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Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma

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Název: Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma
Autoři: Fu, Ling-ling, Yan, Ming, Yu, Xin, Shao, Min, Gosau, Martin, Friedrich, Reinhard E., Vollkommer, Tobias, Smeets, Ralf, Feng, Hong-chao, Xu, Liya
Zdroj: BMC Cancer
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, RBP1, Squamous Cell Carcinoma of Head and Neck, Research, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Head and neck squamous cell carcinoma, Retinol-Binding Proteins, Cellular, Prognosis biomarker, DNA Methylation, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Nomograms, Gene Expression Regulation, Neoplastic [MeSH], Aged [MeSH], Squamous Cell Carcinoma of Head and Neck/pathology [MeSH], Retinol-Binding Proteins, Cellular [MeSH], Head and Neck Neoplasms/genetics [MeSH], RNA, Messenger/genetics [MeSH], Male [MeSH], Squamous Cell Carcinoma of Head and Neck/mortality [MeSH], Retinol-Binding Proteins, Plasma/genetics [MeSH], RNA, Messenger/metabolism [MeSH], Female [MeSH], Squamous Cell Carcinoma of Head and Neck/metabolism [MeSH], Bioinformatic analysis, Humans [MeSH], Head and Neck Neoplasms/metabolism [MeSH], Retinol-Binding Proteins, Plasma/metabolism [MeSH], Middle Aged [MeSH], Head and Neck Neoplasms/mortality [MeSH], Squamous Cell Carcinoma of Head and Neck/genetics [MeSH], Nomograms [MeSH], Biomarkers, Tumor/metabolism [MeSH], DNA Methylation [MeSH], Biomarkers, Tumor/genetics [MeSH], Prognosis [MeSH], Head and Neck Neoplasms/pathology [MeSH], Head and Neck Neoplasms, Biomarkers, Tumor, Humans, Female, RNA, Messenger, Retinol-Binding Proteins, Plasma, RC254-282, Aged
Popis: Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database. Materials and methods RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA). Results The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P P Conclusion RBP1 is overexpressed and associated with poor patient prognosis in head and neck squamous cell carcinoma.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1471-2407
DOI: 10.1186/s12885-024-12565-3
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39407127
https://doaj.org/article/31bfdde01fcb44feb8485bed198b315c
https://repository.publisso.de/resource/frl:6512630
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Přístupové číslo: edsair.doi.dedup.....44976f7b43d05d742f5f6fc30b1c86e6
Databáze: OpenAIRE
Popis
Abstrakt:Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database. Materials and methods RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 6 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA). Results The mRNA expression levels of RBP1 were highly expressed in HNSCC tissue. The Cox analyses demonstrate that highly-expressed RBP1 is an independent prognosis marker(P P Conclusion RBP1 is overexpressed and associated with poor patient prognosis in head and neck squamous cell carcinoma.
ISSN:14712407
DOI:10.1186/s12885-024-12565-3