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The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy

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Title: The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy
Authors: Raed AlRuwaili, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Naif H. Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Source: Neurochem Res
Publisher Information: Springer Science and Business Media LLC, 2023.
Publication Year: 2023
Subject Terms: Epilepsy, Seizures, Brain-Derived Neurotrophic Factor, Humans, Receptor, trkB, Seizures/metabolism [MeSH], mTOR pathway, Brain-derived neurotrophic factor, Epilepsy/metabolism [MeSH], Humans [MeSH], Brain-Derived Neurotrophic Factor/metabolism [MeSH], Seizure, Progranulin and α-synuclein, TrkB, Signal Transduction/physiology [MeSH], Review, Receptor, trkB/metabolism [MeSH], Hippocampus/metabolism [MeSH], Hippocampus, Signal Transduction, 3. Good health
Description: Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and α-Synuclein (α-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway. Therefore, the assessment of BDNF levels in epilepsy should be related to other neuronal signaling pathways and types of epilepsy in both preclinical and clinical studies. In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.
Document Type: Article
Other literature type
Language: English
ISSN: 1573-6903
0364-3190
DOI: 10.1007/s11064-023-04064-x
Access URL: https://pubmed.ncbi.nlm.nih.gov/38006577
https://repository.publisso.de/resource/frl:6496640
Rights: CC BY
Accession Number: edsair.doi.dedup.....504ca1ea1bda63e9b195aa7d8cfd6a08
Database: OpenAIRE
Description
Abstract:Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and α-Synuclein (α-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway. Therefore, the assessment of BDNF levels in epilepsy should be related to other neuronal signaling pathways and types of epilepsy in both preclinical and clinical studies. In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.
ISSN:15736903
03643190
DOI:10.1007/s11064-023-04064-x