Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study
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| Titel: | Maternal serum glycosylated fibronectin as a short-term predictor of preeclampsia: a prospective cohort study |
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| Autoren: | Evelyn A. Huhn, Ina Hoffmann, Begoña Martinez De Tejada, Soeren Lange, Kylie M. Sage, Charles T. Roberts, Michael G. Gravett, Srinivasa R. Nagalla, Olav Lapaire |
| Quelle: | BMC Pregnancy Childbirth BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-8 (2020) BMC Pregnancy and Childbirth, Vol. 20, No 1 (2020) P. 128 |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2020. |
| Publikationsjahr: | 2020 |
| Schlagwörter: | Adult, Glycation End Products, Advanced, Gestational Age, Pregnancy Proteins, Sensitivity and Specificity, Cohort Studies, Vascular Endothelial Growth Factor Receptor-1 / blood, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Risk Factors, Biomarkers / blood, Humans, Prospective Studies, Placenta Growth Factor / blood, Placenta Growth Factor, Immunoassay, 2. Zero hunger, ddc:618, Vascular Endothelial Growth Factor Receptor-1, Gynecology and obstetrics, Fibronectins, 3. Good health, ROC Curve, Case-Control Studies, RG1-991, Fibronectins / blood, Female, Pre-Eclampsia / blood, Pregnancy Proteins / blood, Biomarkers, Research Article |
| Beschreibung: | Background Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous diagnosis of preeclampsia based on clinical parameters alone. Biomarkers that detect biochemical disease have been proposed as complements or alternatives to clinical criteria to improve diagnostic accuracy. This cohort study assessed the performance of several biomarkers, including glycosylated fibronectin (GlyFn), to rule-in or rule-out preeclampsia within 4 weeks in a cohort of women at increased risk for preeclampsia. Methods 151 women with risk factors for or clinical signs and symptoms of preeclampsia were selected from a prospective cohort. Maternal serum samples were collected between 20 and 37 weeks of gestation. Clinical suspicion of preeclampsia was defined as presence of new-onset proteinuria, or clinical symptoms of preeclampsia. Subjects with a clinical diagnosis of preeclampsia at the time of enrollment were excluded. GlyFn, pregnancy-associated plasma protein-A2 (PAPPA2), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured by immunoassay. GlyFn was also determined using a rapid point-of care (POC) test format. Receiver-operating characteristic (ROC) curves derived from logistic regression analysis were used to determine the classification performance for each analyte. Results 32 of 151 (21%) women developed a clinical diagnosis of preeclampsia within 4 weeks. All biomarkers exhibited good classification performance [GlyFn (area under the curve (AUROC) = 0.94, 91% sensitivity, 86% specificity); PAPPA2 AUC = 0.92, 87% sensitivity, 77% specificity; PlGF AUC = 0.90, 81% sensitivity, 83% specificity; sFlt-1 AUC = 0.92, 84% sensitivity, 91% specificity. The GlyFn immunoassay and the rapid POC test showed a correlation of r = 0.966. Conclusions In this prospective cohort, serum biomarkers of biochemical disease were effective in short-term prediction of preeclampsia, and the performance of GlyFn in particular as a POC test may meet the needs of rapid and accurate triage and intervention. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1471-2393 |
| DOI: | 10.1186/s12884-020-2809-2 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/32093623 https://doaj.org/article/8781ce9ec13047d78a79106a1a3cfe33 https://www.mendeley.com/catalogue/c1e72baa-92b3-38d4-bee2-4b2d321389fe/ https://europepmc.org/article/MED/32093623 https://ohsu.pure.elsevier.com/en/publications/maternal-serum-glycosylated-fibronectin-as-a-short-term-predictor https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-020-2809-2 https://link.springer.com/content/pdf/10.1186/s12884-020-2809-2.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041257/ https://archive-ouverte.unige.ch/unige:157749 https://doi.org/10.1186/s12884-020-2809-2 https://archive-ouverte.unige.ch/unige:157749 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....4a67da7e73e24e6d1a19a8b0ae3dc08e |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Background Preeclampsia is a major pregnancy complication that results in significant maternal and infant mortality, most of which occurs in low and middle-income countries. The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous diagnosis of preeclampsia based on clinical parameters alone. Biomarkers that detect biochemical disease have been proposed as complements or alternatives to clinical criteria to improve diagnostic accuracy. This cohort study assessed the performance of several biomarkers, including glycosylated fibronectin (GlyFn), to rule-in or rule-out preeclampsia within 4 weeks in a cohort of women at increased risk for preeclampsia. Methods 151 women with risk factors for or clinical signs and symptoms of preeclampsia were selected from a prospective cohort. Maternal serum samples were collected between 20 and 37 weeks of gestation. Clinical suspicion of preeclampsia was defined as presence of new-onset proteinuria, or clinical symptoms of preeclampsia. Subjects with a clinical diagnosis of preeclampsia at the time of enrollment were excluded. GlyFn, pregnancy-associated plasma protein-A2 (PAPPA2), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) were measured by immunoassay. GlyFn was also determined using a rapid point-of care (POC) test format. Receiver-operating characteristic (ROC) curves derived from logistic regression analysis were used to determine the classification performance for each analyte. Results 32 of 151 (21%) women developed a clinical diagnosis of preeclampsia within 4 weeks. All biomarkers exhibited good classification performance [GlyFn (area under the curve (AUROC) = 0.94, 91% sensitivity, 86% specificity); PAPPA2 AUC = 0.92, 87% sensitivity, 77% specificity; PlGF AUC = 0.90, 81% sensitivity, 83% specificity; sFlt-1 AUC = 0.92, 84% sensitivity, 91% specificity. The GlyFn immunoassay and the rapid POC test showed a correlation of r = 0.966. Conclusions In this prospective cohort, serum biomarkers of biochemical disease were effective in short-term prediction of preeclampsia, and the performance of GlyFn in particular as a POC test may meet the needs of rapid and accurate triage and intervention. |
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| ISSN: | 14712393 |
| DOI: | 10.1186/s12884-020-2809-2 |