Jurkat cells, [CHIM]Chemical Sciences, A431 human epidermoid carcinoma, amaryllidaceae alkaloids, urceolina peruviana, C-13-NMR-based dereplication, jurkat cells, artefact, andean traditional medicine
Beschreibung: The fresh bulbs of Stenomesson miniatum, a plant belonging to Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this study were to characterize the alkaloid extract from the bulbs of S. miniatum and test its cytotoxic and antibacterial potential. The alkaloid extract was characterized by dereplication using various techniques (CPC, NMR, UPLC-HRMS) and referring to in-home or online databases for spectroscopic data matching. Cytotoxic activities were evaluated on A431 human epidermoid carcinoma cells through a metabolic assay, and on Jurkat human acute T-leukemia cells through a cell-impermeant fluorescent nuclear probe. Antibacterial assays were carried out against Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes by using a standardized microdilution broth method 96-well plate. Eleven known Amaryllidaceae alkaloids were identified together with another compound determined as being an extraction artefact. The alkaloid extract showed good cytotoxic activity against both the tumor cell lines, reaching an IC50 of 3.3 µg/mL against A431 cells and of 10.9 µg/mL against Jurkat cells. The analysis of the fractions allowed the activity to be attributed to the presence of pretazettine and haemathamine. Conversely, no antibacterial activities were recorded for any of the samples.
Publikationsart: Article
Dateibeschreibung: application/pdf; application/zip
Sprache: English
ISSN: 1724-5575
1126-3504
DOI: 10.1080/11263504.2023.2293037
DOI: 10.20944/preprints202305.0921.v2
DOI: 10.5281/zenodo.4574016
Zugangs-URL: https://hdl.handle.net/11585/954209
https://doi.org/10.1080/11263504.2023.2293037
https://www.tandfonline.com/doi/full/10.1080/11263504.2023.2293037
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....5194e8e1a8830549a84fc82b51b42396
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  Data: Phytochemical characterization and biological activities of Stenomesson miniatum bulb extract, a medicinal plant of the Andes
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Mariacaterina+Lianza%22">Mariacaterina Lianza</searchLink><br /><searchLink fieldCode="AR" term="%22Carmela+Fimognari%22">Carmela Fimognari</searchLink><br /><searchLink fieldCode="AR" term="%22Jean-Marc+Nuzillard%22">Jean-Marc Nuzillard</searchLink><br /><searchLink fieldCode="AR" term="%22Ferruccio+Poli%22">Ferruccio Poli</searchLink><br /><searchLink fieldCode="AR" term="%22Jean-Hugues+Renault%22">Jean-Hugues Renault</searchLink><br /><searchLink fieldCode="AR" term="%22Francesca+Bonvicini%22">Francesca Bonvicini</searchLink><br /><searchLink fieldCode="AR" term="%22Giulia+Greco%22">Giulia Greco</searchLink><br /><searchLink fieldCode="AR" term="%22Eleonora+Turrini%22">Eleonora Turrini</searchLink>
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  Data: Alma Mater Studiorum Università di Bologna = University of Bologna (UNIBO)<br />Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR)<br />Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé)<br />Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet<br />Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)
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  Data: <i>Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology</i>. 158:182-189
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  Data: Informa UK Limited, 2023.
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  Data: 2023
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  Data: <searchLink fieldCode="DE" term="%22Artefact%22">Artefact</searchLink><br /><searchLink fieldCode="DE" term="%22Amaryllidaceae+alkaloids%22">Amaryllidaceae alkaloids</searchLink><br /><searchLink fieldCode="DE" term="%22Urceolina+peruviana%22">Urceolina peruviana</searchLink><br /><searchLink fieldCode="DE" term="%22Stenomesson+miniatum%22">Stenomesson miniatum</searchLink><br /><searchLink fieldCode="DE" term="%22Andean+traditional+medicine%22">Andean traditional medicine</searchLink><br /><searchLink fieldCode="DE" term="%2213+C-NMR-based+dereplication%22">13 C-NMR-based dereplication</searchLink><br /><searchLink fieldCode="DE" term="%2215%2E+Life+on+land%22">15. Life on land</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink><br /><searchLink fieldCode="DE" term="%22Jurkat+cells%22">Jurkat cells</searchLink><br /><searchLink fieldCode="DE" term="%22[CHIM]Chemical+Sciences%22">[CHIM]Chemical Sciences</searchLink><br /><searchLink fieldCode="DE" term="%22A431+human+epidermoid+carcinoma%22">A431 human epidermoid carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22amaryllidaceae+alkaloids%22">amaryllidaceae alkaloids</searchLink><br /><searchLink fieldCode="DE" term="%22urceolina+peruviana%22">urceolina peruviana</searchLink><br /><searchLink fieldCode="DE" term="%22C-13-NMR-based+dereplication%22">C-13-NMR-based dereplication</searchLink><br /><searchLink fieldCode="DE" term="%22jurkat+cells%22">jurkat cells</searchLink><br /><searchLink fieldCode="DE" term="%22artefact%22">artefact</searchLink><br /><searchLink fieldCode="DE" term="%22andean+traditional+medicine%22">andean traditional medicine</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The fresh bulbs of Stenomesson miniatum, a plant belonging to Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this study were to characterize the alkaloid extract from the bulbs of S. miniatum and test its cytotoxic and antibacterial potential. The alkaloid extract was characterized by dereplication using various techniques (CPC, NMR, UPLC-HRMS) and referring to in-home or online databases for spectroscopic data matching. Cytotoxic activities were evaluated on A431 human epidermoid carcinoma cells through a metabolic assay, and on Jurkat human acute T-leukemia cells through a cell-impermeant fluorescent nuclear probe. Antibacterial assays were carried out against Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes by using a standardized microdilution broth method 96-well plate. Eleven known Amaryllidaceae alkaloids were identified together with another compound determined as being an extraction artefact. The alkaloid extract showed good cytotoxic activity against both the tumor cell lines, reaching an IC50 of 3.3 µg/mL against A431 cells and of 10.9 µg/mL against Jurkat cells. The analysis of the fractions allowed the activity to be attributed to the presence of pretazettine and haemathamine. Conversely, no antibacterial activities were recorded for any of the samples.
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      – SubjectFull: Artefact
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      – SubjectFull: Amaryllidaceae alkaloids
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