Longitudinal associations of diet quality with serum biomarkers of lipid and amino acid metabolism from childhood to adolescence: the PANIC study
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| Title: | Longitudinal associations of diet quality with serum biomarkers of lipid and amino acid metabolism from childhood to adolescence: the PANIC study |
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| Authors: | Haapala Eero, Soininen Sonja Pauliina, Lakka Timo Antero, Schwab Ursula Sonja, Eloranta Aino-Maija, Heinonen Saara Maria, Laamanen Suvi Eveliina, Sallinen Taisa Maria |
| Source: | Br J Nutr |
| Publisher Information: | Cambridge University Press (CUP), 2025. |
| Publication Year: | 2025 |
| Subject Terms: | biomarkkerit, lapset (ikäryhmät), diet quality, pitkittäistutkimus, Liikuntalääketiede, ruokavaliot, rasva-aineenvaihdunta, nuoret, food consumption, sydän- ja verisuonitaudit, Biomekaniikka, Biomechanics, aineenvaihduntatuotteet, PANIC, Sports and Exercise Medicine, Research Article |
| Description: | Studies on longitudinal associations between diet quality and lipid and amino acid metabolism in children and adolescents are limited. We studied associations between diet quality and serum markers of lipid and amino acid metabolism in the Physical Activity and Nutrition in Children (PANIC) study. These analyses included 403 children aged 6–9 years at baseline, 360 re-examined 2 years later at age 9–11 years and 219 eight years later at age 15–17 years. Food intake was recorded over 4 days, and diet quality was assessed using the Finnish Children Healthy Eating Index (FCHEI). Fasting serum fatty acids, amino acids, apolipoproteins and lipoprotein particle sizes were analysed via NMR spectroscopy. Linear mixed-effects models, adjusted for sex, age, body fat percentage, pubertal stage and physical activity were used to analyse the associations. Better diet quality was linked to increased serum PUFA and reduced saturated and MUFA, alanine and VLDL particle size. Consuming more vegetables, fruits, berries, vegetable oils and margarine with at least 60 % fat, fish and whole grains is associated with higher serum PUFA, lower SFA and smaller VLDL particles. Conversely, consuming higher-fat dairy products and sugary products is associated with higher saturated and MUFA, branched-chain and aromatic amino acids and larger VLDL particles. A diet rich in fruits, vegetables, unsaturated fats and fibre, with reduced sugar consumption, promotes favourable metabolic changes relevant to cardiometabolic health. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; fulltext |
| Language: | English |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114525000492 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/40082079 http://urn.fi/URN:NBN:fi:jyu-202505134215 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
| Accession Number: | edsair.doi.dedup.....4a7527f9c6380c6de69dac69d6880f10 |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Studies on longitudinal associations between diet quality and lipid and amino acid metabolism in children and adolescents are limited. We studied associations between diet quality and serum markers of lipid and amino acid metabolism in the Physical Activity and Nutrition in Children (PANIC) study. These analyses included 403 children aged 6–9 years at baseline, 360 re-examined 2 years later at age 9–11 years and 219 eight years later at age 15–17 years. Food intake was recorded over 4 days, and diet quality was assessed using the Finnish Children Healthy Eating Index (FCHEI). Fasting serum fatty acids, amino acids, apolipoproteins and lipoprotein particle sizes were analysed via NMR spectroscopy. Linear mixed-effects models, adjusted for sex, age, body fat percentage, pubertal stage and physical activity were used to analyse the associations. Better diet quality was linked to increased serum PUFA and reduced saturated and MUFA, alanine and VLDL particle size. Consuming more vegetables, fruits, berries, vegetable oils and margarine with at least 60 % fat, fish and whole grains is associated with higher serum PUFA, lower SFA and smaller VLDL particles. Conversely, consuming higher-fat dairy products and sugary products is associated with higher saturated and MUFA, branched-chain and aromatic amino acids and larger VLDL particles. A diet rich in fruits, vegetables, unsaturated fats and fibre, with reduced sugar consumption, promotes favourable metabolic changes relevant to cardiometabolic health. |
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| ISSN: | 14752662 00071145 |
| DOI: | 10.1017/s0007114525000492 |